Search Results (157)

Throughout history, communities have struggled to build homes in places actively hostile to their presence, a challenge long faced by African descendants in the American diaspora. In cities across the U.S., including Washington, D.C., efforts have often been made to erase Black cultural identity. D.C., once a hub of Black culture, saw its urban fabric devastated during the 1968 riots following Dr. Martin Luther King Jr.’s assassination. Since then, redevelopment has been slow and, more recently, marked by gentrification, which has further displaced Black communities. Amid this context, Black architects such as Michael Marshall, FAIA, and Sean Pichon, AIA, have emerged as visionary leaders. Their work exemplifies Value-Inclusive Design and aligns with Roberto Verganti’s Design-Driven Innovation by embedding cultural relevance and community needs into development projects. These architects propose an intentional approach that centers Black identity and brings culturally meaningful businesses into urban redevelopment, shifting the paradigm of design practice in D.C. This collective case study (methodology) argues that their work represents a distinct architectural style, Black Modernism, characterized by cultural preservation, community engagement, and spatial justice. This research examines two central questions: Where does Black Modernism begin, and where does it end? How does it fit within and expand beyond the broader American Modernist architectural movement? It explores the consequences of the destruction of Black communities, the lived experiences of Black architects, and how those experiences are reflected in their designs. Additionally, the research suggests that the work of Black architects aligns with heutagogical pedagogy, which views community stakeholders not just as beneficiaries, but as educators and knowledge-holders in architectural preservation. Findings reveal that Black Modernism, therefore, is not only a design style but a method of reclaiming identity, telling untold histories, and building more inclusive cities. Full article

The renin–angiotensin system (RAS) plays a central role in cardiovascular regulation and has gained prominence in the pathogenesis of Coronavirus Disease 2019 (COVID-19) due to the critical function of angiotensin-converting enzyme 2 (ACE2) as the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin IV, but not angiotensin II, has recently been reported to enhance the binding between the viral spike protein and ACE2. To investigate the virological significance of this effect, we developed a single-round infection assay using SARS-CoV-2 viral-like particles expressing the spike protein. Our results demonstrate that while angiotensin II does not affect viral infectivity across concentrations ranging from 40 nM to 400 nM, angiotensin IV enhances viral entry at a low concentration but exhibits dose-dependent inhibition at higher concentrations. These findings highlight the unique dual role of angiotensin IV in modulating SARS-CoV-2 entry. In silico molecular docking simulations indicate that angiotensin IV was predicted to associate with the S1 domain near the receptor-binding domain in the open spike conformation. Given that reported plasma concentrations of angiotensin IV range widely from 17 pM to 81 nM, these levels may be sufficient to promote, rather than inhibit, SARS-CoV-2 infection. This study identifies a novel link between RAS-derived peptides and SARS-CoV-2 infectivity, offering new insights into COVID-19 pathophysiology and informing potential therapeutic strategies. Full article

Fifty million Americans, nearly 15% of the population, live below the federal poverty level, often facing civil legal issues without representation. Historically Black Colleges and Universities (HBCUs) have long served as economic engines and vital resources for their communities. HBCU law schools uphold this legacy by preparing students for legal careers while instilling a commitment to service, particularly for underserved citizens who lack access to quality legal representation. This research examines the dual mission of HBCU law schools—educating students and serving local communities—through a systematic document analysis of publicly available materials and literature on law school clinical programs. The findings identify four key community performance indicators that define the community impact of HBCU law schools: advocacy, engagement, client outcomes, and representation. These indicators reflect a shared commitment across all institutions to addressing systemic inequities through clinical legal education, reinforcing the role of HBCU law schools as both training grounds for future attorneys and essential pillars of justice in their communities. Full article

Treatment for HIV infection has become more manageable due to advances in combination antiretroviral therapy (cART). However, HIV still significantly affects the central nervous system (CNS) in infected individuals, even with effective plasma viral suppression, due to persistent viral reservoirs and chronic neuroinflammation. This ongoing inflammation contributes to the development of HIV-associated neurocognitive disorders (HANDs), including dementia and Alzheimer’s disease-like pathology. These complications are particularly prevalent among the aging population with HIV. This review aims to provide a comprehensive overview of HAND, with a focus on the contribution of oxidative stress induced by HIV-mediated reactive oxygen species (ROS) production through viral proteins such as gp120, Tat, Nef, Vpr, and reverse transcriptase. In addition, we discuss current and emerging therapeutic interventions targeting HAND, including antioxidant strategies and poly (ADP-ribose) polymerase (PARP) inhibitors. These are potential adjunctive approaches to mitigate neuroinflammation and oxidative damage in the CNS. Full article

The presence of hope significantly influences how youth interpret possibilities and commit to future-oriented action. This qualitative study investigates how fifteen Black emerging adults, ages eighteen to twenty-five, living in a major United States urban city on the East Coast, describe their aspirations, goal-setting strategies, and responses to personal and structural challenges. Participants were categorized as connected or disconnected based on their engagement in school, work, or training programs. Using Reflexive Thematic Analysis of interviews, the research identified key differences in agency, emotional orientation, and access to guidance between the two groups. Connected participants often described clear, structured goals supported by networks of mentorship and opportunity. Disconnected participants expressed meaningful hope, yet described fewer supports and greater uncertainty in achieving their goals. These findings highlight how consistent exposure to guidance and structured environments strengthens future orientation and internal motivation. These results deepen our understanding of how young people experience hope across diverse contexts and show that mentorship, intentional goal setting, and greater access to opportunity play a vital role in sustaining hopeful thinking during the transition to adulthood. Full article

This community-based participatory research (CBPR) study explored, using a Photovoice methodology, the lived expeiences of northeastern Black and/or African American youth and mothers who were currently experiencing the incarceration of their fathers and husbands. Grounded in critical theories of dual consciousness and comparative conflict, the findings provide valuable insights into how this population navigates the intersections of family, school, and community within the context of the criminal legal system, and, in the process, underscore the relevance of Abolitionist practice in capturing their theoretically lived experiences. Participants documented through photography and narrative reflections the multifaceted impacts of incarceration on fathers and husbands, including disrupted family dynamics, social stigma, and barriers to community resources. A focus group with the mothers of these youth highlighted the profound impact of incarceration on their family structure, revealing significant emotional burdens for caregivers as well as personal changes to parenting styles as a result of this project. A central theme that emerged was the development of a “double” or “dual consciousness”—an ability to see humanity and injustice in their circumstances, fueling a desire for systemic change. Overall, this CBPR project amplifies the voices of marginalized youth and mothers, illuminating how the criminal legal system perpetuates cycles of trauma, stigma, and disempowerment. The implications call for a radical reimagining of the role of social work in creating more equitable, restorative, and healing-centered communities, including an immediate embrace of Abolitionist practice concepts and interventions. Full article

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for Coronavirus Disease 2019 (COVID-19), utilizes its spike protein to infect host cells. In addition to angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1), AXL acts as a spike protein receptor and mediates infection, especially in respiratory cells with low ACE2 expression. Angiotensin II (1–8) can be cleaved into shorter peptides within the biological system. Antibody-based binding assays showed that angiotensin II causes a two-fold increase in the binding between the spike protein and AXL, but not ACE2 or NRP1. While a longer peptide, angiotensin I (1–10), did not affect the spike–AXL binding, shorter lengths of angiotensin peptides exhibited enhancing effects. The C-terminal deletions of angiotensin II to angiotensin (1–7) or angiotensin (1–6) resulted in peptides with enhanced activity toward spike–AXL binding with a similar capacity as angiotensin II. In contrast, the N-terminal deletions of angiotensin II to angiotensin III (2–8) or angiotensin IV (3–8) as well as the N-terminal deletions of angiotensin (1–7) to angiotensin (2–7) or angiotensin (5–7) produced peptides with a more potent ability to enhance spike–AXL binding (2.7-fold increase with angiotensin IV). When valine was substituted for tyrosine at position 4 in angiotensin II or when tyrosine at position 4 was phosphorylated, spike–AXL binding was increased, suggesting that modifications to tyrosine trigger enhancement. Angiotensin IV also enhances spike protein binding to ACE2 and NRP1. Thus, angiotensin peptides may contribute to COVID-19 pathogenesis by enhancing spike protein binding and thus serve as therapeutic targets. Full article

During the intense heatwaves of late summer 2024, Washington, D.C.’s urban landscape revealed the powerful influence of urban morphology on microclimates and air quality. This study investigates the impact of building height-to-width (H/W) ratios on the urban heat island (UHI) effect, using a combination of field measurements and Computational Fluid Dynamics (CFD) simulations to understand the dynamics. Street-level data collected from late August to November 2024 across three sites in Washington, D.C., indicate that high H/W ratios (1.5–2.0) increased temperatures by approximately 2–3 °C and reduced wind speeds to around 0.8 m/s. These conditions led to elevated pollutant concentrations, with ozone (O₃) ranging from 1.8 to 7.3 ppb, nitrogen dioxide (NO₂) from 0.3 to 0.5 ppm, and carbon monoxide (CO) remaining relatively constant at approximately 2.1 ppm. PM_2.5 concentrations fluctuated between 2.8 and 0.4 $\mathsf{\mu }$g/m³. Meanwhile, lower H/W ratios (less than 1.5) demonstrated better air circulation and lower pollution levels. The CFD simulations are in agreement with the experimental data, yielding an RMSE of 0.75 for temperature, demonstrating its utility for forecasting UHI effects under varying urban layouts. These results demonstrate the potential of Computational Fluid Dynamics in not only modeling but also predicting UHI dynamics. Full article

In the aging population, imbalance leading to falls is of critical concern; thus, it is imperative to determine and quantify neuromuscular changes because of rehabilitative balance training. (1) Background: Previous studies that have examined changes in balance due to rehabilitative training placed a focus on clinical measures (i.e., behavioral, kinetic, and kinematic outputs); however, irregularities due to abnormalities of underlying neural origin were unrevealed by the aforementioned measures. (2) Methods: Examining muscle activity was used to determine strategies pre- and post-six weeks of balance training in twenty-three healthy older adults (69.5 ± 5.7 years old) and five survivors of stroke (66.4 ± 9.48 years old). Surface electromyographic (sEMG) signals were recorded from eight of the lower limb muscles while participants performed forward walking (FW), forward tandem walking (FT-W), backward walking (BW), and backward tandem walking (BT-W) tasks. The sEMG data were then conditioned and muscle synergies were extracted using non-negative matrix factorization (NNMF). (3) Results: It was observed that muscle synergies and activation patterns changed for pre- versus post-balance training in older adults (i.e., healthy individuals and those who had suffered from stroke). (4) Conclusions: From our findings, it was indicative that muscle activation and muscle synergies could be used to quantify and inform rehabilitative balance training in older adults. Full article

Falls are the leading cause of injury and mortality among older adults—one in four individuals 65 years old and above experiences falls. Thus, balance training interventions that improve balance ability and reduce the risk of falls are of critical importance. Through two complementary interventions, our research sought to determine the effects of Virtual Reality (VR) compared to Robotic-Assisted Balance Training (RABT) on balance ability and balance confidence in older adults. The VR intervention utilized Oculus headsets to create immersive balance exercises, while the RABT employed a multidirectional overground robotic system (NaviGAITor). Participants (aged 60–85 years old) underwent a 6-week training protocol consisting of two 30 min sessions per week. Balance ability was quantified using center of pressure (COP) parameters and the Balance Error Scoring System (BESS), while balance confidence was measured using the Activities-Specific Balance Confidence (ABC) scale. Results indicated no statistically significant differences between the training methods. However, the RABT group showed trends toward enhanced balance performance, with observed decreases in mediolateral (ML) maximum displacement during wide stance conditions and reductions in BESS errors on both firm and foam surfaces. The VR group demonstrated significant changes in ML RMS values during tandem stance (p = 0.045) and improved participants’ relationship with perceived and actual balance ability (increased correlation between BESS errors and ABC scores from R² = 0.00 pre-training to R² = 0.65 post-training). Balance confidence did not significantly increase in either group. These findings suggest that while RABT may trend toward improvements in objective balance parameters, VR training appears to enhance participants’ perceptual accuracy of their balance capabilities. Full article

Marijuana legalization has been at the center of debate in the social and political realm of the United States. So far, thirty nine states and the District of Columbia have legalized marijuana either for recreational or medical purposes. States are taking a cautious approach to legalization in a policy context consisting of multi-layered sociopolitical systems. Strong arguments from advocacy groups supporting and opposing legalization highlight the significance of assessing the impact of marijuana use and its legalization on the well-being of the community and its members. Utilizing the social determinants of health and system perspectives, this study measures the cumulative effect of six socio-ecological and economic predictors, such as the state’s marijuana use prevalence and median household income, on the dependent variable of marijuana legality scores using discriminant analysis and One-way ANOVA. As hypothesized, the result shows a significant influence of the predictors on the state policy score of marijuana legality. Predicted associations between independent and dependent variables were also found. Findings suggest that without a supportive policy context comprising social, economic, and political factors, marijuana legalization might not have the desired impact on the community. Implications and recommendations for future research are provided. Full article

Background: The global outbreak of Coronavirus Disease 2019 (COVID-19) has significantly altered everyday routines, even influencing dietary behaviors and food choices. This study aimed to investigate the impact of the COVID-19 pandemic on changes in the consumption of various food sources and to examine the likelihood of nutritional vulnerability while exploring potential age and sex differences. Methods: This study employed a cross-sectional design through an online survey using the Qualtrics platform. Participants’ nutritional risk was assessed both before and after the onset of the COVID-19 pandemic (retrospectively) using the Dietary Screening Tool. This study involved a large sample of 10,050 participants aged between 40 and 100 years. The main outcome measures included changes in food consumption after the onset of the COVID-19 pandemic (from 9 August to 15 September 2020) and the likelihood of being classified as “nutritionally vulnerable” across different age and sex groups. Paired-samples t-tests were used to compare dietary changes before and after the onset of the COVID-19 pandemic, chi-square tests were used to explore categorical differences, and binary logistic regression was used to assess the likelihood of nutritional vulnerability. Results: The analysis revealed significant sex- and age-related differences in food consumption patterns after the onset of the pandemic. Men had a 30% greater likelihood of decreased dairy and processed meat consumption than women after the onset of the COVID-19 pandemic. Significant reductions in the consumption of processed meats (130%), vegetables (96%), lean protein (33%), and dairy (11%) were observed among individuals aged 40–60 years compared to those aged 81–100 years. The 61–80-year age group had a greater reduction in dairy consumption (21%) than the 81–100-year age group. Furthermore, women exhibited 17% greater odds of being classified as “nutritionally vulnerable” after the onset of the COVID-19 pandemic. However, age did not emerge as a significant predictor of nutritional vulnerability. Conclusions: The findings of this study can inform public health practitioners when developing interventions for improving dietary habits during and after pandemics, especially among vulnerable populations. Full article

Investigating how facial movements can be used to characterize and quantify speech is important, in particular, to aid those suffering from motor control speech disorders. Here, we sought to investigate how facial action units (AUs), previously used to classify human expressions and emotion, could be used to quantify and understand unimpaired human speech. Fourteen (14) adult participants (30.1 ± 7.9 years old), fluent in English, with no speech impairments, were examined. Within each data collection session, 6 video trials per participant per phoneme were acquired (i.e., 102 trials total/phoneme). The participants were asked to vocalize the vowels /æ/, /ɛ/, /ɪ/, /ɒ/, and /ʊ/; the consonants /b/, /n/, /m/, /p/, /h/, /w/, and /d/; and the diphthongs /eI/, /ʌɪ/, /i/, /a:/, and /u:/. Through the use of Python Py-Feat, our analysis displayed the AU contributions for each phoneme. The important implication of our methodological findings is that AUs could be used to quantify speech in populations with no speech disability; this has the potential to be broadened toward providing feedback and characterization of speech changes and improvements in impaired populations. This would be of interest to persons with speech disorders, speech language pathologists, engineers, and physicians. Full article

As precipitation analysis reveals critical statistical characteristics, temporal patterns, and spatial distributions of rainfall and snowfall events, it plays an important role in planning urban drainage systems, flood forecasting, hydrological modeling, and climate studies. It helps engineers design climate-resilient infrastructure capable of withstanding extreme weather events, which is becoming increasingly important as precipitation patterns change over time. With precipitation analysis, multiple valuable information can be determined, such as storm intensity, duration, and frequency. To enhance understanding of precipitation data and analysis results, researchers often use graphical representation methods to show the data in visual formats. Although existing precipitation analysis and basic visual representations are helpful, it is critical to have a comprehensive analysis and visualization system to detect significant patterns and anomalies in high-resolution temporal precipitation data more effectively. This study presents a visual analytics system enabling interactive analysis of hourly precipitation data across all U.S. states. Multiple coordinated visualizations are designed to support both single and multiple-station analysis. These visualizations allow users to examine temporal patterns, spatial distributions, and statistical characteristics of precipitation events directly within visualizations. Case studies demonstrate the usefulness of the designed system by evaluating various historical storm events. Full article

There have been significant breakthroughs in developing highly functional myoelectric prostheses, yet individuals who have experienced upper-limb loss consistently report low levels of satisfaction when performing daily tasks while using myoelectric prostheses. This research aims to evaluate the change in the user’s experience after completing a training program in which tasks are designed to facilitate adaptation to the myoelectric arm in performing the activities of daily living. One participant with a left transradial limb difference was recruited for this project. The user’s experience was evaluated by comparing task completion time, trunk and shoulder angles, object control, movement smoothness, vertical ground reaction forces, the center of pressure location, and selected muscle activation of her affected arm between baseline and post-training. The data collection was performed through a motion capture system, a pressure mat, and wireless EMG modules. While indications of potential improvements in balance, muscle efficiency, and functionality were present, the data were inconclusive as to the effectiveness of the training procedure. One outcome measure that showed improvement across most tasks was the task completion time, which, on average, for the targeted Box and Block Test (tBBT) task was reduced by 24.0 s, box lifting by 1.6 s, bottle pouring by 9.0 s, and the pulley task by 8.4 s. This project serves as part of a larger multi-visit study evaluating the effects of home-based functional training on facilitating users’ adaptation to the myoelectric arm. Full article