Search Results (263)

(1) Background: Neonatal sepsis continues to be one of the leading causes of mortality and morbidity, particularly in underdeveloped countries. We aimed to compare laboratory parameters between clinical early-onset sepsis (clinEOS) and NNNon-clinEOS groups and to evaluate the association between TLR2-Arg753Gln, TLR4-Asp299Gly, IL6-174G/C, and IL10-1082G/A gene single-nucleotide polymorphisms and clinical EOS susceptibility in preterm newborns. (2) Materials and Methods: Genotyping of the TLR2, TLR4, IL6, and IL10 polymorphisms was performed in 36 preterm neonates with polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis (RFLP). Logistic regression analysis was used to test the associations between the studied gene polymorphisms and EOS susceptibility. (3) Results: Statistically significant differences in gestational age and birth weight were observed between the two groups, with preterm neonates with clinical EOS having a lower mean gestational age (mean (SD): 29.4 (2.8) weeks vs. 32.6 (1.1); p = 0.00002) and a lower mean birth weight (1342.1 (446.5) gr. Vs. 1984 (376.9)) than preterm neonates without clinical EOS. C-reactive protein (CRP) values measured on the first day significantly increased in the clinEOS group compared with the non-clinEOS group (median, 95% CI: 0.80 [0.40, 1.15] vs. 0.30 [0.02, 0.50]). The mean number of neutrophils significantly decreased in the preterm neonates with clinical EOS (mean difference: 17.3%; 95% CI: [4.0%, 30.5%]; p = 0.0126) and non-clinEOS group (mean difference: 20.8%; 95% CI: [1.8%, 39.9%]; p = 0.0354) between the first and seventh hospitalization days. In the dominant model, the A/G + A/A variant genotype of the IL10-1082G/A polymorphism significantly increased the odds of clinical EOS compared with the GG genotype (OR = 5.25; p = 0.0322), but the gestational-age-group adjusted model yielded p = 0.0752. (4) Conclusions: The results of the current study suggest that IL10-1082G/A gene polymorphism is a significant risk factor for clinical early-onset sepsis development in preterm neonates, but there was no evidence of a gestational age-group independent direct effect of IL10-1082G/A gene polymorphism on clinical EOS susceptibility. The results should be considered as exploratory. Full article

Atractylenolides (ATs; mainly AT-I, II, and III), as one of the primary active components of the traditional Chinese medicine Atractylodes macrocephala, have demonstrated significant antitumorigenic effects against various cancer cells in both in vitro and in vivo studies. This review aims to systematically review the antitumorigenic effects, mechanisms, pharmacokinetics, and safety profile of ATs, aiming to contribute to clinical research and applications. To achieve this, a systematic literature search was conducted across multiple databases, and findings were synthesized narratively to provide a comprehensive overview of the current evidence. This review comprehensively discusses the antitumorigenic effects and mechanisms of ATs, including arresting tumor cell cycle progression, inducing programmed cell death (apoptosis, autophagy, and ferroptosis), inhibiting tumor angiogenesis, suppressing tumor migration and invasion, modulating the tumor immune microenvironment, and enhancing the efficacy of combination therapies. Additionally, their pharmacokinetic properties and safety profile are summarized, with a focus on their research and application prospects. ATs appear to be safe and reliable candidate anticancer agents in preclinical models, exhibiting potent antitumor efficacy both as monotherapy and in combination regimens. Preliminary clinical data from a small pilot study also indicated no signs of toxicity, but more extensive trials are needed to confirm their safety profile in humans. Further studies on their mechanisms are warranted to facilitate their development into clinically effective antitumor agents. Full article

Background/Objectives: There is limited data regarding the association of anti-drug antibody (ADA) levels with the efficacy of anti-tumor necrosis factor (anti-TNF) therapy in patients with inflammatory bowel disease (IBD). We aimed to investigate the association between antibody to adalimumab (ATA) and antibody to infliximab (ATI) levels and treatment failure in IBD. Methods: This single-center, retrospective cohort study included consecutive IBD patients with ADA evaluated with a drug-tolerant assay between September 2012 and February 2023. A time-to-event analysis was performed for treatment failure, defined as the need for drug discontinuation due to primary non-response, loss of response, a serious adverse event, or an IBD-related surgery. Patients were followed from first positive ADA until treatment failure or the end of the follow-up (May 2024). Results: The study population consisted of 134 patients with IBD [n = 58 (43%) on adalimumab; n = 86, (64%) with Crohn’s disease]. Multiple COX regression analysis identified higher ADA levels to be associated with treatment failure (HR: 1.034, 95%CI: 1.024–1.045, p < 0.001). A ROC analysis identified an ATA and ATI level threshold of 5.2 U/mL (AUC: 0.705; 95%CI: 0.569–0.841; p = 0.003; sensitivity: 64%; specificity: 82%) and 8.8 U/mL (AUC: 0.809; 95%CI: 0.713–0.906; p < 0.001; sensitivity: 69%; specificity: 93%), respectively, to distinguish patients with or without treatment failure. Conclusions: In this large retrospective cohort study, higher levels of ADA were associated with treatment failure to anti-TNF therapy in IBD. Moreover, we identified ATA and ATI level thresholds of 5.2 U/mL and 8.8 U/mL, respectively, to be associated with treatment failure. Full article

Oil palm (Elaeis guineensis), a rapidly expanding crop in northeastern Pará, first emerged in the 1970s as a crucial response to the global oil crisis. However, its swift expansion has subsequently generated significant socio-environmental conflicts, profoundly altering local socioecological dynamics. Therefore, we aimed to investigate land-use and land-cover changes within the headwater sub-basin of the Caeté River, focusing specifically on the municipality of Bonito, Pará. To achieve this, we employed remote sensing and geospatial analysis to accurately delineate the study area and perform supervised classifications. Specifically, we used the Random Forest algorithm to map five distinct periods: 1985, 1995, 2004, 2015, and 2023. In addition, we calculate an Anthropogenic Transformation Index (ATI) in order to observe the human influence in the landscape. Our classification models exhibited high accuracy, with overall accuracy values ranging from 0.63 to 0.87 and Kappa coefficients between 0.53 and 0.76, demonstrating consistent discrimination among LULC classes. The results revealed a marked transformation of the landscape, with oil palm monocultures progressively expanding at the expense of dense forest and human-modified vegetation. For instance, the ATI increased from 3.14 in 1985 to 5.56 in 2004, followed by a slight decline to 4.90 in 2023, suggesting a potential stabilisation—but not a reversal—of anthropogenic pressures. Nonetheless, the negative socioecological impacts of the oil palm monocultures in this Amazonian landscape remain severe, encompassing issues such as water pollution and ongoing socio-environmental conflicts. In conclusion, this research highlights the importance of understanding these dynamics to support sustainable management of the Caeté River basin. Furthermore, we underscore the urgent need for further research to rigorously evaluate effective mitigation strategies and foster genuinely sustainable development within the region. Full article

Objective: The aim of this study was to evaluate the consistency and reproducibility of attenuation coefficient (AC) measurements using different commercial ultrasound (US) across via a phantom experiment to investigate the relationship between the AC and MRI-derived proton density fat fraction (MRI-PDFF) values and the conversion equation. Methods: Twelve phantoms containing varying fat proportions (0–100%) were constructed. Phantom ACs were estimated via three US attenuation systems, including attenuation imaging (ATI), ultrasound attenuation analysis (USAT), and the US-guided attenuation parameter (UGAP), along with MRI-PDFF. Agreement among the AC values from the three ultrasonic attenuation systems was evaluated. Linear correlation analysis was used to explore the ACs, fat concentrations of the phantom, and MRI-PDFF measurements, from which a linear conversion formula between the ultrasonic attenuation parameters and the MRI-PDFF was derived. Results: MRI-PDFF and phantom fat concentration measurements appeared with a strong linear correlation (R² = 0.996, p < 0.001). For the three US attenuation parameters, both inter-operator and intra-operator intraclass correlation coefficients (ICCs) ranged from 0.990 to 0.995 and 0.989 to 0.995, respectively. Bland–Altman analysis revealed no significant differences between the above three (all p > 0.05). Significant linear relationships were demonstrated between ultrasound attenuation parameters and phantom fat concentration (r = 0.938–0.986; all p < 0.001), as well as between ultrasound attenuation parameters and MRI-PDFF values (r = 0.922–0.982; all p < 0.001). A conversion formula (fat proportions ≤ 50%) was derived: US (dB/cm/MHz) = 0.501 + 0.012 MRI-PDFF (%). Conclusions: AC across different commercial ultrasound devices demonstrated significant diagnostic value in fat concentrations that appeared good consistency in measuring phantom fat concentration both between and within groups. The linear relationship between AC and MRI-PDFF enables the application of a conversion formula. Full article

Ship targets are usually high-value targets, and synthetic aperture radar (SAR) moving ship indication is of great importance in maritime traffic monitoring. However, due to the motion of the ocean, maritime ships may have rotational motion in addition to the conventional translational motion. The rotational motion, including the yaw, pitch, and roll, will cause the signal characteristics of the ship to become very complex, which increases the difficulty of designing moving target indication methods. This paper studies the effect of each rotation motion on the ship’s signal characteristics in image domain for spaceborne multichannel SAR. Firstly, the range equation of an arbitrary scatterer on the ship with both rotational and translational motions is developed. Then, the influences of each rotation motion on the coefficients of the range equation and the scatterer’s along-track interferometric (ATI) phase are revealed. Finally, numerical experiments are conducted to investigate the effect of each rotation motion on the scatterer’s azimuth position shift, azimuth defocusing, azimuth sidelobe symmetry, and ATI phase, which are important parameters for moving target indication. Full article

Background/Objectives: Sarcopenia, an underdiagnosed musculoskeletal disorder, is a serious cause of disability, poor quality of life, and healthcare costs in an increasingly elderly population. This study aimed to examine an ultrasound (US)-based, inexpensive, simple, and reproducible alternative to magnetic resonance imaging (MRI) for assessing muscle quality. A study compared Dixon MR fat fraction with US attenuation imaging (ATI) and echo intensity (EI) in the rectus femoris (RF) and biceps brachii (BB). Methods: The US images were acquired from 34 participants who had previously received a whole-body MRI. The ATI measurements were carried out using a linear array on a Canon Aplio i800 scanner. The measurements of EI were assessed by manually tracing the cross-sectional border of the right RF and BB muscles. Corresponding T1-weighted Dixon VIBE-based fat and water images were required for the MRI fat fraction percentage (MR %FF) measurements. Results: Using Pearsons correlation coefficient, a good correlation was found between MR %FF and EI measurements. The results between operators’ measurements showed a strong correlation and were highly repeatable. Attenuation imaging revealed no correlation with MR %FF or EI. Conclusions: Echo intensity offers a low-cost, non-invasive, and widely accessible US-based imaging modality for screening patients at risk for sarcopenia. No correlation was found between the ATI and MR %FF or between the ATI and EI. Further adapted protocols and software adjustments are needed so that ATI has the potential to prove itself as an additional US-based method for assessing fat infiltration in muscles. Full article

This study assessed the performance of the Clouds and the Earth’s Radiant Energy System (CERES) surface longwave downward radiation (SLDR) products under the atmospheric temperature inversion (ATI) conditions for the first time. Three years of ground-measured SLDRs from 409 globally distributed stations across four flux networks were employed, and the collocated MODIS atmospheric profile product was used to identify the ATI profiles at each flux station. All three SLDR estimate algorithms (Models A, B, and C) show a pronounced accuracy decline under ATI conditions, regardless of region (polar or non-polar) or time of day (daytime or nighttime). Under ATI conditions, the Bias/RMSE increases by approximately 10.0/5.0 W/m² for Models A and B, 5.0/1.0 W/m² for Model C. Sensitivity analysis reveals that the concurrent atmospheric moisture inversion (AMI) compounds this degradation; both the Bias and RMSE increase with the AMI intensity. These results underscore the need to refine CERES SLDR algorithms in the future. Full article

The synthesis of biocidal peptide materials using simple, low-cost, solvent-free methods is a crucial challenge for developing new antimicrobial approaches. In this study, we produced proteinoid nanostructures through simple, inexpensive, and environmentally friendly thermal reactions between glutamic acid (Glu) and tyrosine (Tyr) in various molar ratios. Mechanistically, the thermal cyclization of glutamic acid into pyroglutamic acid (pGlu) facilitated the formation of short peptide chains containing pGlu as the N-terminus moiety and subsequent L-tyrosine or glutamic acid residues, which self-assembled into nanometric spheroidal structures that exhibit blue emission. Spectroscopic (FTIR, UV-Vis, photoluminescence) and mass (LC-MS) analyses confirmed the formation of mixed pGlu-/Tyr/Glu peptides. All products exhibit dose-dependent antimicrobial activity against Methicillin-Resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 25 mg mL⁻¹ for the GluTyr 1:1 and 2:1 proteinoids. The outcomes observed following 24 h exposure of the HEK293 cell line to the materials indicate their suitability for integration into hybrid systems for antimicrobial surfaces. This work is the first to demonstrate a direct antibacterial activity of proteinoids obtained by thermal condensation, opening up the possibility of designing a new class of synthetic antimicrobial peptides. Full article

Background: Anemia and iron deficiency (ID) affect children and are regarded as a major public health problem in developing countries. This study aimed to evaluate the prevalences of anemia and ID in Tunisian children aged 6 to 12 years and to identify their associated risk factors. Methods: A nationwide cross-sectional survey was conducted across the seven major regions of Tunisia. A total of 2610 schoolchildren were selected using a two-stage random sampling method. Venous blood was collected to measure hemoglobin and ferritin for iron status determination. C-reactive protein (CRP) and Alpha-1-acid glycoprotein (AGP) were also measured to establish the inflammatory status of children. Multivariable logistic regression models were performed to identify factors associated with anemia and ID. Results: Anemia affected 5.7% of children, similarly between girls and boys. A quarter of children had ID and iron deficiency anemia (IDA) was diagnosed in 42% of the anaemic schoolchildren. In rural areas, girls were more affected by ID than boys whereas no significant difference was observed for anemia between both genders. Multivariate analysis revealed that insufficient consumption of iron-rich foods significantly increased the risk of ID (OR = 1.40; 95% CI [1.05–1.85]; p = 0.021). Children in public schools were 1.74 times more likely to be at risk of ID (95% CI [1.34–2.21]; p = 0.004) than those in private schools. Conclusions: To alleviate the burden of ID, national interventions should focus on iron supplementation, food diversification, nutritional education and regular longitudinal studies. Full article

Active compounds used in agriculture are mainly in the form of acids. This applies primarily to substances that are inducers of systemic acquired resistance, which is one of the most promising methods of supporting plants in the fight against pathogens. The physicochemical properties and biological activity of such substances can be improved by derivatizing them to salt forms. We used the concept of ionic liquids to obtain novel compounds in the form of chlormequat ionic liquids. In this study we present synthesis and characterization of a series of novel ionic liquids composed of the chlormequat cation paired with plant resistance-inducing anions, including salicylic acid and its chlorinated derivatives, nicotinic acid and isonicotinic acid. The results indicate that the new compounds in the form of salts are characterized by better biological activity related to SAR induction and lower phytotoxicity compared to the parent compounds as their equivalents in acid forms. The obtained compounds demonstrated the ability to activate defense responses in tobacco and to reduce susceptibility to viral infection, highlighting their potential for further application in crop protection. Full article

Nowadays, nonalcoholic fatty liver disease (NAFLD) represents the most common cause of chronic liver disorder worldwide. From the clinical point of view, it evolves from steatosis to nonalcoholic steatohepatitis, which can lead to cirrhosis and finally to hepatocellular carcinoma. The mechanisms involved in its progression to more pathological stages and NAFLD pathogenesis are not completely understood. The research concerning NAFLD has become urgent and important because the age of NAFLD diagnosis is progressively decreasing, and its relationship with cancer risk is already well known. Because NAFLD ultimately leads to disability and imposes a major socioeconomic burden, timely diagnosis and effective treatment of NAFLD is particularly important. In the development of NAFLD, noncoding RNAs (ncRNAs) represented by microRNAs, long noncoding RNAs, circular RNAs, and piRNAs are epigenetic factors that play important regulatory roles. In the current review, we present updated information regarding the role of miRNAs, lncRNAs, circRNAs, and piRNAs, aiming to develop a good understanding of their regulatory functions in hepatic metabolism and concerning their potential use as biomarkers for early NAFLD/NASH diagnosis and as therapeutic targets. Full article

This study investigates the effects of multi-angle along-track interferometric synthetic aperture radar (ATI-SAR) observations on the accuracy of sea surface current retrieval. Utilizing a high-fidelity, full-link SAR ocean simulator, this study systematically assesses the influence of three key factors—the angle between observation directions, the relative orientation of wind and current, and wind speed—on the precision of two-dimensional (2D) current vector retrievals. Results demonstrate that observation geometry is a dominant factor: retrieval errors are minimized when the two viewing directions are near-orthogonal (~90°), while near-parallel (0° or 180°) geometries result in significant error amplification. Furthermore, the angle between wind and current introduces complex, non-linear error characteristics, with a perpendicular alignment minimizing velocity error but maximizing direction error. Higher wind speeds are found to degrade both velocity and direction retrieval accuracy. Collectively, these findings provide crucial quantitative guidance for optimizing the mission design, observation planning, and algorithm development for future multi-angle ATI-SAR satellite constellations dedicated to ocean current monitoring. Full article

Autism diagnosis through magnetic resonance imaging (MRI) has advanced significantly with the application of artificial intelligence (AI). This systematic review examines three computational paradigms: radiomics-based machine learning (ML), deep learning (DL), and hybrid models combining both. Across 49 studies (2011–2025), radiomics methods relying on classical classifiers (i.e., SVM, Random Forest) achieved moderate accuracies (61–89%) and offered strong interpretability. DL models, particularly convolutional and recurrent neural networks applied to resting-state functional MRI, reached higher accuracies (up to 98.2%) but were hampered by limited transparency and generalizability. Hybrid models combining handcrafted radiomic features with learned DL representations via dual or fused architectures demonstrated promising balances of performance and interpretability but remain underexplored. A persistent limitation across all approaches is the lack of external validation and harmonization in multi-site studies, which affects robustness. Future pipelines should include standardized preprocessing, multimodal integration, and explainable AI frameworks to enhance clinical viability. This review underscores the complementary strengths of each methodological approach, with hybrid approaches appearing to be a promising middle ground of improved classification performance and enhanced interpretability. Full article

Recent advances in energy conversion technologies, especially solar-driven photocatalytic water splitting, are vital for satisfying the increasing global need for sustainable and clean energy. Perovskite oxides have attracted considerable attention among photocatalytic materials due to their tunable electronic structures, exceptional stability, and promise for effective hydrogen generation and environmental remediation. In this study, the optoelectronic and photocatalytic (PC) characteristics of ATiO₃ (A = Ca, Mg) perovskites, undoped and codoped with Se and Zr, have been analyzed using ab initio simulations based on the density functional theory (DFT). The calculated formation energies for codoped systems range from −1.01 to −3.32 Ry/atom, confirming their thermodynamic stability. Furthermore, band structure calculations indicate that the undoped compounds CaTiO₃ and MgTiO₃ possess indirect band gaps of 2.766 eV and 2.926 eV, respectively. In contrast, codoping alters the electronic properties by changing the band gap from indirect to direct and reducing its energy, resulting in the direct band gap values 2.153 eV, 1.374 eV, 2.159 eV, and 1.726 eV for the compounds ${{\mathrm{C}\mathrm{a}}_8\mathrm{T}\mathrm{i}}_7{\mathrm{Z}\mathrm{r}}_1{\mathrm{O}}_{23}{\mathrm{S}\mathrm{e}}_1$, ${{\mathrm{C}\mathrm{a}}_8\mathrm{T}\mathrm{i}}_6{\mathrm{Z}\mathrm{r}}_2{\mathrm{O}}_{22}{\mathrm{S}\mathrm{e}}_2$, ${{\mathrm{M}\mathrm{g}}_8\mathrm{T}\mathrm{i}}_7{\mathrm{Z}\mathrm{r}}_1{\mathrm{O}}_{23}{\mathrm{S}\mathrm{e}}_1$, and ${{\mathrm{M}\mathrm{g}}_8\mathrm{T}\mathrm{i}}_6{\mathrm{Z}\mathrm{r}}_2{\mathrm{O}}_{22}{\mathrm{S}\mathrm{e}}_2$, respectively. Additionally, this codoping improves light absorption and optical conductivity in the visible and ultraviolet ranges. These enhancements become increasingly evident with elevated dopant concentrations, leading to intensified light–matter interactions. Analysis of the band edge potentials reveals that the Se-/Zr-codoped CaTiO₃ compounds satisfy the necessary criteria for the photodissociation of water, conferring on them an ability to generate H₂ and O₂ under light irradiation. However, under different pH conditions, Se-/Zr-codoped MgTiO₃ is expected to perform better at higher pH levels, while Se-/Zr-codoped CaTiO₃ is more effective at lower pH levels. These findings highlight the promise of codoped materials for renewable energy applications, such as solar-driven hydrogen production and optoelectronic devices, with pH being a critical factor in enhancing their photocatalytic performance. Full article