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148 Results Found

  • Article
  • Open Access
3 Citations
5,011 Views
20 Pages

31 January 2021

At host–pathogen contact sites with Candida albicans, Dectin-1 activates pro-inflammatory signaling, while DC-SIGN promotes adhesion to the fungal surface. We observed that Dectin-1 and DC-SIGN collaborate to enhance capture/retention of C. albicans...

  • Article
  • Open Access
6 Citations
2,889 Views
15 Pages

Human Milk Oligosaccharide 2′-Fucosyllactose Inhibits Ligand Binding to C-Type Lectin DC-SIGN but Not to Langerin

  • Reshmi Mukherjee,
  • Victor J. Somovilla,
  • Fabrizio Chiodo,
  • Sven Bruijns,
  • Roland J. Pieters,
  • Johan Garssen,
  • Yvette van Kooyk,
  • Aletta D. Kraneveld and
  • Jeroen van Bergenhenegouwen

25 November 2022

Human milk oligosaccharides (HMOs) and their most abundant component, 2′-Fucosyllactose (2′-FL), are known to be immunomodulatory. Previously, it was shown that HMOs and 2′-FL bind to the C-type lectin receptor DC-SIGN. Here we show...

  • Review
  • Open Access
2 Citations
4,979 Views
25 Pages

Development of Anti-Inflammatory Agents Utilizing DC-SIGN Mediated IL-10 Secretion in Autoimmune and Immune-Mediated Disorders: Bridging Veterinary and Human Health

  • Hayeon Baek,
  • Seung-Woo Yang,
  • Seulki Kim,
  • Yunseok Lee,
  • Hwi Park,
  • Min Park,
  • Byung-Ju Jeon,
  • Hanwool Park,
  • Han-Sung Hwang and
  • Young-Sun Kang
  • + 2 authors

DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) is a C-type lectin receptor expressed on dendritic cells and M2 macrophages, playing a key role in immune regulation and pathogen recognition. Its ability to me...

  • Article
  • Open Access
43 Citations
6,790 Views
17 Pages

Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates

  • J. Daniel Martínez,
  • Pablo Valverde,
  • Sandra Delgado,
  • Cecilia Romanò,
  • Bruno Linclau,
  • Niels C. Reichardt,
  • Stefan Oscarson,
  • Ana Ardá,
  • Jesús Jiménez-Barbero and
  • F. Javier Cañada

25 June 2019

A fluorine nuclear magnetic resonance (19F-NMR)-based method is employed to assess the binding preferences and interaction details of a library of synthetic fluorinated monosaccharides towards dendritic cell-specific intercellular adhesion molecule 3...

  • Article
  • Open Access
4 Citations
4,139 Views
16 Pages

Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study

  • Meina Gao,
  • Hui Li,
  • Chenghao Ye,
  • Kaixian Chen,
  • Hualiang Jiang and
  • Kunqian Yu

27 October 2021

Glycosylation is an important post-translational modification that affects a wide variety of physiological functions. DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a protein expressed in antigen-presenti...

  • Communication
  • Open Access
23 Citations
8,570 Views
13 Pages

Pseudo-Mannosylated DC-SIGN Ligands as Potential Adjuvants for HIV Vaccines

  • Angela Berzi,
  • Norbert Varga,
  • Sara Sattin,
  • Patrizio Antonazzo,
  • Mara Biasin,
  • Irene Cetin,
  • Daria Trabattoni,
  • Anna Bernardi and
  • Mario Clerici

27 January 2014

The development of new and effective adjuvants may play a fundamental role in improving HIV vaccine efficacy. New classes of vaccine adjuvants activate innate immunity receptors, notably toll like receptors (TLRs). Adjuvants targeting the C-Type lect...

  • Article
  • Open Access
23 Citations
5,813 Views
20 Pages

SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues

  • Guoshuai Cai,
  • Mulong Du,
  • Yohan Bossé,
  • Helmut Albrecht,
  • Fei Qin,
  • Xizhi Luo,
  • Xiao Michelle Androulakis,
  • Chao Cheng,
  • Mitzi Nagarkatti and
  • Feifei Xiao
  • + 4 authors

26 August 2021

The current spreading coronavirus SARS-CoV-2 is highly infectious and pathogenic. In this study, we screened the gene expression of three host receptors (ACE2, DC-SIGN and L-SIGN) of SARS coronaviruses and dendritic cells (DCs) status in bulk and sin...

  • Article
  • Open Access
1 Citations
3,481 Views
12 Pages

Glycan-Dependent and -Independent Dual Recognition between DC-SIGN and Type II Serine Protease MSPL/TMPRSS13 in Colorectal Cancer Cells

  • Motohiro Nonaka,
  • Shogo Matsumoto,
  • Bruce Yong Ma,
  • Hiroshi Kido,
  • Nana Kawasaki,
  • Nobuko Kawasaki and
  • Toshisuke Kawasaki

13 April 2020

A class of glycoproteins such as carcinoembryonic antigen (CEA)/CEA-related cell adhesion molecule 1(CEACAM1), CD26 (DPPIV), and mac-2 binding protein (Mac-2BP) harbor tumor-associated glycans in colorectal cancer. In this study, we identified type I...

  • Article
  • Open Access
30 Citations
9,744 Views
14 Pages

N-Glycans on the Rift Valley Fever Virus Envelope Glycoproteins Gn and Gc Redundantly Support Viral Infection via DC-SIGN

  • Inaia Phoenix,
  • Shoko Nishiyama,
  • Nandadeva Lokugamage,
  • Terence E. Hill,
  • Matthew B. Huante,
  • Olga A.L. Slack,
  • Victor H. Carpio,
  • Alexander N. Freiberg and
  • Tetsuro Ikegami

23 May 2016

Rift Valley fever is a mosquito-transmitted, zoonotic disease that infects humans and ruminants. Dendritic cell specific intercellular adhesion molecule 3 (ICAM-3) grabbing non-integrin (DC-SIGN) acts as a receptor for members of the phlebovirus genu...

  • Article
  • Open Access
5 Citations
3,400 Views
16 Pages

Suppression of DC-SIGN and gH Reveals Complex, Subset-Specific Mechanisms for KSHV Entry in Primary B Lymphocytes

  • Nancy Palmerin,
  • Farizeh Aalam,
  • Romina Nabiee,
  • Murali Muniraju,
  • Javier Gordon Ogembo and
  • Jennifer Totonchy

31 July 2021

Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of multiple cancers in immunocompromised patients including two lymphoproliferative disorders associated with KSHV infection of B lymphocytes. Despite many years of research into the...

  • Article
  • Open Access
5 Citations
2,931 Views
21 Pages

The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells

  • Laure Papin,
  • Martin Lehmann,
  • Justine Lagisquet,
  • Ghizlane Maarifi,
  • Véronique Robert-Hebmann,
  • Christophe Mariller,
  • Yann Guerardel,
  • Lucile Espert,
  • Volker Haucke and
  • Fabien P. Blanchet

Dendritic cells (DC) are critical cellular mediators of host immunity, notably by expressing a broad panel of pattern recognition receptors. One of those receptors, the C-type lectin receptor DC-SIGN, was previously reported as a regulator of endo/ly...

  • Article
  • Open Access
17 Citations
4,700 Views
22 Pages

Identification of Important N-Linked Glycosylation Sites in the Hemagglutinin Protein and Their Functional Impact on DC-SIGN Mediated Avian Influenza H5N1 Infection

  • Zih-Syuan Yang,
  • Szu-Wei Huang,
  • Wen-Hung Wang,
  • Chih-Yen Lin,
  • Chu-Feng Wang,
  • Aspiro Nayim Urbina,
  • Arunee Thitithanyanont,
  • Sung-Pin Tseng,
  • Po-Liang Lu and
  • Sheng-Fan Wang
  • + 1 author

DC-SIGN, a C-type lectin mainly expressed in dendritic cells (DCs), has been reported to mediate several viral infections. We previously reported that DC-SIGN mediated H5N1 influenza A virus (AIVs) infection, however, the important DC-SIGN interactio...

  • Article
  • Open Access
4 Citations
2,178 Views
17 Pages

C-type lectins in organisms play an important role in the process of innate immunity. In this study, a C-type lectin belonging to the DC-SIGN class of Micropterus salmoides was identified. MsDC-SIGN is classified as a type II transmembrane protein. T...

  • Review
  • Open Access
72 Citations
10,047 Views
15 Pages

22 December 2020

C-type lectin CD209/DC-SIGN and CD209L/L-SIGN proteins are distinct cell adhesion and pathogen recognition receptors that mediate cellular interactions and recognize a wide range of pathogens, including viruses such as SARS, SARS-CoV-2, bacteria, fun...

  • Article
  • Open Access
15 Citations
5,355 Views
18 Pages

The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

  • J. Daniel Martínez,
  • Angela S. Infantino,
  • Pablo Valverde,
  • Tammo Diercks,
  • Sandra Delgado,
  • Niels-Christian Reichardt,
  • Ana Ardá,
  • Francisco Javier Cañada,
  • Stefan Oscarson and
  • Jesús Jiménez-Barbero

4 August 2020

Fluorinated glycomimetics are frequently employed to study and eventually modulate protein–glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a co...

  • Article
  • Open Access
3 Citations
2,823 Views
15 Pages

Vaccination with DC-SIGN-Targeting αGC Liposomes Leads to Tumor Control, Irrespective of Suboptimally Activated T-Cells

  • Aram M. de Haas,
  • Dorian A. Stolk,
  • Sjoerd T. T. Schetters,
  • Laura Goossens-Kruijssen,
  • Eelco Keuning,
  • Martino Ambrosini,
  • Louis Boon,
  • Hakan Kalay,
  • Gert Storm and
  • Yvette van Kooyk
  • + 2 authors

Cancer vaccines have emerged as a potent strategy to improve cancer immunity, with or without the combination of checkpoint blockade. In our investigation, liposomal formulations containing synthetic long peptides and α-Galactosylceramide, alon...

  • Article
  • Open Access
1 Citations
2,289 Views
14 Pages

31 December 2023

Semen prostatic acid phosphatase (PAP) has been proposed as an endogenous ligand for dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), which plays a critical immuno-modulating role in maintaining homeostasis in the female reproductive tr...

  • Article
  • Open Access
66 Citations
7,076 Views
13 Pages

12 September 2017

Bovine lactoferrin (bLF) presents in milk and has been shown to inhibit several viral infections. Effective drugs are unavailable for the treatment of dengue virus (DENV) infection. In this study, we evaluated the antiviral effect of bLF against DENV...

  • Article
  • Open Access
4 Citations
4,470 Views
13 Pages

Objective: This study was conducted to identify the association between rs4804803 polymorphism in DC-SIGN with the susceptibility of severe dengue. Methods: A comprehensive search was conducted to identify all eligible papers in PubMed, Web of Scienc...

  • Article
  • Open Access
3 Citations
3,840 Views
34 Pages

18 December 2023

Although COVID-19 transmission has been reduced by the advent of vaccinations and a variety of rapid monitoring techniques, the SARS-CoV-2 virus itself has shown a remarkable ability to mutate and persist. With this long track record of immune escape...

  • Review
  • Open Access
50 Citations
11,373 Views
24 Pages

Flaviviruses are enveloped, positive single stranded ribonucleic acid (RNA) viruses with various routes of transmission. While the type and severity of symptoms caused by pathogenic flaviviruses vary from hemorrhagic fever to fetal abnormalities, the...

  • Article
  • Open Access
1 Citations
2,638 Views
17 Pages

Dendritic Cell Subpopulations Are Associated with Morphological Features of Breast Ductal Carcinoma In Situ

  • Joanna Szpor,
  • Joanna Streb,
  • Anna Glajcar,
  • Anna Streb-Smoleń,
  • Agnieszka Łazarczyk,
  • Paulina Korta,
  • Karolina Brzuszkiewicz,
  • Robert Jach and
  • Diana Hodorowicz-Zaniewska

Ductal carcinoma in situ (DCIS) is the preinvasive form of breast cancer (BC). It is disputed whether all cases of DCIS require extensive treatment as the overall risk of progression to BC is estimated at 40%. Therefore, the crucial objective for res...

  • Article
  • Open Access
8 Citations
3,775 Views
18 Pages

Transfection of Vitamin D3-Induced Tolerogenic Dendritic Cells for the Silencing of Potential Tolerogenic Genes. Identification of CSF1R-CSF1 Signaling as a Glycolytic Regulator

  • María José Mansilla,
  • Iñigo González-Larreategui,
  • Neus Figa-Martín,
  • Jaume Barallat,
  • Federico Fondelli,
  • Ares Sellés-Rius,
  • Bibiana Quirant-Sánchez,
  • Aina Teniente-Serra and
  • Eva Martínez-Cáceres

The use of autologous tolerogenic dendritic cells (tolDC) has become a promising strategy to re-establish immune tolerance in autoimmune diseases. Among the different strategies available, the use of vitamin D3 for the generation of tolDC (VitD3-tolD...

  • Article
  • Open Access
3 Citations
3,017 Views
20 Pages

18 January 2023

Treatment options for endometrial cancer (EC) do not provide satisfactory survival improvement for advanced cases, hence the interest in novel therapies utilizing immunological regulatory mechanisms. Measures to modify the functionality of dendritic...

  • Article
  • Open Access
5 Citations
4,631 Views
21 Pages

Generation of Liposomes to Study the Effect of Mycobacterium Tuberculosis Lipids on HIV-1 cis- and trans-Infections

  • Marion Pouget,
  • Anna K. Coussens,
  • Alessandra Ruggiero,
  • Anastasia Koch,
  • Jordan Thomas,
  • Gurdyal S. Besra,
  • Robert J. Wilkinson,
  • Apoorva Bhatt,
  • Georgios Pollakis and
  • William A. Paxton

16 February 2021

Tuberculosis (TB) is the leading cause of death among HIV-1-infected individuals and Mycobacterium tuberculosis (Mtb) co-infection is an early precipitate to AIDS. We aimed to determine whether Mtb strains differentially modulate cellular susceptibil...

  • Article
  • Open Access
2 Citations
2,783 Views
14 Pages

Fusion Proteins CLD and CLDmut Demonstrate Potent and Broad Neutralizing Activity against HIV-1

  • Ming Fu,
  • Yingying Xiao,
  • Tao Du,
  • Huimin Hu,
  • Fengfeng Ni,
  • Kai Hu and
  • Qinxue Hu

23 June 2022

HIV-1 envelope glycoprotein (Env) interacts with cellular receptors and mediates virus entry into target cells. Blocking Env-receptor interactions represents an effective interventional strategy for developing HIV-1 entry inhibitors. We previously de...

  • Article
  • Open Access
12 Citations
3,652 Views
17 Pages

Currently, there are no commercial vaccines or therapeutics against severe fever with thrombocytopenia syndrome (SFTS) virus. This study explored an engineered Salmonella as a vaccine carrier to deliver a eukaryotic self-mRNA replicating vector, pJHL...

  • Review
  • Open Access
33 Citations
7,657 Views
25 Pages

Glycan–Lectin Interactions in Cancer and Viral Infections and How to Disrupt Them

  • Stefanie Maria Kremsreiter,
  • Ann-Sophie Helene Kroell,
  • Katharina Weinberger and
  • Heike Boehm

30 September 2021

Glycan–lectin interactions play an essential role in different cellular processes. One of their main functions is involvement in the immune response to pathogens or inflammation. However, cancer cells and viruses have adapted to avail themselves of t...

  • Article
  • Open Access
13 Citations
2,911 Views
13 Pages

Topological and Multivalent Effects in Glycofullerene Oligomers as EBOLA Virus Inhibitors

  • Javier Ramos-Soriano,
  • Beatriz M. Illescas,
  • Alfonso Pérez-Sánchez,
  • Raquel Sánchez-Bento,
  • Fátima Lasala,
  • Javier Rojo,
  • Rafael Delgado and
  • Nazario Martín

The synthesis of new biocompatible antiviral materials to fight against the development of multidrug resistance is being widely explored. Due to their unique globular structure and excellent properties, [60]fullerene-based antivirals are very promisi...

  • Article
  • Open Access
7 Citations
3,019 Views
33 Pages

9 September 2023

The SARS-CoV-2 virion has shown remarkable resilience, capable of mutating to escape immune detection and re-establishing infectious capabilities despite new vaccine rollouts. Therefore, there is a critical need to identify relatively immutable epito...

  • Article
  • Open Access
13 Citations
5,003 Views
15 Pages

10 December 2022

Frequency-modulated continuous wave (FMCW) radars are currently being investigated for remote vital signs monitoring (measure of respiration and heart rates) as an innovative wireless solution for healthcare and ambient assisted living. However, stat...

  • Article
  • Open Access
1 Citations
3,461 Views
18 Pages

Dual Role of HIV-1 Envelope Signal Peptide in Immune Evasion

  • Chitra Upadhyay,
  • Priyanka Gadam Rao and
  • Roya Feyznezhad

13 April 2022

HIV-1 Env signal peptide (SP) is an important contributor to Env functions. Env is generated from Vpu/Env encoded bicistronic mRNA such that the 5′ end of Env-N-terminus, that encodes for Env-SP overlaps with 3′ end of Vpu. Env SP display...

  • Article
  • Open Access
7 Citations
2,745 Views
20 Pages

Dendritic Cell Subpopulations Are Associated with Prognostic Characteristics of Breast Cancer after Neoadjuvant Chemotherapy—An Observational Study

  • Agnieszka Łazarczyk,
  • Joanna Streb,
  • Anna Glajcar,
  • Anna Streb-Smoleń,
  • Przemysław Hałubiec,
  • Kacper Wcisło,
  • Łukasz Laskowicz,
  • Diana Hodorowicz-Zaniewska and
  • Joanna Szpor

31 October 2023

Breast cancer (BC) is the most prevalent malignancy in women and researchers have strived to develop optimal strategies for its diagnosis and management. Neoadjuvant chemotherapy (NAC), which reduces tumor size, risk of metastasis and patient mortali...

  • Article
  • Open Access
14 Citations
3,499 Views
15 Pages

Feasibility of Brewer’s Spent Yeast Microcapsules as Targeted Oral Carriers

  • Sofia F. Reis,
  • Vitor J. Martins,
  • Rita Bastos,
  • Tânia Lima,
  • Viviana G. Correia,
  • Benedita A. Pinheiro,
  • Lisete M. Silva,
  • Angelina S. Palma,
  • Paula Ferreira and
  • Elisabete Coelho
  • + 2 authors

5 January 2023

Brewer’s spent yeast (BSY) microcapsules have a complex network of cell-wall polysaccharides that are induced by brewing when compared to the baker’s yeast (Saccharomyces cerevisiae) microcapsules. These are rich in (β1→3)-gluca...

  • Review
  • Open Access
101 Citations
20,654 Views
43 Pages

Human Lectins and Their Roles in Viral Infections

  • Christopher P. Mason and
  • Alexander W. Tarr

29 January 2015

Innate recognition of virus proteins is an important component of the immune response to viral pathogens. A component of this immune recognition is the family of lectins; pattern recognition receptors (PRRs) that recognise viral pathogen-associated m...

  • Article
  • Open Access
7 Citations
4,603 Views
27 Pages

Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine (EFdA)-Suppressed Humanized Mice

  • Ekaterina Maidji,
  • Mary E. Moreno,
  • Jose M. Rivera,
  • Pheroze Joshi,
  • Sofiya A. Galkina,
  • Galina Kosikova,
  • Ma Somsouk and
  • Cheryl A. Stoddart

13 March 2019

Although antiretroviral therapy (ART) greatly suppresses HIV replication, lymphoid tissues remain a sanctuary site where the virus may replicate. Tracking the earliest steps of HIV spread from these cellular reservoirs after drug cessation is pivotal...

  • Review
  • Open Access
44 Citations
9,637 Views
23 Pages

Dendritic Cells and SARS-CoV-2 Infection: Still an Unclarified Connection

  • Pasquale Campana,
  • Valentina Parisi,
  • Dario Leosco,
  • Debora Bencivenga,
  • Fulvio Della Ragione and
  • Adriana Borriello

8 September 2020

The ongoing pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has so far infected about 2.42 × 107 (as at 27 August 2020) subjects with more than 820,000 deaths. It is the third zoonotic coronavirus-dependent outbreak...

  • Communication
  • Open Access
3 Citations
2,068 Views
11 Pages

28 August 2024

This paper presents a real-time and non-contact dual-mode embedded impulse-radio (IR) ultra-wideband (UWB) radar system designed for microwave imaging and vital sign applications. The system is fully customized and composed of three main components,...

  • Article
  • Open Access
20 Citations
5,030 Views
23 Pages

Dynamic Digital Signal Processing Algorithm for Vital Signs Extraction in Continuous-Wave Radars

  • Carolina Gouveia,
  • Daniel Albuquerque,
  • José Vieira and
  • Pedro Pinho

13 October 2021

Radar systems have been widely explored as a monitoring tool able to assess the subject’s vital signs remotely. However, their implementation in real application scenarios is not straightforward. Received signals encompass parasitic reflections that...

  • Article
  • Open Access
5 Citations
2,788 Views
15 Pages

Presence of Dendritic Cell Subsets in Sentinel Nodes of Breast Cancer Patients Is Related to Nodal Burden

  • Joanna Szpor,
  • Joanna Streb,
  • Anna Glajcar,
  • Piotr Sadowski,
  • Anna Streb-Smoleń,
  • Robert Jach and
  • Diana Hodorowicz-Zaniewska

BACKGROUND: Sentinel lymph nodes (SLNs) are both the first site where breast cancer (BC) metastases form and where anti-tumoral immunity develops. Despite being the most potent antigen-presenting cells, dendritic cells (DCs) located in a nodal tissue...

  • Article
  • Open Access
70 Citations
6,871 Views
18 Pages

Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination

  • Sophie K. Horrevorts,
  • Dorian A. Stolk,
  • Rieneke van de Ven,
  • Myrthe Hulst,
  • Bert van Het Hof,
  • Sanne Duinkerken,
  • Marieke H. Heineke,
  • Wenbin Ma,
  • Sophie A. Dusoswa and
  • Yvette van Kooyk
  • + 5 authors

28 August 2019

Tumors that lack T cell infiltration are less likely to respond to immune checkpoint inhibition and could benefit from cancer vaccination for the initiation of anti-tumor T cell responses. An attractive vaccine strategy is in vivo targeting of dendri...

  • Article
  • Open Access
10 Citations
4,958 Views
20 Pages

ICAM3-Fc Outperforms Receptor-Specific Antibodies Targeted Nanoparticles to Dendritic Cells for Cross-Presentation

  • Luis J. Cruz,
  • Paul J. Tacken,
  • Johan M.S. van der Schoot,
  • Felix Rueda,
  • Ruurd Torensma and
  • Carl G. Figdor

Optimal targeting of nanoparticles (NP) to dendritic cells (DCs) receptors to deliver cancer-specific antigens is key to the efficient induction of anti-tumour immune responses. Poly (lactic-co-glycolic acid) (PLGA) nanoparticles containing tè...

  • Review
  • Open Access
5 Citations
3,069 Views
19 Pages

Environmental pollution, chronic stress, and unhealthy lifestyle are factors that negatively affect reproductive potential. Currently, 15–20% of couples in industrialized countries face the problem of infertility. This growing health and social...

  • Article
  • Open Access
56 Citations
8,127 Views
19 Pages

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice

  • Maciej Lech,
  • Heni Eka Susanti,
  • Christoph Römmele,
  • Regina Gröbmayr,
  • Roman Günthner and
  • Hans-Joachim Anders

14 August 2012

C-type lectin receptors and their adaptor molecules are involved in the recognition of glycosylated self-antigens and pathogens. However, little is known about the species- and organ-specific expression profiles of these molecules. We therefore deter...

  • Article
  • Open Access
2 Citations
3,128 Views
13 Pages

Urine of Cats with Severe Fever with Thrombocytopenia Syndrome: A Potential Source of Infection Transmission

  • Hirohisa Mekata,
  • Mari Yamamoto,
  • Yasuyuki Kaneko,
  • Kentaro Yamada,
  • Tamaki Okabayashi and
  • Akatsuki Saito

Severe fever with thrombocytopenia syndrome (SFTS), caused by infection with the SFTS virus, is an emerging fatal tick-borne zoonosis endemic to East Asia. Although SFTS is a tick-borne disease, the virus can be transmitted from animals with SFTS wit...

  • Article
  • Open Access
2 Citations
1,222 Views
16 Pages

Background: Nodal dendritic cells (DCs) and CD169-positive macrophages, possibly monocyte-derived, cross-present cancer antigens earlier in the proximal node than in the distal node. Methods: We performed immunohistochemical and morphometric analyses...

  • Article
  • Open Access
41 Citations
4,031 Views
17 Pages

Dendritic Cells Are Associated with Prognosis and Survival in Breast Cancer

  • Joanna Szpor,
  • Joanna Streb,
  • Anna Glajcar,
  • Paulina Frączek,
  • Aleksandra Winiarska,
  • Katarzyna E. Tyrak,
  • Paweł Basta,
  • Krzysztof Okoń,
  • Robert Jach and
  • Diana Hodorowicz-Zaniewska

Dendritic cells (DCs) constitute a part of the tumour microenvironment, but we are still far from understanding their complex role in immune response to the tumour. This study aimed to investigate the density of DCs expressing CD1a, CD83, CD123, DC-L...

  • Article
  • Open Access
1 Citations
1,572 Views
20 Pages

Polyvalent Mannuronic Acid-Coated Gold Nanoparticles for Probing Multivalent Lectin–Glycan Interaction and Blocking Virus Infection

  • Rahman Basaran,
  • Darshita Budhadev,
  • Eleni Dimitriou,
  • Hannah S. Wootton,
  • Gavin J. Miller,
  • Amy Kempf,
  • Inga Nehlmeier,
  • Stefan Pöhlmann,
  • Yuan Guo and
  • Dejian Zhou

30 July 2025

Multivalent lectin–glycan interactions (MLGIs) are vital for viral infection, cell-cell communication and regulation of immune responses. Their structural and biophysical data are thus important, not only for providing insights into their under...

  • Communication
  • Open Access
7 Citations
3,554 Views
15 Pages

Vector and Host C-Type Lectin Receptor (CLR)–Fc Fusion Proteins as a Cross-Species Comparative Approach to Screen for CLR–Rift Valley Fever Virus Interactions

  • Kathleen Schön,
  • Dimitri L. Lindenwald,
  • João T. Monteiro,
  • Julien Glanz,
  • Klaus Jung,
  • Stefanie C. Becker and
  • Bernd Lepenies

Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus endemic to Africa and the Arabian Peninsula, which causes diseases in humans and livestock. C-type lectin receptors (CLRs) represent a superfamily of pattern recognition receptors that wer...

  • Article
  • Open Access
17 Citations
4,650 Views
16 Pages

26 November 2021

The O-GlcNAcylation is a posttranslational modification of proteins regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase. These enzymes regulate the development, proliferation and function of cells, including the immune cells. Herein, we focused o...

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