Search Results (12)

The enforcement of the European Union Deforestation Regulation (EUDR) may reduce the supply of natural rubber to the European Union (EU), potentially leading to price increases due to the inelastic nature of rubber demand. This study assesses the potential financial implications for smallholder producers in Ghana, considering both the opportunities and risks associated with the evolving regulatory environment under EUDR and local market access conditions. A cost–benefit analysis (CBA) was conducted to evaluate the impact of different EUDR-related export decline scenarios on the net present value (NPV) of a standard 4-hectare plantation. The results suggest that even a minor 2.5% decline in global exports to the EU could increase the NPV by 17% for an independent compliant producer. However, a simulated COVID-19-like crisis in the fifth year of production leads to a 20% decline in NPV, reflecting vulnerability to external shocks. Based on these findings, the study identifies two priorities. This first is improving the coordination and harmonization of compliance efforts across the value chain to enable more producers to benefit from potential EUDR-related price increases. The recent creation of the Association of Natural Rubber Actors of Ghana (ANRAG) presents an opportunity to support such collective mechanisms. Second, minimizing losses during demand shocks requires the Tree Crops Development Authority (TCDA) to establish clear rules and transparent reporting for authorizing unprocessed rubber exports when factories reduce purchases due to low international prices—thus preserving market access for vulnerable producers. Together, these approaches would ensure that the potential benefits of the EUDR are realized inclusively, remain stable despite market downturns, and do not undermine value addition in domestic processing factories. Full article

The recent advancements and emergence of rapidly evolving AI models, such as large language models (LLMs), have sparked interest among researchers and professionals. These models are ubiquitously being fine-tuned and applied across various fields such as healthcare, customer service and support, education, automated driving, and smart factories. This often leads to an increased level of complexity and challenges concerning the trustworthiness of these models, such as the generation of toxic content and hallucinations with high confidence leading to serious consequences. The European Union Artificial Intelligence Act (AI Act) is a regulation concerning artificial intelligence. The EU AI Act has proposed a comprehensive set of guidelines to ensure the responsible usage and development of general-purpose AI systems (such as LLMs) that may pose potential risks. The need arises for strengthened efforts to ensure that these high-performing LLMs adhere to the seven trustworthiness aspects (data governance, record-keeping, transparency, human-oversight, accuracy, robustness, and cybersecurity) recommended by the AI Act. Our study systematically maps research, focusing on identifying the key trends in developing LLMs across different application domains to address the aspects of AI Act-based trustworthiness. Our study reveals the recent trends that indicate a growing interest in emerging models such as LLaMa and BARD, reflecting a shift in research priorities. GPT and BERT remain the most studied models, and newer alternatives like Mistral and Claude remain underexplored. Trustworthiness aspects like accuracy and transparency dominate the research landscape, while cybersecurity and record-keeping remain significantly underexamined. Our findings highlight the urgent need for a more balanced, interdisciplinary research approach to ensure LLM trustworthiness across diverse applications. Expanding studies into underexplored, high-risk domains and fostering cross-sector collaboration can bridge existing gaps. Furthermore, this study also reveals domains (like telecommunication) which are underrepresented, presenting considerable research gaps and indicating a potential direction for the way forward. Full article

The global efforts to combat climate change, decarbonize the economies, and move towards a more sustainable future are focused on improving energy efficiency and reconfiguring the energy mix. Considering the impact on the environment and economic activity of energy production and consumption, this paper focuses on identifying the driving factors of final energy consumption in the European Union countries, which are undisputed leaders in the transition to a low-carbon economy. The goals of the paper are (1) to establish a model pattern that shows the relationships between the variation in final energy consumption and its driving forces and (2) to perform a comparative analysis to better understand the differences between the European Union (EU) economies in terms of energy efficiency improvement and decarbonization opportunities. Taking into consideration the objective of the research, comparative and correlation analyses were performed, and a decomposition technique (factorial analysis) was used in order to analyze the dynamic relationships between energy-related indicators for the EU as a whole and the 27 EU countries in 2023 compared to 2015. The research question is as follows: what are the main factors that generate final energy consumption in the EU? The hypothesis of this paper (H1) is that the variation in final energy consumption is determined by economic activity, lifestyle and consumer behavior, climate effect, and energy savings. This study’s main conclusions are that the variation in final energy consumption between 2015 and 2023 in EU countries was mostly due to key factors linked to economic activity, lifestyle and consumer behavior, climate effect, and energy savings. Thus, transport contributed the most to the variation in energy consumption, followed by services and manufacturing. The results indicate a shift to less energy-intensive sectors that positively impacted final energy consumption reduction, leading to energy savings. Concerning lifestyle and consumer behavior, household energy consumption had the highest contribution to the variation in energy consumption, followed by the number of passenger cars and the average annual net earnings. The climate effect was mostly due to the change in the cooling degree days that explained over 34.4% of the variation in the final energy consumption in households per capita. As for the energy savings effect, the results show that an increase in investments in the energy sector targeting efficiency improvements contributed to a reduction in energy consumption, leading to energy savings. Full article

Biological nitrogen (N) fixation has been advocated in agricultural fields due to being considered a more sustainable way to introduce N into agrosystems than industrial N fertilizers. In this study, a foliar spray inoculant containing the microorganism Methylobacterium symbioticum was applied. This microorganism is known for fixing N in the phyllosphere, regardless of the cultivated species. This study was conducted in three rainfed olive orchards over three years. In two orchards managed according to European Union (EU) integrated production rules, the experiment was organized as a factorial design with inoculant (applied at two levels, yes and no) and N fertilization (applied to the soil at three levels, 0, 40, and 80 kg ha⁻¹ of N). The third trial, managed according to EU organic farming rules, was organized in a completely randomized design with three treatments: with (yes) and without (no) inoculant and with a treatment involving a seaweed extract, also for foliar application. The microbiological inoculant did not consistently influence olive yield or N concentration in leaves across the three trials. Conversely, N application to the soil significantly influenced N concentration in leaves and olive yield. In one of the trials, in the third year of the study, soil N application (80 kg ha⁻¹) resulted in an olive yield of ~eight times higher than the unfertilized control treatment. The seaweed extract also did not lead to significant differences in leaf mineral composition or olive yield compared with the other treatments. These findings from the on-farm research highlight the importance of accurately determining the conditions under which commercial products can deliver effective results. It is crucial to acknowledge that these products involve expenses not only in their acquisition but also in their application. Full article

The authentication and dating of rare ceramics is generally carried out using subjective criteria, mainly based on visual interpretation. However, the scientific study and evaluation of the materials used could contribute objectively. The analytical data relating to the major and minor elements of the coloring agents of the decoration or the base marks, and the characteristics of the raw materials (related to geology and ore processing), can be obtained on the conservation site non-invasively using a pXRF instrument and the phases formed may be identified using Raman microspectroscopy. This approach is applied to 28 objects assigned to the production of the Meissen Factory, from the collection of the Musée National de Céramique, Cité de la Céramique, Sèvres. They have polychromic or blue-and-white decorations and are supposed to have been produced in the 18th and 19th centuries. Some have a production date that has been perfectly established, others may have been produced using an earlier mold, or even have been decorated on an unknown date different from that of the firing of the biscuit. The combination of several classification criteria concerning the type of glaze, previously identified in the study of French and Chinese 17th and 18th centuries productions, i.e., the elements associated with cobalt present in the mark or the blue decoration and the relative levels of impurities of the glaze matrix, both characteristic of the raw materials and giving a strong XRF signal, leads to the identification of groups of homogeneous objects (respectively, counting seven, three, two and two objects for which at least four out of five criteria are identical); the other objects present too many differences to be considered as having been produced with the same raw materials. The first group brings together almost all the objects with a reliable pedigree made before ~1750, but includes two objects with decoration types closer to those of the 1800s. The comparison of the pXRF signals confirms the possibility of identifying the use of European ingredients for the production of painted enamels in the Qing dynasty. Full article

By 2050, the European Union plans to make Europe the first carbon-neutral continent and a global leader in climate-green industries. Recently, many decisions have been taken in the world to ensure the energy transition from fossil fuel to renewable energy. The creation of renewable energy communities (REC) is among the solutions used to increase this transition. This study presents 16 different configurations for energy self-consumption in RECs containing different industrial factories. One mathematical model is proposed for each configuration, and they have been solved according to different criteria. The comparisons are made between these configurations according to economic, environmental, technical, and social criteria. Then, four multi-criteria decision-making (MCDM) methods are used to choose the best configurations considering all the criteria. For this purpose, the achieved results from the mathematical models are used as input for the MCDM methods. The findings demonstrate that the most effective configurations combine both individual and collective self-consumption. Furthermore, the inclusion of collective production results in multiple advantages, including a 64.71% rise in economic gains, a 26.95% decrease in CO₂ emissions, a 21.39% improvement in self-sufficiency, and a significant increase in job creation by 175.24%. In addition, incorporating storage enables a substantial rise in the degree of self-sufficiency, leading to reduced reliance on the power grid and consequent reduction in CO₂ emissions. Full article

The European standard EN 438-2 (2019) describes a method to assess the resistance to cracking of high-pressure laminate (HPL). In the EN 438-2 setup, the samples’ shrinkage at a temperature of 50 °C for 6 h is restrained by a metal clamp. The resulting tensile stress may lead to the cracking of the laminate. With the intention to gain additional insight into the parameters and influencing factors of the standard test, the resistance to cracking of 43 laminates was tested in accordance with the standard and with a prolonged testing time. Additionally, the tensile strength and shrinkage of the laminates were determined under the conditions of the standard test. The standard test uses free laminates (laminates not glued to a carrier board), so in order to correlate the results to applications that are close to real-life situations, four of the laminates were also tested when glued to carrier boards the size of furniture doors. In this full factorial test, particle board and gypsum board were used as carrier boards, UF and PVAc as adhesives, and the possible shrinkage of the laminates was adjusted by two moisture conditions of the laminates. The resistance to cracking in the standard test turned out to be mainly influenced by the composition of the laminate. Thin laminates with a pure paper backing were especially prone to cracking in the setup. Within the 6 h storage at 50 °C of the standard test, the laminates did not reach moisture equilibrium. Prolonged storage at 50 °C until equilibrium was reached (which took up to 10 days) allowed an improved differentiation of the cracking resistance, especially of thicker laminates. Four of the laminates were also tested on wooden and mineral-based carrier boards with either PVAc or UF as adhesive and two moisture contents of the laminates. The following parameters were identified as a critical combination for cracking: laminate with a low cracking resistance according to the EN 438-2 test in combination with a non-hygroscopic mineral-based carrier board, increased moisture of the laminate before being glued on the board, and the use of PVAc adhesive. Full article

Prostate cancer (PCa) is reported as the most common malignancy and second leading cause of death in America. In Europe, PCa is considered the leading type of tumour in 28 European countries. The costs of treating PCa are currently increasing more rapidly than those of any other cancer. Corresponding economic burden is enormous, due to an overtreatment of slowly developing disease on one hand and underestimation/therapy resistance of particularly aggressive PCa subtypes on the other hand. The incidence of metastatic PCa is rapidly increasing that is particularly characteristic for young adults. PCa is a systemic multi-factorial disease resulting from an imbalanced interplay between risks and protective factors. Sub-optimal behavioural patterns, abnormal stress reactions, imbalanced antioxidant defence, systemic ischemia and inflammation, mitochondriopathies, aberrant metabolic pathways, gene methylation and damage to DNA, amongst others, are synergistically involved in pathomechanisms of PCa development and progression. To this end, PCa-relevant systemic effects are reflected in liquid biopsies such as blood patterns which are instrumental for predictive diagnostics, targeted prevention and personalisation of medical services (PPPM/3P medicine) as a new paradigm in the overall PCa management. This strategic review article highlights systemic effects in prostate cancer development and progression, demonstrates evident challenges in PCa management and provides expert recommendations in the framework of 3P medicine. Full article

The article presents laboratory tests on the impact of the mixing water content used in the preparation of fresh mortar on the flexural and compressive strength of one of the dry-mix mortars produced by a leading European producer and dedicated to bricklaying with clinker elements. The development of these parameters in relation to curing time was also analyzed. The mortar samples were prepared from a factory-made mortar mix using 4.0 L (the value recommended by the mortar manufacturer), 4.5 L, and 5 L of water per 25 kg bag of ready-made, pre-mixed dry mortar mix. All samples were tested in five series after 5, 9, 14, 21, and 28 days of sample curing. The results of these tests showed that the use of 6 and 18% more mixing water than recommended by the manufacturer (4.5 and 5 L per bag) adversely affected the basic mechanical parameters of the tested mortar. Moreover, it was found that the highest compressive strength values were obtained after 21 days of curing and not after 28 days as usual. It was also found that hardening time and higher than recommended water content adversely affected the bending strength of the mortar. Full article

(1) Background: contact between indigenous and European populations has often resulted in changes in oral health attributed to the introduction of sucrose. Most studies are per tooth over considerable periods and with few ethnological references. (2) Aim: dental epidemiology of 96 autochthonous frozen bodies from Yakutia between the early 17th century and the late 19th century; comparisons with historical texts and ethnographic data. (3) Material and methods: we use descriptive statistics and discriminant factorial analyses to identify dominant variables in the dataset and compare periods and subjects, considering all variables. (4) Results: the peculiarities of the population are the rarity of cavities and the relative frequency of dental pathologies leading to death. Assimilation into the Russian Orthodox culture has led to decreased tooth wear and an increase in tooth loss. Dental health evolves only two centuries after the contact. (5) Conclusions: the confrontation with historical data suggests that changes are not related to the growing importance of sucrose but to a combined action: the substitution of dendrophagy by cereal flour; the decrease in immunity linked to the development of chronic infectious diseases; tobacco addiction and the mandibular torus: a risk factor promoting apical cysts. Full article

Sustainability is a complex concept. It only can be achieved from a global perspective, where social, economic and environmental issues are all key factors for achieving the goal. This paper is focused on the importance of social sustainability and, as a consequence, the importance of avoiding each and everyone’s risk of poverty and exclusion as due to the recent crisis effects. Nevertheless, this crisis resulted in higher inequalities and put a lot of people at risk of poverty, even in “developed” countries. Through a statistical and econometric analysis, some of the key factors to which the European Union should aim to avoid unsustainable scenarios are analysed. A regression, factorial and cluster analysis is carried out and this leads to conclude that the labour market is key in promoting economic policies in order to achieve social sustainability. Full article

Despite the great contribution of natural products in the history of successful drug discovery, there are significant limitations that persuade the pharmaceutical industry to evade natural products in drug discovery research. The extreme scarcity as well as structural complexity of natural products renders their practical synthetic access and further modifications extremely challenging. Although other alternative technologies, particularly combinatorial chemistry, were embraced by the pharmaceutical industry to get quick access to a large number of small molecules with simple frameworks that often lack three-dimensional complexity, hardly any success was achieved in the discovery of lead molecules. To acquire chemotypes beholding structural features of natural products, for instance high sp³ character, the synthesis of compound collections based on core-scaffolds of natural products presents a promising strategy. Here, we report a natural product inspired synthesis of six different chemotypes and their derivatives for drug discovery research. These bicyclic hetero- and carbocyclic scaffolds are highly novel, rich in sp³ features and with ideal physicochemical properties to display drug likeness. The functional groups on the scaffolds were exploited further to generate corresponding compound collections. Synthesis of two of these collections exemplified with ca. 350 compounds are each also presented. The whole compound library is being exposed to various biological screenings within the European Lead Factory consortium. Full article