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25 Results Found

  • Article
  • Open Access
116 Citations
15,966 Views
18 Pages

17 September 2019

Seaweeds are gaining a considerable amount of attention for their antioxidant and antibacterial properties. Caulerpa racemosa and Caulerpa lentillifera, also known as ‘sea grapes’, are green seaweeds commonly found in different parts of t...

  • Article
  • Open Access
584 Views
16 Pages

Integrative Metabolomics, Pharmacoinformatics and Experimental Studies Reveal the Neuroprotective Potential of Caulerpa racemosa Metabolites Against Alzheimer’s Disease

  • Nita Handayani,
  • Dhecella Winy Cintya Ningrum,
  • Adha Fauzi Hendrawan,
  • Anis Yuniati,
  • Raffaele Romano,
  • Lucia De Luca,
  • Antonello Santini and
  • Fahrul Nurkolis

11 December 2025

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by cholinergic dysfunction, oxidative/nitrosative stress, and neuroinflammation. Marine green algae Caulerpa racemosa are rich in neuroactive lipids and fatty...

  • Article
  • Open Access
59 Citations
7,210 Views
20 Pages

Bioprospecting Cultivated Tropical Green Algae, Caulerpa racemosa (Forsskal) J. Agardh: A Perspective on Nutritional Properties, Antioxidative Capacity and Anti-Diabetic Potential

  • Abdul Qudus B Aroyehun,
  • Shariza Abdul Razak,
  • Kishneth Palaniveloo,
  • Thilahgavani Nagappan,
  • Nur Suraiza Nabila Rahmah,
  • Gan Wee Jin,
  • Dinesh Kumar Chellappan,
  • Jestin Chellian and
  • Anil Philip Kunnath

18 September 2020

Caulerpa racemosa (Forsskal) J. Agardh is a green seaweed used as food and folk medicine since ancient times in the Indo-Pacific region, particularly in southeast Asia. In this study, the proximate nutrient composition, phytochemical, anti-oxidant an...

  • Article
  • Open Access
62 Citations
6,408 Views
17 Pages

15 October 2021

Caulerpa racemosa (sea grapes) and Ulva lactuca (sea lettuces) are edible green seaweeds and good sources of bioactive compounds for future foods, nutraceuticals and cosmeceutical industries. In the present study, we determined nutritional values and...

  • Article
  • Open Access
33 Citations
5,765 Views
19 Pages

Dietary Supplementation of Caulerpa racemosa Ameliorates Cardiometabolic Syndrome via Regulation of PRMT-1/DDAH/ADMA Pathway and Gut Microbiome in Mice

  • Fahrul Nurkolis,
  • Nurpudji Astuti Taslim,
  • Dionysius Subali,
  • Rudy Kurniawan,
  • Hardinsyah Hardinsyah,
  • William Ben Gunawan,
  • Rio Jati Kusuma,
  • Vincentius Mario Yusuf,
  • Adriyan Pramono and
  • Bonglee Kim
  • + 5 authors

11 February 2023

This study evaluated the effects of an aqueous extract of Caulerpa racemosa (AEC) on cardiometabolic syndrome markers, and the modulation of the gut microbiome in mice administered a cholesterol- and fat-enriched diet (CFED). Four groups of mice rece...

  • Article
  • Open Access
13 Citations
3,494 Views
16 Pages

Sulfated Polysaccharide from Caulerpa racemosa Attenuates the Obesity-Induced Cardiometabolic Syndrome via Regulating the PRMT1-DDAH-ADMA with mTOR-SIRT1-AMPK Pathways and Gut Microbiota Modulation

  • Nelly Mayulu,
  • William Ben Gunawan,
  • Moon Nyeo Park,
  • Sanghyun Chung,
  • Jin Young Suh,
  • Hangyul Song,
  • Rio Jati Kusuma,
  • Nurpudji Astuti Taslim,
  • Rudy Kurniawan and
  • Bonglee Kim
  • + 2 authors

3 August 2023

Our investigation intended to analyze the effects of sulfated polysaccharides from Caulerpa racemosa (SPCr) in attenuating obesity-induced cardiometabolic syndrome via regulating the protein arginine N-methyltransferase 1-asymmetric dimethylarginine-...

  • Article
  • Open Access
4 Citations
2,816 Views
13 Pages

Photosynthetic, Molecular and Ultrastructural Characterization of Toxic Effects of Zinc in Caulerpa racemosa Indicate Promising Bioremediation Potentiality

  • Simone Landi,
  • Giorgia Santini,
  • Ermenegilda Vitale,
  • Gabriella Di Natale,
  • Giulia Maisto,
  • Carmen Arena and
  • Sergio Esposito

27 October 2022

Caulerpaceae are unconventional green algae composed of multinucleated, single siphonous cells. The species of Caulerpa are acquiring major scientific interest for both their invasion in the Mediterranean ecological niche and for the production of va...

  • Article
  • Open Access
1 Citations
2,253 Views
27 Pages

Sea Grape (Caulerpa racemosa) Kombucha: A Comprehensive Study of Metagenomic and Metabolomic Profiling, Its Molecular Mechanism of Action as an Antioxidative Agent, and the Impact of Fermentation Time

  • Dian Aruni Kumalawati,
  • Reza Sukma Dewi,
  • Noor Rezky Fitriani,
  • Scheirana Zahira Muchtar,
  • Juan Leonardo,
  • Nurpudji Astuti Taslim,
  • Raffaele Romano,
  • Antonello Santini and
  • Fahrul Nurkolis

5 September 2025

Sea grape kombucha has been known to exhibit high antioxidant activity due to its elevated total polyphenol content. This study aims to identify and characterize the active microbial community involved in the fermentation of kombucha using sea grapes...

  • Article
  • Open Access
59 Citations
8,083 Views
23 Pages

An Analysis of the Nutritional and Health Values of Caulerpa racemosa (Forsskål) and Ulva fasciata (Delile)—Two Chlorophyta Collected from the Philippines

  • Rexie P. Magdugo,
  • Nolwenn Terme,
  • Marie Lang,
  • Hugo Pliego-Cortés,
  • Christel Marty,
  • Anicia Q. Hurtado,
  • Gilles Bedoux and
  • Nathalie Bourgougnon

24 June 2020

Polysaccharides, lipids and amino acid profiles were investigated to understand the nutritional value of Caulerpa racemosa and Ulva fasciata from the Philippines. The results revealed that both species contain high amounts of proteins (8.8–19.9...

  • Article
  • Open Access
75 Citations
7,806 Views
15 Pages

Carotenoids Composition of Green Algae Caulerpa racemosa and Their Antidiabetic, Anti-Obesity, Antioxidant, and Anti-Inflammatory Properties

  • Rudy Kurniawan,
  • Fahrul Nurkolis,
  • Nurpudji Astuti Taslim,
  • Dionysius Subali,
  • Reggie Surya,
  • William Ben Gunawan,
  • Darmawan Alisaputra,
  • Nelly Mayulu,
  • Netty Salindeho and
  • Bonglee Kim

Green alga Caulerpa racemosa is an underexploited species of macroalgae, even though it is characterized by a green color that indicates an abundance of bioactive pigments, such as chlorophyll and possibly xanthophyll. Unlike chlorophyll, which has b...

  • Article
  • Open Access
45 Citations
9,010 Views
23 Pages

28 April 2023

Exploration of seaweeds to unravel their bioactive metabolites from the perspective of wider applications gained substantial importance. The present study was performed to investigate the total phenolic, flavonoid, tannin content, antioxidant activit...

  • Article
  • Open Access
9 Citations
3,352 Views
16 Pages

Inhibitory Effects of Caulerpa racemosa, Ulva intestinalis, and Lobophora challengeriae on Tyrosinase Activity and α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells

  • Pradtana Choosuwan,
  • Jantana Praiboon,
  • Korawinwich Boonpisuttinant,
  • Anirut Klomjit,
  • Narongrit Muangmai,
  • Rapeeporn Ruangchuay and
  • Anong Chirapart

3 April 2023

Melanogenesis involves a synthesis of melanin pigment and is regulated by tyrosinase. The addition of whitening agents with tyrosinase-inhibiting properties in cosmetics is becoming increasingly important. In this study, the ethanolic extracts from t...

  • Article
  • Open Access
158 Citations
21,213 Views
16 Pages

The Antinociceptive and Anti-Inflammatory Activities of Caulerpin, a Bisindole Alkaloid Isolated from Seaweeds of the Genus Caulerpa

  • Éverton Tenório De Souza,
  • Daysianne Pereira de Lira,
  • Aline Cavalcanti de Queiroz,
  • Diogo José Costa da Silva,
  • Anansa Bezerra de Aquino,
  • Eliane A. Campessato Mella,
  • Vitor Prates Lorenzo,
  • George Emmanuel C. De Miranda,
  • João Xavier De Araújo-Júnior and
  • Magna Suzana Alexandre-Moreira
  • + 4 authors

26 November 2009

The antinociceptive and anti-inflammatory activity of caulerpin was investigated. This bisindole alkaloid was isolated from the lipoid extract of Caulerpa racemosa and its structure was identified by spectroscopic methods, including IR and NMR techni...

  • Article
  • Open Access
13 Citations
3,332 Views
15 Pages

Clionasterol-Rich Fraction of Caulerpa racemosa against Particulate Matter-Induced Skin Damage via Inhibition of Oxidative Stress and Apoptosis-Related Signaling Pathway

  • N. M. Liyanage,
  • D. P. Nagahawatta,
  • Thilina U. Jayawardena,
  • H. H. A. C. K. Jayawardhana,
  • Hyo-Geun Lee,
  • Young-Sang Kim and
  • You-Jin Jeon

28 September 2022

The increasing airborne particulate matter (PM) consisting of environmental contaminants such as dust, aerosols, and fibers has become a global concern by causing oxidative stress that leads to apoptosis and skin damage. The current study evaluated t...

  • Article
  • Open Access
12 Citations
4,846 Views
19 Pages

Green Seaweed Caulerpa racemosa as a Novel Non-Small Cell Lung Cancer Inhibitor in Overcoming Tyrosine Kinase Inhibitor Resistance: An Analysis Employing Network Pharmacology, Molecular Docking, and In Vitro Research

  • Vincent Lau,
  • Fahrul Nurkolis,
  • Moon Nyeo Park,
  • Didik Setyo Heriyanto,
  • Nurpudji Astuti Taslim,
  • Trina Ekawati Tallei,
  • Happy Kurnia Permatasari,
  • Raymond R. Tjandrawinata,
  • Seungjoon Moon and
  • Bonglee Kim

12 June 2024

The marine environment provides a rich source of distinct creatures containing potentially revolutionary bioactive chemicals. One of these organisms is Caulerpa racemosa, a type of green algae known as green seaweed, seagrapes, or green caviar. This...

  • Article
  • Open Access
48 Citations
8,377 Views
10 Pages

Evaluation of Macroalgae Sulfated Polysaccharides on the Leishmania (L.) amazonensis Promastigote

  • Camila Lehnhardt Pires,
  • Selma Dzimidas Rodrigues,
  • Daniel Bristot,
  • Henrique Hessel Gaeta,
  • Daniela De Oliveira Toyama,
  • Wladimir Ronald Lobo Farias and
  • Marcos Hikari Toyama

20 March 2013

The sulfated polysaccharides from Solieria filiformis (Sf), Botryocladia occidentalis (Bo), Caulerpa racemosa (Cr) and Gracilaria caudata (Gc) were extracted and extensively purified. These compounds were then subjected to in vitro assays to evaluate...

  • Article
  • Open Access
4 Citations
1,762 Views
15 Pages

Cytotoxic and Anti-HSV-1 Effects of Caulerpin Derivatives

  • Gisely Maria Freire Abílio,
  • Cicera Janaine Camilo,
  • Henrique Douglas Melo Coutinho,
  • José Galberto Martins da Costa,
  • Lindomar José Pena,
  • Abelardo Silva-Júnior,
  • Yuri Mangueira do Nascimento,
  • José Maria Barbosa-Filho,
  • Bárbara Viviana de Oliveira Santos and
  • Kristerson Reinaldo de Luna Freire

15 August 2024

Marine organisms represent a potential source of secondary metabolites with various therapeutic properties. However, the pharmaceutical industry still needs to explore the algological resource. The species Caulerpa lamouroux Forssk presents confirmed...

  • Review
  • Open Access
40 Citations
7,614 Views
23 Pages

Therapeutic Potential and Nutraceutical Profiling of North Bornean Seaweeds: A Review

  • Muhammad Dawood Shah,
  • Balu Alagar Venmathi Maran,
  • Sitti Raehanah Muhamad Shaleh,
  • Wahidatul Husna Zuldin,
  • Charles Gnanaraj and
  • Yoong Soon Yong

25 January 2022

Malaysia has a long coastline surrounded by various islands, including North Borneo, that provide a suitable environment for the growth of diverse species of seaweeds. Some of the important North Bornean seaweed species are Kappaphycus alvarezii, Euc...

  • Article
  • Open Access
14 Citations
4,870 Views
13 Pages

Traditional Knowledge and Modern Motivations for Consuming Seaweed (Limu) in Samoa

  • Ulusapeti Tiitii,
  • Nicholas Paul,
  • Sarah Burkhart,
  • Silva Larson and
  • Libby Swanepoel

20 May 2022

Seaweeds are a traditional food throughout the Pacific. In Samoa, the edible seaweeds limu fuafua (sea grapes, Caulerpa racemosa and C. chemnitzia) and limu a’au (red seaweed, Halymenia durvillei and Halymenia sp.) are hand-harvested and consum...

  • Article
  • Open Access
24 Citations
4,165 Views
16 Pages

New Insight on In Vitro Biological Activities of Sulfated Polysaccharides from Ulvophyte Green Algae

  • Fahrul Nurkolis,
  • Rudy Kurniawan,
  • Isma Kurniatanty,
  • Moon Nyeo Park,
  • Myunghan Moon,
  • Siti Fatimah,
  • William Ben Gunawan,
  • Reggie Surya,
  • Nurpudji Astuti Taslim and
  • Bonglee Kim
  • + 1 author

Green algae are natural bioresources that have excellent bioactive potential, partly due to sulfated polysaccharides (SPs) which are still rarely explored for their biological activities. There is currently an urgent need for studies exploring the an...

  • Article
  • Open Access
32 Citations
5,944 Views
13 Pages

The Effects of Habitat Heterogeneity at Distinct Spatial Scales on Hard-Bottom-Associated Communities

  • Fabiane Gallucci,
  • Ronaldo A. Christofoletti,
  • Gustavo Fonseca and
  • Gustavo M. Dias

20 January 2020

For marine benthic communities, environmental heterogeneity at small spatial scales are mostly due to biologically produced habitat heterogeneity and biotic interactions, while at larger spatial scales environmental factors may prevails over biotic f...

  • Article
  • Open Access
4 Citations
1,863 Views
19 Pages

The Alkaloid Caulerpin Exhibits Potent and Selective Anti-Inflammatory Activity Through Interaction with the Glucocorticoid Receptor

  • Jônatas Sousa Pires dos Santos,
  • Dahara Keyse Carvalho Silva,
  • Vanessa da Silva Oliveira,
  • Sergio Santos Silva Junior,
  • Edivaldo dos Santos Rodrigues,
  • Claudia Valeria Campos de Souza,
  • Sabrina Teixeira Martinez,
  • Osvaldo Andrade Santos-Filho,
  • Cássio Santana Meira and
  • Milena Botelho Pereira Soares

29 May 2025

Inflammation plays a central role in various pathological conditions, necessitating the search for safer and more effective anti-inflammatory agents. This study investigates the anti-inflammatory activity of caulerpin, a bisindolic alkaloid isolated...

  • Article
  • Open Access
5 Citations
1,801 Views
29 Pages

Host-Mediated Antimicrobial Effects and NLRP3 Inflammasome Modulation by Caulerpin and Its Derivatives in Macrophage Models of Mycobacterial Infections

  • Maria Gabriella S. Sidrônio,
  • Maria Eugênia G. Freitas,
  • Daniel W. A. Magalhães,
  • Deyse C. M. Carvalho,
  • Vinícius A. B. Gonçalves,
  • Ana Caroline M. de Queiroz Oliveira,
  • Gisela C. Paulino,
  • Gabriela C. Borges,
  • Rafaelle L. Ribeiro and
  • Valnês S. Rodrigues-Junior
  • + 7 authors

Caulerpin, a bis-indole alkaloid isolated from Caulerpa racemosa, has several documented pharmacological activities, including antineoplastic and antiviral properties. This study aimed to evaluate the anti-inflammatory and anti-tubercular potentials...

  • Review
  • Open Access
13 Citations
7,518 Views
25 Pages

Could Natural Products Help in the Control of Obesity? Current Insights and Future Perspectives

  • Jiwon Park,
  • Fahrul Nurkolis,
  • Hyunji Won,
  • Jiye Yang,
  • Dayeon Oh,
  • Hyunkyung Jo,
  • Jinwon Choi,
  • Sanghyun Chung,
  • Rudy Kurniawan and
  • Bonglee Kim

13 September 2023

Obesity is a global issue faced by many individuals worldwide. However, no drug has a pronounced effect with few side effects. Green tea, a well-known natural product, shows preventive effects against obesity by decreasing lipogenesis and increasing...

  • Article
  • Open Access
5,410 Views
24 Pages

Seaweed Consumption Practices in Coastal Communities of Tawi-Tawi, Philippines

  • Albaris B. Tahiluddin,
  • Fauzia R. Esmola,
  • Suhana A. Abduraup,
  • Aisa Mae B. Camsain,
  • Wahaymin M. Jamil,
  • Angelica B. Bermil,
  • Romar A. Ujing,
  • Adzlan D. Gunong,
  • Samiya U. Damsik and
  • Rizal Jhunn F. Robles
  • + 9 authors

Seaweeds represent a vital yet often understudied component of the diet and cultural heritage of many coastal communities globally. This study investigated seaweed consumption practices in coastal communities of Tawi-Tawi, Philippines, through one-to...