Search Results (13)

Background: Genetic insights from diverse populations are key to advancing cancer detection, treatment, and prevention. Unlike other Latin American countries, Colombia lacks a centralized registry for germline and somatic mutations in breast and ovarian cancer. This study describes the country’s first national variant registry, and the occurrence of recurrent mutations and potential founder effects in Colombia. Methods: To address this gap, we implemented the first capturing protocol using the REDCap system. In a group of 213 breast and/or ovarian cancer patients harboring genetic mutations, we collected genetic, clinical, and demographic data from 13 regional centers across Colombia. Statistical analyses assessed variant distribution and patient demographics. Results: Among 229 identified variants (105 germline, 124 somatic), most were classified as pathogenic or likely pathogenic (72.4% germline, 87% somatic). BRCA1 and BRCA2 accounted for the majority of recurrent mutations. Germline recurrent variants (seen >3 times) were recorded for BRCA1 (77.7%; 21/27) and BRCA2 (22.3%; 6/27). Similarly, recurrent somatic variants were identified for BRCA1 (82.6%; 38/46) and BRCA2 (17.4%; 8/46). Notably, four recurrent variants were previously reported as founder mutations: BRCA1 c.1674del (14.3% germline and 23.7% somatic), BRCA1 c.3331_3334del (33.3% germline and 52.6% somatic), BRCA1 c.5123C>A (52.4% germline and 23.7% somatic), and BRCA2 c.2808_2811del (50% germline and 50% somatic). Most cases originated from the Andean region, highlighting regional disparities. Conclusions: This registry offers the first overview of genetic variants in Colombian breast and ovarian cancer patients. Recurrent and region-specific mutations highlight the need for population-focused data to guide targeted screening and personalized care strategies. Full article

White-lipped peccary (Tayassu pecari) and Central American tapir (Tapirus bairdii) are two endangered ungulates that inhabit the Maya Forest in Southern Mexico. These species need water sources almost every day to fill their ecological and physiological needs. How have they survived in a landscape like the Calakmul Biosphere Reserve where the water is very scarce and temporal? We analyzed 10 years of data for both species, collected through the intensive use of camera traps located in 18 ephemeral ponds of the Mexican side of the Maya Forest. These data in combination with occasional data on individual movements of both species collected with radiotelemetry allowed us to describe changes in occupancy, abundance, and movements that show the different strategies these species must cope with during dry periods. The white-lipped peccary population passed through cycles and disappeared from periods of water scarcity, and later, they appeared and stayed close to a few sources of water while the tapir population remained constant and occupied almost all sources of water throughout the years. This contribution increases the ecological knowledge and survival strategies of two endangered tropical ungulates of Mesoamerican Forests that have been disappearing at alarming rates in other forests of the region. Full article

Glioblastoma (GBM) is the most aggressive and heterogeneous neoplasm among central nervous system tumors, with a dismal prognosis and a high recurrence rate. Among the various genetic alterations found in GBM, the amplification of epidermal growth factor receptor (EGFR) and the EGFR variant III (EGFRvIII) mutation are among the most common, though their prognostic value remains controversial. This systematic review and meta-analysis aimed to provide a comprehensive evaluation of the diagnostic and prognostic significance of EGFR amplification and the EGFRvIII mutation in GBM patients, incorporating recent studies published in the past few years to offer a more complete and up-to-date analysis. An extensive search of the PubMed, Web of Science, and Scopus databases was conducted, including studies that reported on EGFR and/or the EGFRvIII mutation status with detailed survival data. A total of 32 studies with 4208 GBM patients were included. The results indicated that EGFR amplification significantly correlated with worse OS (Overall survival) (HR = 1.27, 95% CI: 1.03–1.57), suggesting that EGFR amplification is an independent prognostic marker. The prognostic value of EGFRvIII was inconclusive, with a pooled hazard ratio for overall survival of 1.13 (95% CI: 0.94–1.36), indicating no significant effect on survival in the general population. However, a subgroup analysis suggested that EGFRvIII may be associated with poorer outcomes, particularly in recurrent GBM patients, where its prognostic significance became more evident. Furthermore, subgroup analyses based on geographic region revealed significant heterogeneity in the prognostic impact of EGFR amplification across different populations. In American cohorts, EGFR amplification was strongly associated with an increased risk of mortality (HR = 1.53, 95% CI: 1.28–1.84, p = 0.001), suggesting that it serves as a more reliable prognostic marker in this region. In contrast, no significant prognostic impact of EGFR amplification was observed in Asian (HR = 0.64, 95% CI: 0.35–1.17) or European (HR = 0.98, 95% CI: 0.80–1.19) populations. Overall, this study underscores the potential of EGFR amplification as a prognostic marker in GBM, while further research is needed to fully elucidate the role of the EGFRvIII mutation, particularly in specific patient subgroups. Clarifying these associations could offer important insights for targeted treatment strategies, improving patient outcomes. Full article

This paper analyzes the development and consolidation of anticommunist discourse in the General Conferences of the Latin American Episcopate (CELAM), from Rio de Janeiro to Aparecida. It adopts a critical perspective to examine the construction of the “messianic fraternity” myth—an ideological narrative contrasting Christian ideals of community and redemption with Marxist principles of class struggle and revolution, which served as a central axis for the Church’s rejection of communism in Latin America. Grounded in a critical analysis of the CELAM’s final documents, this study identifies the theological, political, and social underpinnings of this stance, situating it within the historical and geopolitical dynamics that positioned the Church as a key counterforce to Marxism in the region. It also examines how anticommunist positions shaped pastoral strategies, particularly in relation to social movements like liberation theology, and reinforced an episcopal identity centered on defending Christian values against a perceived global ideological threat. This analysis highlights the Church’s internal tensions and contradictions and the broader impact of its anticommunist stance on Latin America’s sociopolitical and religious dynamics in the twentieth century. Full article

The analysis of deformation dynamics in Guatemala city and its surrounding region presented in this paper holds significant relevance due to the high vulnerability of this area to natural disasters, combined with its rapid urbanization, similar to most Central American cities, contrasting with a lack of InSAR and deformation studies in the region. A total of 226 SAR images from Sentinel-1 A and B satellites in both ascending and descending geometries were processed with the Persistent Scatterer Interferometry (PSI) technique employing the SNAP-StaMPS integrated processing chain. The study area encompasses the Metropolitan Region of Guatemala, which is characterized by a diverse and active geological framework, with a historical record of earthquakes, intense groundwater extraction, and local subsidence phenomena, causing fissures and sinkholes. Four active areas were identified in the study area, each covering more than 50 hectares, with subsidence velocities greater than 10 mm/yr. This study provides valuable insights into fostering the sustainable development of this region by identifying deformation patterns, characterizing main active areas, and evaluating associated risks for disaster management and prevention. The results can also aid informed decision-making processes and guide urban planning and resource management strategies in other Central American countries. The application of InSAR studies is crucial for improving safety and sustainability in urban environments and natural resource management in vulnerable regions. Full article

The COVID-19 pandemic has recently caused the loss of millions of lives, and billions of others have been deeply affected. This crisis has changed the way people live, think about life, and perceive happiness. The aim of this study is to reveal differences between geographical regions by investigating the effect of the happiness variable on different countries during the international COVID-19 pandemic. The primary purpose is to demonstrate how such a pandemic may affect different countries in terms of happiness at the individual level and to identify possible strategies for the future. With this aim, both static and dynamic panel data models were used while applying fixed effects, random effects, and the generalized method of moments (GMM). A basic assumption in panel data models is that the coefficients do not change over time. This assumption is unlikely to hold, however, especially during major devastating events like COVID-19. Therefore, the piecewise linear panel data model was applied in this study. As a result of empirical analysis, pre- and post-COVID differences were seen between different geographical regions. Based on analysis conducted for three distinct geographical regions with piecewise linear models, it was determined that the piecewise random effects model was appropriate for European and Central Asian countries, the piecewise FGLS model for Latin American and Caribbean countries, and the piecewise linear GMM model for South Asian countries. According to the results, there are many variables that affect happiness, which vary according to different geographical conditions and societies with different cultural values. Full article

Mahogany (Swietenia macrophylla King) is a species with great economic interest worldwide and is classified as vulnerable to extinction by the IUCN. Deforestation and climate change are the main hazards to this species. Therefore, it is vital to describe possible changes in distribution patterns under current and future climatic conditions, as they are important for their monitoring, conservation, and use. In the current study, we predict, for the very first time, the potential distribution of Mahogany based on data that reflect the total distribution of the species, climatic and edaphic variables, and a consensus model that combines the results of three statistical techniques. The obtained model was projected to future climatic conditions considering two general circulation models (GCM), under two shared socioeconomic pathways (SSP245 and SSP585) for 2070. Predictions under current climatic conditions indicated wide adequate areas in Central American countries such as Mexico and demonstrated a coverage of up to 28.5% within the limits of the protected areas. Under future scenarios, drastic reductions were observed in different regions, particularly in Venezuela, Perú, and Ecuador, with losses of up to 56.0%. On the other hand, an increase in suitable areas for the species within protected areas was also detected. The results of this study are certainly useful for identifying currently unrecorded populations of Mahogany, as well as for identifying locations that are likely to be suitable both now and in the future for conservation management planning. The methodology proposed in this work is able to be used for other forest species in tropical zones as a tool for conducting dynamic conservation and restoration strategies that consider the effects of climate change. Full article

Within Neotropical pit-vipers, the Mexican/Central-American clade consisting of Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium is a wide-ranging, morphologically and ecologically diverse group of snakes. Despite their prevalence, little is known of the functional aspects of their venoms. This study aimed to fill the knowledge gap regarding coagulotoxic effects and to examine the potential of different therapeutic approaches. As a general trait, the venoms were shown to be anticoagulant but were underpinned by diverse biochemical actions. Pseudo-procoagulant activity (i.e., thrombin-like), characterized by the direct cleavage of fibrinogen to form weak fibrin clots, was evident for Atropoides picadoi, Cerrophidiontzotzilorum, Metlapilcoatlus mexicanus, M. nummifer, M. occiduus, M. olmec, and Porthidium porrasi. In contrast, other venoms cleaved fibrinogen in a destructive (non-clotting) manner, with C. godmani and C. wilsoni being the most potent. In addition to actions on fibrinogen, clotting enzymes were also inhibited. FXa was only weakly inhibited by most species, but Cerrophidion godmani and C. wilsoni were extremely strong in their inhibitory action. Other clotting enzymes were more widely inhibited by diverse species spanning the full taxonomical range, but in each case, there were species that had these traits notably amplified relatively to the others. C. godmani and C. wilsoni were the most potent amongst those that inhibited the formation of the prothrombinase complex and were also amongst the most potent inhibitors of Factor XIa. While most species displayed only low levels of thrombin inhibition, Porthidium dunni potently inhibited this clotting factor. The regional polyvalent antivenom produced by Instituto Picado Clodomiro was tested and was shown to be effective against the diverse anticoagulant pathophysiological effects. In contrast to the anticoagulant activities of the other species, Porthidium volcanicum was uniquely procoagulant through the activation of Factor VII and Factor XII. This viperid species is the first snake outside of the Oxyuranus/Pseudonaja elapid snake clade to be shown to activate FVII and the first snake venom of any kind to activate FXII. Interestingly, while small-molecule metalloprotease inhibitors prinomastat and marimastat demonstrated the ability to prevent the procoagulant toxicity of P. volcanicum, neither ICP antivenom nor inhibitor DMPS showed this effect. The extreme variation among the snakes here studied underscores how venom is a dynamic trait and how this can shape clinical outcomes and influence evolving treatment strategies. Full article

Worldwide, organic waste represents one of the most significant shares in the waste management system. Within the framework of circular bioeconomy, new and cutting-edge infrastructure has been developed at the European level to turn organic waste into valuable resources. The present paper aims to provide an exhaustive comparison between the European Union and Latin America regarding organic waste valorization. To this end, an introductive analysis about the state of the art circular bioeconomy in Latin America and Caribbean countries was developed. Subsequently, a systematic literature review in the context of South and Central America was conducted to detect differences and similarities in technologies and best practices for treating biowaste. The results show that the Latin American region is home to numerous bio-based infrastructures: biogas recovery, composting facilities and bioremediation strategies. Nevertheless, a conclusive remark underlines that some social, economic and political barriers are still encountered in the region, and therefore, new and locally-based studies are of paramount importance. Full article

Organizations need to develop their resilience to foster future success to survive complex environments. This research conducts a comparative analysis to understand firms’ strategies in a “black swan” event. We use the “strategy tripod” to operationalize resilience theory and explain the configurations or pathways that lead to high organizational resilience in a crisis context. The data correspond to 1936 firms drawn from the “Enterprise Survey 2020 for Innovation and Entrepreneurship in China (ESIEC)”, and to 66 Central American firms drawn from the “World Bank 2020 Enterprise Surveys” are also analyzed. The methodological approach fuzzy set qualitative comparative analysis (fsQCA) is applied. We discuss and analyze the strategies of companies in this “new normal”; our results establish that in the case of emerging economies, organizational innovation seems to be a necessary condition for becoming an organizational resilience to a black swan crisis (finding from both cases). We also found that labor flexibility and emotional intelligence for the case of firms from China, and adequate control of the turbulence environment for the cases of Central America, were also necessary conditions for each region. We further argue that digitalization depends on access to government support for its success. China reinforces its strategies in an intensification of human resources flexibility. In addition, they are better prepared for the “black swan” crisis, allowing them to adapt quickly and generate business model innovation to mitigate the effects of the pandemic in this “new normal.” In contrast, Central America needs rapid organization for organizational resilience. Full article

According to data from the U.S. National Cancer Institute, cancer is one of the leading causes of death worldwide with approximately 14 million new cases and 8.2 million cancer-related deaths in 2018. More than 60% of the new annual cases in the world occur in Africa, Asia, Central America, and South America, with 70% of cancer deaths in these regions. Breast cancer is the most common cancer in women, with 266,120 new cases in American women and an estimated 40,920 deaths for 2018. Approximately one in six women diagnosed with breast cancer will die in the coming years. Recently, novel therapeutic strategies have been implemented in the fight against breast cancer, including molecules able to block signaling pathways, an inhibitor of poly [ADP-ribose] polymerase (PARP), growth receptor blocker antibodies, or those that reactivate the immune system by inhibiting the activities of inhibitory receptors like cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death protein 1 (PD-1). However, novel targets include reactivating the Th1 immune response, changing tumor microenvironment, and co-activation of other components of the immune response such as natural killer cells and CD8+ T cells among others. In this article, we review advances in the treatment of breast cancer focused essentially on immunomodulatory drugs in targeted cancer therapy. Based on this knowledge, we formulate a proposal for the implementation of combined therapy using an extracorporeal immune response reactivation model and cytokines plus modulating antibodies for co-activation of the Th1- and natural killer cell (NK)-dependent immune response, either in situ or through autologous cell therapy. The implementation of “combination immunotherapy” is new hope in breast cancer treatment. Therefore, we consider the coordinated activation of each cell of the immune response that would probably produce better outcomes. Although more research is required, the results recently achieved by combination therapy suggest that for most, if not all, cancer patients, this tailored therapy may become a realistic approach in the near future. Full article

A country’s ability to prepare for, detect, and respond to infectious disease outbreaks such as the Ebola outbreaks in West Africa and the Democratic Republic of the Congo, and the recent Zika outbreak in the Latin American and Caribbean region, depends greatly on its competency in mobilizing skilled staff, and in providing and resupplying its health system with essential infection prevention and control commodities during public health emergencies. Health systems in most developing countries suffer from fragmentation; limited coordination and leadership; lack of national health security policies and legislation; low staff capacity and competency; and inadequate information systems necessary for decision making. The global health security agenda (GHSA) has stepped up efforts to build the capacity of such countries to effectively respond to health emergencies by strengthening health systems preparedness and ability to respond to outbreaks and epidemics. Chemonics International leads the implementation of multiple efforts to strengthen health systems across the world in support of the GHSA mission, both through the implementation of USAID funded activities and through its membership in the GHSA Private Sector Roundtable. Under the USAID Global Health Supply Chain—Technical Assistance Francophone Task Order, Chemonics developed a framework of essential competencies for emergency supply chain (ESC) management to help countries prepare and respond to outbreaks and epidemics. This framework has been piloted in Cameroon, and has wide-ranging applications for ministries of health, central medical stores, and regional level logistics units. Additionally, Chemonics, through the USAID funded Human Resources for Health in 2030 (HRH2030) program, supports the efforts of National One Health Platforms to ensure efficient multisectoral coordination; support integrated surveillance, preparedness, and response systems; and develop emerging diseases preparedness and response plans as well as prevention and control strategies, including leading the first ever simulation exercise in Ethiopia focused on Highly Pathogenic Avian Influenza. Full article

Outbreaks of the southern pine beetle (SPB) Dendroctonus frontalis Zimmermann in Central America have had a devastating impact on pine forests. It remains unclear to what extent these outbreaks are caused by the beetle’s ecology, climate, and historical management practices. Using research data and experience accumulated in northern latitudes to guide management of forests in Central America is associated with great uncertainty, given the many unique features of the conifer forests in this region. The main recommendation from this review is that Central American bark beetle outbreaks need to be studied locally, and the local climate, biotic elements, and silvicultural history need to be considered. The key to reducing the impacts of SPB in Central America are local research and implementation of proactive management, in order to facilitate the establishment of forests more resilient to increasing environmental and anthropogenic pressures. Full article