Search Results (56)

Objective: Type B aortic dissection is a life-threatening medical condition. Endovascular closure of the primary entry by means of TEVAR is considered, nowadays, the gold standard if operative treatment is necessary. The aim of this study is to analyse the theoretical applicability of selective endovascular entry sealing using different occluder systems. Methods: A CT-graphic analysis of 102 patients who received TEVAR from January 2017 to June 2023 was performed. Patients with an intramural haematoma were excluded. The study patients were divided in two groups: type B aortic dissection (n = 87) and distal stent graft-induced new entry (n = 15). The TBAD group included patients with acute (n = 63), subacute (n = 12), and chronic aortic dissections (n = 12). The CTA analysis of the location, length, and width of the entry was performed using Aquarius iNtuition (TeraRecon, Inc., Foster City, CA, USA). After completion of the data collection, the possible application of all three occluder systems (ASD-Occluder, Septal-Occluder, and Amplatzer™-Occluder) was analysed, with reference to the Instructions for Use. Results: The ASD-Occluder from GORE is produced in five different sizes. It can be used in 81.4% (n = 83) of all patients in the overall study, including 82.8% TBAD (n = 72) and 73.3% of dSINE (n = 11) patients. When using the ASD-Occluder, 10.3% (n = 9) of patients are expected to have complete vascular coverage of the LSA based on our CTA analysis. The Septal-Occluder from GORE is offered in three different sizes. Complete entry closure can theoretically be achieved in fifty patients (57.5%) with TBAD and in nine patients (60%) with dSINE, based on CTA analysis and IFU criteria. With the use of the Septal-Occluder, 3.9% (n = 4) of the dSINE patients and 4.6% (n = 4) of the TBAD patients were expected to have complete aortic branch occlusion. The Amplatzer™-Occluder from Abbott is provided in 27 different sizes to effectively seal defects with a diameter of 4 to 56 mm. It can technically be used in 90.1% of patients (n = 92), of which 89.7% with TBAD (n = 78) and 93.3% with dSINE (n = 14) to completely seal the entry. Conclusions: CTA analysis in patients with TBAD and dSINE demonstrated that by the theoretical application of occluder systems, a seal of the entry would be achieved in 57.8% to 90.1% of the patients. However, in addition to entry closure, the use of occluder systems can also lead to unintentional partial (10.7–23.5%) or complete (3.9–22.5%) coverage of adjacent aortic branches. The clinical significance and applicability of the occluder system should be reviewed in future studies and practical applications to evaluate safety, efficacy, and possible complications in order to define the benefit–risk balance. Full article

Background: The global rise in the aging population presents significant challenges to healthcare systems, especially with increasing rates of chronic illnesses, mental health issues, and functional decline among older adults. In response, holistic and tech-driven approaches, such as telehealth and remote virtual interactive agents (VIAs), are potential emerging solutions to support the physical, cognitive, and emotional well-being of older adults. VIAs are multimodal digital tools that provide interactive and immersive experiences to users. Despite its promise, gaps still exist in the insights that explore ways of delivering geriatric healthcare remotely. Objective: This systematic review examines the existing literature on remote virtual interventions for older adults, focusing on bibliometrics, study purposes, outcomes, and network analysis of studies extracted from major databases using selected keywords and managed using the Covidence application. Methods and Results: Following five stages, namely, problem identification, a literature search, data evaluation, data analysis, and presentation, the review found that the studies on remote VIAs for older adults (2013–2025) were mostly from a positivist perspective, multi-authored, and U.S.-led, mainly showing positive outcomes for most studies (n = 13/15) conducted in home settings with healthy older participants. The dominance of positivist, US-led studies reflect an epistemological stance that emphasizes objectivity, quantification, and generalizability. VIAs, often pre-programmed and internet-based, supported health promotion and utilized visual humanoid avatars on personal devices. Keyword and network analysis additionally revealed four themes resulting from the review: Health and Clinical, Holistic and Cognitive, Home and Caring, and Hybrid and Connection. Conclusions: The review provides innovative insights and illustrations that may serve as a foundation for future research on VIAs and remote healthcare delivery for older adults. Full article

Sea Surface Salinity is a crucial climatic variable due to its twofold role as both a passive and an active tracer of oceanic processes. Despite its relevance, however, it could not be measured from space, mainly because of technological limitations, until 2009. Since then, the generation and assessment of satellite salinity has become a game-changer in physical and biogeochemical oceanography, as well as in climate science. Three satellite sensors with salinity-measuring capabilities (SMOS-Soil Moisture and Ocean Salinity, Aquarius, and SMAP-Soil Moisture Active Passive) have been launched in the previous decade, each characterized by specific measurement concepts and features and ad hoc validation approaches. The increasing usage of spaceborne salinity products has produced a variety of results and applications, which are here summarized under three specific domains: climate, scientific, and operational. Finally, short-to-mid-term perspectives, indicating both the expected improvements in terms of algorithms and also looking at novel mission concepts (that will provide continuation of these measurements in the decade to come) have been described. Full article

Mercury (Hg) contamination in soils poses significant environmental risks. In response, various nature-based solutions (NbSs) have been developed and studied in the past to treat mercury along with other heavy metals from both point and nonpoint sources. However, various land uses present uncertainties in mercury mobility and treatment efficiency, affecting the scalability of NbS systems. In this study, a systematic review of peer-reviewed articles addressing mercury pollution in NbS soils was conducted. Results revealed that lakeside environments and mining areas are key Hg accumulation zones due to hydrological connectivity and anthropogenic pressures. Constructed wetlands were the most studied NbSs, where those with Acorus calamus and Aquarius palifolius as the main vegetation achieved >90% Hg removal efficiencies. Although NbSs achieved high Hg removal, anaerobic conditions were found to promote MeHg formation, a critical drawback. Moreover, biochar demonstrated potential for immobilizing Hg and reducing bioavailability, though certain types increased MeHg formation under specific redox conditions. Overall, the study highlighted the need for site-specific design, long-term field evaluation, and multidisciplinary strategies to optimize NbS performance for mercury removal. Furthermore, future research on the scalability of mercury-treating NbSs across diverse land uses is recommended to address mercury risks and improve effectiveness. Full article

A novel electromyography (EMG)-based wheelchair interface was developed that uses contractions from the temporalis muscle to control a wheelchair. To aid in the training process for users of this interface, a serious training game, Limbitless Journey, was developed to support patients. Amyotrophic Lateral Sclerosis (ALS) is a condition that causes progressive motor function loss, and while many people with ALS use wheelchairs as mobility devices, a traditional joystick-based wheelchair interface may become inaccessible as the condition progresses. Limbitless Journey simulates the wheelchair interface by utilizing the same temporalis muscle contractions for control of in-game movements, but in a low-stress learning environment. A usability study was conducted to evaluate the serious-game-based training platform. A major outcome of this study was qualitative data gathered through a concurrent think-aloud methodology. Three cohorts of five participants participated in the study. Audio recordings of participants using Limbitless Journey were transcribed, and a sentiment analysis was performed to evaluate user perspectives. The goal of the study was twofold: first, to perform a think-aloud usability study on the game; second, to determine whether accessible controls could be as effective as manual controls. The user comments were coded into the following categories: game environment, user interface interactions, and controller usability. The game environment category had the most positive comments, while the most negative comments were primarily related to usability challenges with the flexion-based controller. Interactions with the user interface were the main topic of feedback for improvement in future game versions. This game will be utilized in subsequent trials conducted at the facility to test its efficacy as a novel training system for the ALS population. The feedback collected will be implemented in future versions of the game to improve the training process. Full article

Stem cells are unique, undifferentiated cells that have the ability to both replicate themselves and develop into specialized cell types. This dual capability makes them valuable in the development of regenerative medicine. Current development in stem cell research has widened their application in cell therapy, drug discovery, reproductive cloning in animals, and cell models for various diseases. Although there are substantial studies revealing the treatment of human degenerative diseases using stem cells, this is yet to be explored in livestock animals. Many diseases in livestock species such as mastitis, laminitis, neuromuscular disorders, autoimmune diseases, and some debilitating diseases are not covered completely by the existing drugs and treatment can be improved by using different types of stem cells like embryonic stem cells, adult stem cells, and induced pluripotent stem cells. This review mainly focuses on the use of stem cells for disease treatment in livestock animals. In addition to the diseases mentioned, the potential of stem cells can be helpful in wound healing, skin disease therapy, and treatment of some genetic disorders. This article explores the potential of stem cells from various sources in the therapy of livestock diseases and also their role in the conservation of endangered species as well as disease model preparation. Moreover, the future perspectives and challenges associated with the application of stem cells in livestock are discussed. Overall, the transformative impact of stem cell research on the livestock sector is comprehensively studied which will help researchers to design future research work on stem cells related to livestock diseases. Full article

Measurements of temperature, salinity, and currents in the Amazon River plume over a section in the open ocean of the western tropical North Atlantic (38°48′ W) are considered. The measurements were carried out using an AML Base X CTD probe in the upper layer and a flow-through system that measures salinity, turbidity, and chlorophyll-a content in seawater while a vessel is on the way. The measurements were supplemented by velocity profiling using shipborne SADCP. Additionally, archived oceanographic data from the World Ocean Database (WOD18), data on satellite altimetry measurements (AVISO), and satellite salinity data from Aquarius and SMOS were used. It is shown that the width of the Amazon River plume is about 170–400 km and the depth of desalination is from 50 to 100 m. Surface salinity decreases compared to the background (36.1) by 0.25 in February and by more than 3.0 in September during the period of maximum development of the plume, which was determined from satellite measurements of surface salinity. Lagrangian modeling of the back-in-time advection of passive markers simulating freshwater particles was carried out. It was shown that the source of freshwater in the measurement area is discharge from the Amazon River. Amazon River freshwater covered a distance of 3300 km in 60–80 days. The estimate of freshwater transport in the plume was 0.02 Sv, which is one order of magnitude smaller than the mean river discharge. Full article

Sea surface salinity (SSS) variability at mesoscales has become an important research topic in recent decades, thanks to satellite missions enabling observations of SSS with global capacity and mesoscale resolution. Here, we analyze the near-global data of the Aquarius/SAC-D along-track SSS, focusing on the slopes of SSS variance spectra in the mesoscale range from 180 to 430 km. In the vast extratropics, the spectral slope is close to −2, indicating a dynamical regime for the inverse cascade of depth-integrated energy identified by the surface quasi-geostrophic theory. However, the spectral slopes in regions near the mouths of the largest rivers are steeper than −2, reaching −3, possibly due to the large river freshwater flux. In addition, data from high-resolution thermosalinograph are used to validate satellite measurements and show good consistency in terms of SSS variance spectral slopes. Full article

Ocean salinity is a pivotal aspect of the ocean dynamic environment. Spaceborne L-band radiometers, like SMOS, Aquarius, and SMAP, offer a comprehensive approach to mapping out large-scale ocean salinity patterns. As China prepares for the launch of the Chinese Ocean Salinity and Soil Moisture Mission (COSM), it is essential to delve into the intricacies of radio frequency interference (RFI) detection, localization, and mitigation. The L-band, in particular, is highly susceptible to RFI. COSM will carry not one but two advanced instruments: a 2-D L-band aperture synthesis microwave radiometer (LASMR) and a 1-D L-C-K band microwave imager combined active and passive (MICAP). This article delves into the current state of RFI research, particularly in recent years, and introduces a fusion method that integrates MICAP and LASMR for more accurate RFI detection, localization, and mitigation. This fusion method relies on an algorithm that constructs localization and intensity objective functions based on the principle of least squares. By optimizing these functions, we can pinpoint the precise location and intensity of RFI. The resulting minimum mitigation residual offers a blueprint for achieving optimal RFI detection, localization, and mitigation. The experimental results, achieved in a controlled anechoic chamber, confirm that this fusion method—when weighted by variance—boosts detection accuracy, refines localization precision, and minimizes residual mitigation errors compared with standalone MICAP or LASMR techniques. Full article

Infertility is a major problem in farm animals, which has a negative economic effect on farm industries. Infertility can be defined as the inability of animals to achieve a successful pregnancy. Early pregnancy is crucial to establish a successful pregnancy, and it is reported that 70–80% and 20–30% of total embryonic loss occur in cattle and pigs, respectively, during the first month of pregnancy. The advanced high-throughput proteomics techniques provide valuable tools for in-depth understanding of the implantation process in farm animals. In the present review, our goal was to compile, assess, and integrate the latest proteomic research on farm animals, specifically focused on female reproduction, which involves endometrial tissues, uterine fluids, oviductal fluids, and microRNAs. The series of studies has provided in-depth insights into the events of the implantation process by unfolding the molecular landscape of the uterine tract. The discussed data are related to pregnant vs. non-pregnant animals, pregnancy vs. oestrous cycle, different days of the early pregnancy phase, and animals with uterine infections affecting reproduction health. Some of the studies have utilized non-invasive methods and in vitro models to decipher the molecular events of embryo-maternal interaction. The proteomics data are valuable sources for discovering biomarkers for infertility in ruminants and new regulatory pathways governing embryo-uterine interaction, endometrium receptivity, and embryonic development. Here, we envisage that the identified protein signatures can serve as potential therapeutic targets and biomarkers to develop new therapeutics against pregnancy diseases. Full article

Detecting hypermethylation of tumour suppressor genes could provide an alternative to liquid-based cytology (LBC) triage within HPV primary cervical screening. The impact of using the QIAsure^® FAM19A4/mir124-2 DNA Methylation Test (QIAGEN, N.V, Hilden, Germany) on CIN3+ diagnoses, retention, unnecessary colposcopies, and programme costs is unknown. A decision-tree model was developed to compare LBC with the QIAsure Methylation testing to guide colposcopy referral. Incorporating clinician- and self-sampling pathways the model was informed by the Dutch cervical cancer screening programme, published studies, and manufacturer data. Clinical and cost outcomes were assessed using two scenarios for DNA methylation testing and LBC relative performance. Sensitivity analyses (deterministic and probabilistic) were performed to assess model and parameter uncertainty. A range of self-sampling uptake was assessed in scenario analyses. For the screening cohort (n = 807,269) where 22.1% self-sampled, the number of unnecessary colposcopies and CIN3+ diagnoses varied according to the relative performance of methylation testing and LBC. Irrespective of relative performance, the cost per complete screen was lower and fewer people were lost to follow-up when using DNA methylation testing. The results indicate that, within an HPV primary screening programme that incorporates self-sampling, using the QIAsure Methylation Test for triage reduces the cost per screen compared to LBC. Full article

The dynamics of the satellite systems of Milky-Way-like galaxies offer a useful means by which to study the galaxy formation process in the cosmological context. It has been suggested that the currently observed anisotropic distribution of the satellites in such galaxy systems is inconsistent with the concordance $\mathsf{\Lambda }CDM$ cosmology model on the galactic scale if the observed satellites are random samples of the dark matter (DM) sub-halos that are nearly isotropically distributed around the central galaxy. In this study, we present original high-resolution zoom-in studies of central galaxies and satellite systems based upon initial conditions for the DM distribution from the Aquarius simulations but with substantial high-resolution baryon physics added. We find that the galaxy most like the Milky Way in this study does indeed contain a disk of satellites (DOS). Although one galaxy DOS system does not answer the question of how common such disks are, it does allow the opportunity to explore the properties and dynamics of the DOS system. Our investigation centers on the spatial arrangement (distances, angles, etc.) of satellites in this Milky-Way-like galaxy system with a specific emphasis on identifying and analyzing the disk-like structure along with its dynamical and morphological properties. Among the conclusions from this study, we find that the satellites and DM sub-halos in the galaxy simulations are anisotropically distributed. The dynamical properties of the satellites, however, indicate that the direction of the angular momentum vector of the whole satellite system is different from the normal direction of the fitted DOS and from the normal direction of the velocity dispersion of the system. Hence, the fitted DOS appears to be comprised of infalling sub-halos and is not a rotationally supported system. Full article

A new species of gall crab collected from elegance coral, Catalaphyllia jardinei, is described in this paper. The male holotype was collected from a reef tank in Germany in 2016, and it is described here using integrative taxonomy. This species, named Lithoscaptus aquarius sp. nov., is the thirteenth assigned to the genus. It is morphologically and phylogenetically closest to Lithoscaptus semperi, a cryptochirid associated with Trachyphyllia geoffroyi. Like L. semperi, it has a large, broad W-shaped depression on the anterior half of the carapace, but the carapace surface of L. aquarius sp. nov. is smooth overall, lacking spines or tubercles. This new species is so named because it was found in a reef tank after searching in vain for material during fieldwork campaigns over the course of several years. Full article

The emergence of political polarization in Europe has intensified divisions among citizens regarding immigration, inequality, and racism. The present paper investigates the use of ver-based (“see”-based) evidentiality in positioning and repositioning strategies by conservative Spanish readers of the digital newspapers ABC and La Razón. The study focuses on their responses to two different controversial measures involving immigrants and refugees taken in by the Spanish government. Such measures relate to the Aquarius (2018) and the Open Arms (2019) incidents. The analysis will be corpus, content-based, and grounded in positioning theory and theories of visual evidential perception. The ultimate aim is to explore the instances of ver-based evidentiality introducing positioning and repositioning strategies that are present in the corpus. Subsequently, we will classify and analyze the viewpoints expressed by conservative readers through these ver-based evidential markers. Full article

Internal waves (IWs) are generated in all the oceans, and their amplitudes are large, especially in regions that receive a large amount of freshwater from nearby rivers, which promote highly stratified waters. When barotropic tides encounter regions of shallow bottom-topography, internal tides (known as IWs of the tidal period) are generated and propagated along the pycnocline due to halocline or thermocline. In the North Indian Ocean, the Bay of Bengal (BoB) and the Andaman Sea receive a large volume of freshwater from major rivers and net precipitation during the summer monsoon. This study addresses the characteristics of internal tides in the BoB and Andaman Sea using NASA’s Estimating the Circulation and Climate of the Ocean (ECCO) project’s high-resolution (1/48° and hourly) salinity estimates at 1 m depth (hereafter written as ECCO salinity) during September 2011–October 2012, time series of temperature, and salinity profiles from moored buoys. A comparison is made between ECCO salinity and NASA’s Soil Moisture Active Passive (SMAP) salinity and Aquarius salinity. The time series of ECCO salinity and observed salinity are subjected to bandpass filtering with an 11–14 h period and 22–26 h period to detect and estimate the characteristics of semi-diurnal and diurnal period internal tides. Our analysis reveals that the ECCO salinity captured well the surface imprints of diurnal period internal tide propagating through shallow pycnocline (~50 m depth) due to halocline, and the latter suppresses the impact of semi-diurnal period internal tide propagating at thermocline (~100 m depth) reaching the sea surface. The semi-diurnal (diurnal) period internal tides have their wavelengths and phase speeds increased (decreased) from the central Andaman Sea to the Sri Lanka coast. Propagation of diurnal period internal tide is dominant in the northern BoB and northern Andaman Sea. Full article