7,187 Results Found

The objective of this paper is to show how a completely virtual optimization approach is useful to design new geometries in order to improve the performance of industrial components, like valves. The standard approach for optimization of an industria...

This study aims to present the interest of using a design of experiments (DOE) approach for assessing, understanding and improving the hydride vapor phase epitaxy (HVPE) process, a particular class of chemical vapor deposition (CVD) process. The case...

The development of therapies to prevent or treat salivary gland dysfunction has been limited by a lack of functional in vitro models. Specifically, critical markers of salivary gland secretory phenotype downregulate rapidly ex vivo. Here, we utilize...

The aim of the present work was the development of a novel glycosaminoglycan (GAG)-based injectable formulation intended for intra-articular administration that should best mimic the healthy synovial fluid. Hyaluronic acid (HA) was chosen among GAG p...

Electrospinning bears great potential for the manufacturing of scaffolds for tissue engineering, consisting of a porous mesh of ultrafine fibers that effectively mimic the extracellular matrix (ECM) and aid in directing stem cell fate. However, for e...

Understanding the behavior of tires on uneven and varied road surfaces poses a substantial challenge for vehicle ride engineers. To accurately predict road load forces on the axle, various numerical ride models must be utilized to incorporate a reali...

The aim of the present work was the development of an innovative in situ gelling system, to be applied on the mucosa of the distal colon via rectal route. The system consisted of three polymers having different functions: gellan (GG), able to jellify...

The use of multifactorial design of experiments (DoE) in tissue engineering bioprocess development will contribute to the robust manufacturing of tissue engineered constructs by linking their quality characteristics to bioprocess operating parameters...

Liquid formulations have been successfully used in many viral vector vaccines including influenza (Flu), hepatitis B, polio (IPV), Ebola, and COVID-19 vaccines. The main advantage of liquid formulations over lyophilized formulations is that they are...

Ajowan (Trachyspermum ammi L.) is a spice traditionally used in Middle Eastern medicine and contains a valuable essential oil (EO) exploited in different fields, such as pharmaceutics, agrochemicals and food additives. This EO is mostly characterized...

Microfluidic liposome production presents a streamlined pathway for expediting the translation of liposomal formulations from the laboratory setting to clinical applications. Using this production method, resultant liposome characteristics can be tun...

In the present work, different hydrolases were adsorbed onto polypropylene beads to investigate their activity both in short-esters and polyesters synthesis. The software MODDE® Pro 13 (Sartorius) was used to develop a full-factorial design of experi...

Sand casting of lead sheet is a traditional manufacturing process used up to the present due to the special features of sand cast sheet such as their attractive sheen. Similarly to any casting process, sand casting of lead sheet suffers from the pres...

Marine origin polymers represent a sustainable and natural alternative to mammal counterparts regarding the biomedical application due to their similarities with proteins and polysaccharides present in extracellular matrix (ECM) in humans and can red...

A pediatric dosage form for crizotinib (Xalkori) was commercialized using quality-by-design principles in a material-sparing fashion. The dosage form consists of spherical multiparticulates (microspheres or pellets) that are coated and encapsulated i...

Tuberculosis (TB) is an airborne bacterial infection caused by Mycobacterium tuberculosis (M. tb), resulting in approximately 1.3 million deaths in 2022 worldwide. Oral therapy with anti-TB drugs often fails to achieve therapeutic concentrations at t...

The use of data-based models is a favorable way to optimize existing industrial processes. Estimation of these models requires data with sufficient information content. However, data from regular process operation are typically limited to single oper...

This paper is primarily concerned with determining and assessing the properties of a cement-based composite material containing large particles of aggregate in digital manufacturing. The motivation is that mixtures with larger aggregate sizes offer b...

This work employed a design-of-experiments (DoE) strategy, specifically a 23 full factorial design, to assess how suspension concentration (0.001–0.002 g/mL), substrate temperature (60–80 °C), and deposition height (10–15 cm) in...

The pursuit of environmentally friendly cutting fluids is ongoing as the problems of traditional cutting fluids become more apparent. The bulk of vegetable oils used in studies are consumable and, if marketed, may conflict with human utilization, mak...

Hydrogel microbeads hold great promise for immune-protective cell transplants and in vitro studies. Millifluidic generation of hydrogel microbeads is a highly efficient and reproducible approach enabling a mass production. This paper illustrates the...

Younger disabled adults in long-term care, particularly those with physical disabilities and chronic illnesses, receive care that does not fit their needs. This article looks at whether a Foucauldian genealogical approach would enhance a study that f...

Self-emulsifying drug delivery systems (SEDDS) consist of isotropic mixtures of oils, surfactants, and solvents that after dispersion emulsify in the aqueous media of the gastrointestinal tract (GIT). SEDDS can deliver hydrophobic drugs, which could...

What does it mean to truly empathize with a patient? The authors (a psychiatrist and a philosopher) explore this topic from the unique perspectives gained from decades of experience. We discuss how some approaches that may be criticized are necessary...

This study investigates the impact of human-like machines (HLMs) on the user experience (UX) of young adults during voice interactions between drivers and autonomous vehicles. A mixed-method approach was employed to evaluate three voice agents with v...

This study investigated whether manual integration in the recognition of the endothelial cells produces different outcomes of morphometric parameters compared to a fully automatic approach. Eight hundred and ninety endothelial images, originally acqu...

Research proposes that economic policy uncertainty (EPU) leads to exchange rate fluctuations. Given that African countries experience higher levels of uncertainty in developed/emerging markets, we examine the extent to which domestic and foreign EPU...

This commentary provides an update and clarification on the legislative landscape surrounding mulesing in Australia since the publication of the 2023 study, “How Well Does Australian Animal Welfare Policy Reflect Scientific Evidence: A Case Stu...

Chronic neck pain is one of today’s most prevalent pathologies. The International Classification of Diseases categorizes four subgroups based on patients’ associated symptoms. However, this classification does not encompass upper cervical...

This study aimed to examine the effect of a tennis training program on improving attention. Methods: A total of 40 tennis players from a Tennis Club, 20 in the experimental group (EG) and 20 in the control group (CG), participated in the study. The E...

This article presents a qualitative mathematical model to simulate the relationship between supplied water and plant growth. A novel aspect of the construction of this phenomenological model is the consideration of a structure of three phases: (1) Th...

Universally improving healthcare systems is difficult to achieve in practice with organisations implementing a range of quality improvement (QI) approaches, in varying and changing contexts, and efforts ranging from project-based improvements to whol...

All families deserve access to readily available, accurate, and relevant information to help them navigate the newborn screening system. Current practices, limited resources, and a siloed newborn screening system create numerous challenges for both p...

Aim: This study aimed to identify self-compassion among staff nurses after the COVID-19 pandemic in Qatar. Design: Descriptive cross-sectional survey design. Methods: Anonymous data were collected through an online survey using Microsoft Forms from 3...

Recent inconsistent empirical findings on the impact of context on foreign language development (FLD) are related to some conflicting context views, which hinders healthy FLD. Given this, an ecocontextualized approach/perspective is presented as a &r...

The purpose of this study is to investigate the value-relevance of corporate sustainability disclosure through integrated reporting. Sustainability disclosure is subject to managers’ discretion. Besides, it is often hardly verifiable. In this r...

The main objective of this study was to determine the influence of background noise levels and measurement approach on user-selected listening levels (USLLs) chosen by teenaged MP3 player users. It was hypothesized that the presence of background noi...

Graduate-entry, following a science degree, is the preferred pathway into many medical schools, however little is known about how the learning approaches of medical students compare to those of science students. This study compared the learning appro...

The main purpose of the current study is to investigate if tourism affects economic growth of China. The data set has been acquired from the Beijing Municipal Bureau of Statistics, and the time span of the data set takes into account a 20-year time p...

Flight departure delays cost airlines and airports millions of dollars and become a systematic problem. The on-time performance at an airport is connected to and easily affected by delay propagation from previous operations of flights using the airpo...

Aberrant DNA methylation, dysregulation of chromatin-modifying enzymes, and microRNAs (miRNAs) play a crucial role in haematological malignancies. These epimutations, with an impact on chromatin accessibility and transcriptional output, are often ass...

This editorial paper takes the form of a concise report and delves into a critical and intricate issue essential for the sustainability of agriculture. It centers on the intricate relationship between agri-cultural water resource management and agron...

In this study, we explore climate justice with specific reference to vulnerability at the level of different sectors in 90 developing countries in Asia, Africa and Europe, over a period from 2010 to 2019. The paper seeks to advance the discussion on...

This article focuses on the application of digital engineering in diffractive optics for precision laser material processing. It examines methods for the development of diffractive optical elements (DOEs) and adaptive management approaches that enhan...

The successful development of nonviral delivery systems for nucleic acids has been reported extensively over the past years. Increasingly employed to improve the delivery efficiency and therapeutic efficacy of RNA are lipid nanoparticles (LNPs). Many...

Parameter estimation is one of the most important tasks in statistics, and is key to helping people understand the distribution behind a sample of observations. Traditionally, parameter estimation is done either by closed-form solutions (e.g., maximu...

This review was devoted to outlining the use and potential increasing application of the Design of Experiment (DoE) approach to the rational and planned synthesis of inorganic nanomaterials, with a particular focus on polycrystalline nanostructures (...

This paper aims to introduce a mathematical-philosophical type of question from the fascinating world of generalized circle numbers to the widest possible readership. We start with recalling well-known (in part from school) properties of the polygona...

As the trend of aging in rural China has intensified, research on the factors affecting the health of the elderly in rural areas has become a hot issue. However, the conclusions of existing studies are inconsistent and even contradictory, making it d...

While the existence of mental illness has been documented for centuries, the understanding and treatment of such illnesses has evolved considerably over time. Ritual exorcisms and locking mentally ill patients in asylums have been fundamentally repla...