Search Results (64)

Hot water extraction (HE), enzyme-assisted hot water extraction (EAHE), ultrasonic-assisted extraction with NADES (UAE-NADES) and ultrasonic-assisted extraction with NADES and enzyme pretreatment (UAE-NADES-E) were employed to extract polysaccharides from Peucedani Decursivi Radix (PDR) and their structures were characterized for the first time. UAE-NADES-E was found to be the most effective extraction method, and the extraction process was optimized by Box–Behnken design (BBD)-response surface methodology (RSM) experiments. The optimal extraction process was determined by using a NADES system with a molar ratio of betaine to 1,3-butanediol of 1:3, a water content of 30%, a liquid/solid ratio of 40:1 mL/g, an ultrasound time of 30 min, an ultrasound temperature of 45 °C and an alcohol precipitation time of 6 h; the polysaccharide extraction yield reached 19.93%. Further, the structures of polysaccharides from PDR extracted by the above four methods were characterized by FT-IR, SEM, gel and anion-exchange chromatography. Eight monosaccharides were detected in the PDR polysaccharides extracted by the four methods. The PDR polysaccharides extracted by the UAE-NADES-E method had lower molecular weights compared with those extracted by the other methods. Moreover, the PDR polysaccharides exhibited obvious antioxidant activity, as revealed by DPPH, ABTS+ and hydroxyl radical scavenging experiments, meaning they have the potential to be developed as natural antioxidants. Full article

Chronic alcohol consumption is a major contributor to gastric injury, yet current therapeutic strategies predominantly rely on chemical agents with limited efficacy and potential side effects. Natural products, with their multi-target biocompatibility and safety advantages, offer promising alternatives for gastric protection. We examined the phenolic compounds of Elaeagnus angustifolia honey (EAH) and investigated its prophylactic potential against ethanol-induced chronic gastric injury in mice. HPLC-DAD-Q-TOF-MS analysis showed that 21 phenolic compounds were tentatively and qualitatively identified in EAH, as well as 14 phenolic compounds. Moreover, gastric ulcer indices, histopathological morphology, oxidative stress markers (MDA, GSH, SOD), inflammatory mediators (NO, PGE2), and cytokine gene expression (TNF-α, IL-6, IL-1β, iNOS) were evaluated via enzyme-linked immunosorbent assay (ELISA) and quantitative real-time PCR. Western blot was employed to assess COX-2 protein expression, while 16^S rRNA sequencing analyzed gut microbiota composition. The results demonstrated that EAH could play a role in gastric injury caused by long-term alcoholism by protecting gastric tissue structure, interfering with oxidative stress and inflammatory response, and remodeling the intestinal microbial community. Full article

A data-driven 3D simulation for the robotic automation of the most labor-intensive packaging process in meal kit production was developed using Tecnomatix plant simulation software. The workflow and environments of the existing manual process were analyzed. An existing production site was scanned using a 3D Lidar scanner to create 3D models and design the initial assembly layout. Two types of 3D simulation models, implemented with a single or double delta robot, were designed to determine the optimal robot-automated packaging process. Key performance indicators for simulation models of a manual and two robot automation systems were analyzed. The throughputs of the manual, single delta robot and double delta robot models were 2112, 1510, and 2568 ea/h, respectively. The single robot system achieved only 68.3% of the throughput of the manual process, which is attributed to a cycle time of 2.36 s for picking and placing all components. On the other hand, the cycle time of the double robot system was 1.66 times faster, and the throughput was 1.7 times greater compared to the single robot system. The developed 3D simulation model for the meal kit packaging system demonstrates the potential of robotic automation in addressing the labor shortage issue as well as improving production efficiency. Full article

Background/Objectives: This study examines the relationship of eating in the absence of hunger (EAH) with child sex, food preference, and body mass index (BMI) percentiles in primarily Hispanic preschoolers, an understudied population. Methods: This was a secondary analysis of data from 211 children (79% Hispanic) aged 3 to 5 years from low-income families who completed a cluster randomized controlled trial from September 2017 to June 2020. Weight and height were used to calculate BMI percentiles. Sweet (animal crackers) and salty (pretzels) snacks were used to conduct a validated classroom-based EAH assessment. A generalized estimating equation (GEE) approach investigated associations between the grams of snacks consumed and BMI percentiles. A set of nested multivariable GEEs were estimated, while adjusting for potentially important covariates. Results: Boys significantly consumed more snacks than girls (13.34 ± 9.71 g vs. 8.13 ± 7.36 g; p < 0.001). Children who indicated greater preference for sweet snacks consumed more sweet snacks (r = 0.19; b = 2.05, p < 0.001) and total grams of total snacks (r = 0.18; b = 2.42, p = 0.004) but not salty snacks (pretzels). Consuming more sweet snacks was significantly associated with higher BMI percentiles (b = 0.55; p = 0.024). Conclusions: The findings suggest that a preference for sweet snacks is associated with EAH, and eating sweet snacks in the absence of hunger is related to higher BMI percentiles. Obesity prevention programs may focus on addressing eating sweet snacks in the absence of hunger starting in early childhood. Full article

Earth–Air Heat Exchange (EAHE) systems are an eco-friendly and energy-efficient technology as pre-heating or pre-cooling systems in civil buildings. Technically, the performance of the EAHE system is influenced by properties associated with the technology. In this paper, the focus is placed on the properties covered by the published literature to understand how they impact the efficiency of these systems. The review scrutinizes the implication of pipe properties such as the material type (steel, Polyvinyl Chloride [PVC], concrete, or high-density polyethylene), diameter and length, and depth in the context of modern building design and energy conservation. Other properties considered in this work are air velocity and the bonding of pipes with the soil. The EAHE systems’ performance is not significantly influenced by the pipe material, unlike the pipe length and diameter. It is reported that longer pipes enhance the cooling output in the EAHE system. The pipe length positively correlates with the in-pipe air temperature. An increment in the pipe diameter led to a drop in the in-pipe air temperature. An indicative report states that an increasing air flow velocity can lead to thermal losses from pipes to their surrounding soil. The addition of sand below and above the pipe enhances the thermal conductivity, just as an increase in the moisture content of the soil will contribute. There are attempts to use additives, construction waste, graphite, and fly ash as a backfill material, but with opposing economic feasibility. Construction waste could help the EAHE system to improve by 80%. A combination of graphite and fly ash as a backfill material is cost-effective. Research on the pipe material type and standards development are limited. Overall, the pipe material type and length to adopt for an EAHE system are based on the funds’ availability for the construction. Full article

Earth-Air Heat Exchangers (EAHEs) provide a compelling solution for improving building energy efficiency by harnessing the stable subterranean temperature to pre-treat ventilation air. This comprehensive review delves into the foundational principles of EAHE operation, meticulously examining heat and mass transfer phenomena at the ground-air interface. This study meticulously investigates the impact of key factors, including soil characteristics, climatic conditions, and crucial system design parameters, on overall system performance. Beyond independent applications, this review explores the integration of EAHEs with a diverse array of renewable energy technologies, such as air-source heat pumps, photovoltaic thermal (PVT) panels, wind turbines, fogging systems, water spray channels, solar chimneys, and photovoltaic systems. This exploration aims to clarify the potential of hybrid systems in achieving enhanced energy efficiency, minimizing environmental impact, and improving the overall robustness of the system. Full article

Ultra-trail events (UTs) pose significant challenges to maintaining hydration and electrolyte balance, with risks of dehydration (DH), overhydration (OH), exercise-associated hyponatremia (EAH), and exertional rhabdomyolysis (ER). This study examined the effects of ad libitum (ADL) hydration on hydration status and muscle damage during a nine-stage UT (635 km, 40,586 m elevation gain). Four highly trained male athletes participated. Hydration was assessed via body weight loss (BWL), urine specific gravity (U_sg), and serum sodium ([Na+]), while muscle damage markers included creatine kinase (CK), lactate dehydrogenase (LDH), and calcium (Ca), and liver damage biomarkers included aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Our results showed no cases of EAH or hypernatremia ([Na+] > 145 mmol·L⁻¹), with serum [Na+] maintained above 135 mmol·L⁻¹. BWL exceeded the 2% DH threshold in early stages (p = 0.029), and U_sg remained elevated (>1.020 g·mL⁻¹). LDH and CK significantly increased at all stages (p < 0.05), persisting for 48 h post-event. Correlations showed BWL aggravated muscle damage (r = 0.47 with CK) and hypocalcemia (r = −0.68 with Ca). Elevation gain/loss amplified fluid loss and muscle injury. While ADL hydration mitigated EAH, it did not fully address DH or muscle damage. Personalized hydration and recovery protocols are crucial to optimizing performance and health in UT events. Full article

Exercise-associated hyponatremia (EAH) is commonly observed in endurance athletes, where prolonged physical exertion combined with being unaware of personal hydration needs can lead to excessive water consumption or inadequate sodium intake. Marching band (MB) is an emerging setting for sports medicine professionals. However, there is little research on non-musculoskeletal illnesses among these performing artists. This study is part of a larger cross-sectional study and seeks to examine whether MB artists have previously experienced EAH and the presence of known EAH risk factors (e.g., pre-existing medical conditions, medication use, nutritional behaviors). Active collegiate MB members (n = 1207; mean age = 19.6 ± 1.3 years) completed an online survey that characterized demographics, medical history, and nutrition behaviors. Statistical analyses included descriptives (mean, standard deviation) and frequencies for all data. Binomial logistic regressions analyzed the relationship and determined the odds ratio (OR) between previous EAH and EAH risk factors. Participants were from 23 different states, predominately White (82.9%), female (56.7%), and at NCAA Division I institutions (92%). A total of 74 (6.1%) participants reported previously experiencing EAH, 32 (43.2%) within the past year. Previous EAH occurrence was greatest among individuals who had kidney conditions (χ²(1) = 5.920, R² = 0.013, OR = 15.708, p = 0.015); mood/neurological conditions (χ²(1) = 7.508, R² = 0.017, OR = 2.154, p = 0.006), particularly anxiety (χ²(1) = 7.651, R² = 0.017, OR = 3.590, p = 0.006); used mental health medications (χ²(1) = 7.512, R² = 0.017, OR = 2.220, p = 0.006), particularly selective serotonin reuptake inhibitors (χ²(1) = 13.502, R² = 0.030, OR = 3.297, p < 0.001); and who dieted (χ²(1) = 6.121, R² = 0.014, OR = 1.913, p = 0.013) or perceived they had an eating disorder (χ²(1) = 9.502, R² = 0.021, OR = 2.729, p = 0.002). Healthcare providers should be aware that MB artists may have pre-existing medication conditions, use medication, and have inadequate nutrition. Targeted hydration and nutritional education for MB artists is essential for effective prevention and early EAH recognition, improving health and performance for MB artists within demanding environments. Full article

This study systematically explored the characteristics of explosion and pressure fluctuations of ethyl acetate (EA)/hydrogen (H₂)/air mixtures under different initial pressures (1–3 bar), H₂ fractions (4%, 8%, 12%), and equivalence ratios of EA (0.5–1.4). The flame images indicated that a higher pressure, a higher H₂ fraction, and a higher equivalence ratio could cause flame instability. An analysis of the dimensionless growth rate indicated that the flame instability was impacted by both thermal diffusion and hydrodynamic effects. The results also indicated that a higher initial pressure or H₂ fraction could accelerate the combustion reaction and increase the explosion pressure and deflagration index. The maximum values were observed at 21.841 bar and 184.153 bar·m/s. However, their effects on explosion duration and heat release characteristics differed between lean and rich mixtures. Additionally, this study examined pressure fluctuations in both the time and frequency domains. The findings indicated a strong correlation between pressure fluctuation and flame instability. Modifying the H₂ fraction and equivalence ratio to enhance flame stability proved effective in reducing pressure fluctuation amplitude. This study offers guidance for evaluating explosion risks associated with EA/H₂/air mixtures and for designing related combustion devices. Full article

The complex dielectric permittivity, ε (f, H) = ε′ (f, H) − i ε″ (f, H), in the microwave frequency range f, of (0.1–3) GHz and polarizing field values H, in the range of (0–135) kA/m, was measured for a kerosene-based ferrofluid with magnetite particles. A relaxation process attributed to interfacial type relaxation was highlighted, determining for the first time in the microwave field, the activation energy of the dielectric relaxation process in the presence of the magnetic field, E_A(H), in relation to the activation energy in zero field, E_A(H = 0). Based on the complex permittivity measurements and the Claussius–Mossotti equation, the dependencies on frequency (f), and magnetic field (H), of the polarizability (α) and electrical conductivity (σ), were determined. From the dependence of α(f,H), the electric dipolar moment, p, of the particles in the ferrofluid, was determined. The conductivity spectrum, σ(f,H), was found to be in agreement with Jonscher’s universal law and the electrical conduction mechanism in the ferrofluid was explained using both Mott’s VRH (variable range hopping) model and CBH (correlated barrier hopping) model. Based on these models and conductivity measurements, the hopping distance, R_h, of the charge carriers and the maximum barrier height, W_m, for the investigated ferrofluid was determined for the first time in the microwave field. Knowledge of these electrical properties of the ferrofluid in the microwave field is useful for explaining the mechanisms of polarization and control of electrical conductivity with an external magnetic field, in order to use ferrofluids in various technological applications in microwave field. Full article

Endometrial atypical hyperplasia (EAH) is a premalignant condition with a substantial risk of progression to endometrial cancer (EC), with the endometrioid subtype being the most common. EAH is characterized by abnormal endometrial gland proliferation and cellular atypia, often resulting from prolonged unopposed estrogen exposure. This review aims to explore the clinical significance of EAH, its risk of progression to EC, and the current approaches to management. The risk of EAH progressing to EC ranges from 20 to 50%, influenced by factors such as histopathology and genetic mutations including PTEN and KRAS. Key risk factors include obesity, polycystic ovary syndrome, and postmenopausal status. Abnormal uterine bleeding is a hallmark symptom of EAH and early-stage EC, necessitating diagnostic evaluation through endometrial biopsy and transvaginal ultrasonography. Therapeutic management strategies depend on patient risk and fertility considerations. Hormonal therapy, particularly progestins, is the mainstay for fertility preservation, while hysterectomy is preferred for higher-risk patients. Regular monitoring with biopsies is essential for those undergoing conservative treatment. Recent advancements in the management of EAH and EC have shifted towards incorporation of molecular diagnostics and targeted therapies, enabling better risk stratification and individualized care. Biomarkers and minimally invasive surgical techniques are emerging as promising approaches in improving outcomes for women with EAH. This review underscores the importance of early diagnosis and personalized management in preventing the progression of EAH to EC, highlighting current clinical practices and potential future developments in this field. Full article

This study presents a numerical evaluation of a Horizontal Rectilinear Earth–air Heat Exchanger (EAHE), considering the climatic and soil conditions of Viamão, Brazil, a subtropical region. The Constructal Design method, combined with the Exhaustive Search, was utilized to define the system constraints, degree of freedom, and performance indicators. The degree of freedom was characterized by the aspect ratio between the vertical and horizontal lengths of the elliptical cross-section duct (H/L). The performance indicators for the EAHE configurations were assessed based on thermal potential (TP) and pressure drop (PD). The Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) was applied for multi-objective evaluation, and a methodology for EAHE is proposed. The problem was solved using FLUENT software (version 2024 R2), which employs the Finite Volume Method to solve the conservation equations for mass, momentum, and energy. The (H/L)_T,o = 6.0 configuration showed a 16.4% increase in thermal performance for heating and 15.9% for cooling compared to the conventional circular duct. Conversely, the (H/L)_F,o = 1.0 configuration reduced pressure loss by 65.33%. The integration of Constructal Design with TOPSIS facilitated the identification of optimized geometries that achieve a balance between performance indicators and those that specifically prioritize thermal or fluid dynamic aspects, being this approach an original scientific contribution of the present work. Full article

This article investigates the status of earthen architectural heritage (EAH) in the Gourara region of Algeria in light of contemporary developments and the sovereign decisions taken by the Algerian state, specifically the upgrading of the region to a wilaya (province) in 2019, and the accompanying direct impact on the oasis system, which is renowned for its fragile character. The research started by focusing on perplexing questions: What factors contribute to the region’s abandonment of earthen architecture? Moreover, could documentation serve as the optimal method for its preservation? In an attempt to explore and comprehend this distinctive heritage, characterized by its diversity, durability, and sustainability, this heritage has been linked to identity and local civilization dating back to prehistoric times, with evidence of their existence still present. Following a research approach and with the prospective purpose of preserving these buildings and what remains of them, the associated skills, materials, and construction techniques used in their development were investigated based on a descriptive, analytical, and documentary historical approach. Finally, the authors interviewed several qualified builders to collect knowledge of the local indigenous building practices. The research findings suggest that there is an urgency to consider a new perspective and strategies to preserve and protect EAH. Full article

A novel high-efficiency industrialized clean production technology based on multi-stage gradient batching and smelting was proposed for the production of high-quality ferrovanadium. The thermodynamic mechanism of aluminothermic reduction equilibrium, alloy settlement and raw material impurity distribution were confirmed, and a multi-stage double-gradient aluminum addition pattern (DG-ADP), the highly efficient separation of molten slag and alloy, and typical impurity control standards of raw materials were achieved on the basis of a self-propagating high-temperature synthesis with an electric auxiliary heating (SHS-EAH) process. The reduction efficiency, separation efficiency and the comprehensive utilization rate of the secondary resources were significantly improved, as the whole total vanadium (T.V) content in the industrially produced residue slag reduced from 2.34 wt.% to 0.60 wt.%, while the corresponding smelting yield increased from 93.7 wt.% to 98.7 wt.% and the aluminum consumption decreased from 510 kg·t⁻¹ to 400 kg·t⁻¹. The multi-stage DG-ADP process enabled the internal circulation of vanadium-bearing materials in the ferrovanadium smelting system, as well as the external circulation of iron and residue slag in the same system, and finally achieved the zero discharge of solid and liquid waste from the ferrovanadium production line, which provides a brand-new perspective for the cleaner production of ferrovanadium alloy. Full article

The refurbishment of a social interest building using Earth-to-Air Heat Exchanger (EAHE) was studied in representative dry climatic conditions of Mexico (dry, very dry, temperate, and sub-temperate). A simulation method that uses both computational fluid dynamics (CFD) and building energy simulation (BES) was used to analyze the influence of the EAHE on the indoor conditions of a room. First, CFD simulations of the EAHE were performed using climatic data and soil properties of the four representative cities, and then the results were loaded into the TRNSYS software to estimate the indoor air temperature and the building room’s thermal loads. When connected to a building room on a warm day, the EAHE reduced the indoor air temperature by a factor ranging between 1.7 and 3.2 °C, while on a cold day, the EAHE increased the indoor air temperature of the room by between 1.0 and 1.9 °C. On the other hand, the EAHE reduced the daily cooling load of the room by a factor between 2% and 6%. The EAHE also reduced the daily heating load by between 0.3% and 11%. Thus, EAHE as a refurbishment technology can benefit social interest buildings in Mexico. Full article