Search Results (120)

Objective and Background: With the increasing use of catheter ablation for tachyarrhythmias, continuous evaluation of in-hospital complications is essential. This study aimed at analyzing complications associated with catheter ablation for atrial fibrillation (AF), atrial flutter (AFL), and ventricular tachycardia (VT) using nationwide administrative data. Methods: We conducted a retrospective multicentric data analysis from large German ablation centers between 2018 and 2023. Patients were identified using ICD and OPS codes for AF, AFL, and VT regarding predefined in-hospital complications: mortality, stroke, pericardial tamponade, pulmonary embolism, and vascular complications requiring intervention. Results: Among 19,258 ablation procedures from 11 centers, AF was most common (n = 12,241), followed by AFL (n = 5582) and VT (n = 1435). Major complications occurred in 2.2% (n = 433) of cases. VT ablations had the highest complication rate (9.8%), followed by AF (1.6%) and AFL (1.7%). Pericardial tamponade occurred in 0.9% patients, most commonly in VT ablations (4.0%). Vascular complications requiring intervention were reported in 1.1%, while stroke (0.3%) and pulmonary embolism (0.05%) were rare. In-hospital mortality was highest in VT patients (2.4%), compared to AF (0.08%) and AFL (0.13%). Higher AFL mortality as compared to AF was associated with older age and more comorbidities. Upon exploratory analysis, no statistical association between hospital volume and complication rates could be seen. Conclusions: In this multicenter analysis, catheter ablation was associated with a low overall complication rate. VT ablations carried the highest risk, highlighting the impact of structural heart disease and comorbidities. Full article

Background: Pediatric thoracic magnetic resonance imaging (MRI) has evolved into a valuable diagnostic modality that offers high-resolution morphological and functional assessment. While conventional radiography and computed tomography (CT) remain standard, their radiation exposure poses significant risks in children requiring repeated imaging. Technological innovations have addressed prior MRI limitations such as low lung proton density and motion artifacts, expanding its role in pediatric thoracic imaging. Methods: A review of the recent literature was performed, focusing on technical advancements, key MRI sequences and clinical applications in pediatric thoracic imaging. Emphasis was placed on ultrashort echo time (UTE), phase-resolved functional lung (PREFUL) MRI, hyperpolarized xenon-129 MRI, radial imaging, compressed sensing, parallel imaging and respiratory gating techniques. Results: Modern MRI sequences provide both detailed anatomic visualization and quantitative functional assessment of the pediatric thorax. UTE and PREFUL enable evaluation of lung parenchyma, ventilation, and perfusion, while hyperpolarized gas imaging offers high-resolution functional mapping. Radial, compressed sensing and parallel imaging reduce motion artifacts and acquisition times, enhancing feasibility in uncooperative children. Clinical indications include assessment of congenital malformations, chronic lung disease like cystic fibrosis, infectious and inflammatory disorders, tumors and selected traumatic injuries. Conclusions: Recent technical advances have established pediatric thoracic MRI as a versatile, patient-friendly alternative, as well as a complementary method to CT in selected clinical scenarios. Ongoing developments in acquisition speed, motion compensation and functional imaging are expected to further improve diagnostic accuracy and clinical utility, supporting broader adoption in routine pediatric thoracic evaluation. Full article

Sperm cryopreservation produces a series of physicochemical phenomena that negatively impact the function and structure of spermatozoa, including the mobilization of cholesterol from the plasma membrane. The use of attenuated total reflection–Fourier-transform infrared spectroscopy (ATR-FTIR) may be useful to measure the cholesterol efflux in goat spermatozoa. Therefore, the objective of this study was to standardize the use of ATR-FTIR to measure the efflux of cholesterol in goat spermatozoa. Standardization of the technique was carried out in three stages: (i) determination of the appropriate sperm concentration to detect cholesterol in the FTIR spectrum; (ii) determination of the minimum percentage of viable spermatozoa required to observe at least five spectral bands in common with pure cholesterol; (iii) assessment of cholesterol removal in frozen–thawed spermatozoa. Possible differences in the areas of the spectral bands were compared by one-way ANOVA. Nineteen spectra were obtained: pure cholesterol, sperm transport medium, five different sperm concentrations, and ten live/dead sperm proportions (heat and cold-killed). The lowest sperm concentration at which spectral bands were clearly identified was 13 × 10⁶ sperm/mL. Regarding viability, the cut-off value was 50%: higher values produced spectral bands clearly detectable, whereas in smaller values, the band’s areas decreased sharply, making it difficult to quantify them. Five areas of the cholesterol bands decreased in thawed samples compared to fresh spermatozoa; an increase in the proportion of frozen–thawed sperm showing Merocyanine brilliant pattern, indicative of high fluidity, as well as an increase in the proportion of CTC AR pattern, indicative of acrosome reaction, support those results. In conclusion, ATR-FTIR is a useful technique for identifying the movement of cholesterol in goat buck spermatozoa. Full article

With the rapid economic and social development and the increasingly severe water shortage situation, the sustainable utilization of unconventional water resources is of great significance. As one of the “second water sources”, the full utilization of highly mineralized mine water (HMMW) is a key strategy for promoting sustainable development in water-scarce regions. It has obvious resource, environmental, and economic benefits that are central to sustainability. However, the mechanism of the impact of HMMW utilization on water utilization, the environment, and the economy is still unclear, making it difficult to evaluate its overall sustainability performance and to provide scientific data support to promote HMMW utilization. Therefore, this paper develops a novel sustainability-oriented accounting framework to assess the environmental–economic sustainability of HMMW utilization. Firstly, this paper proposes the method of calculating the HMMW utilization environmental benefits, proposes a novel integrated environmental–economic input–output accounting framework, which refines the HMMW sector from the traditional water industry and integrates the environmental benefits into a balanced input–output table. Secondly, taking Ningdong Energy Chemical Industry Base (NECI Base) as an example, this paper conducts applied research on the integrated environmental–economic accounting of HMMW utilization: (I) The HMMW environmental benefits of NECI Base are calculated, the utilization of 22.69 million m³ of HMMW generated environmental benefits, valued at 233.69 million CNY, demonstrating its substantial contribution to environmental sustainability. The compiled environmental–economic input–output table passed the balance verification, confirming the robustness and practicality of the accounting method. Full article

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, marked by Schwann cell dysfunction, demyelination, and impaired nerve regeneration. Although Schwann cells undergo phenotypic changes under hyperglycemic conditions, the underlying molecular mechanisms remain unclear. This study aimed to examine the effects of high glucose on Schwann cell phenotype and assess the involvement of the mTOR signaling pathway. Primary Schwann cells were isolated from rat sciatic nerves and cultured in media containing 5 mM (control), 25 mM, or 50 mM glucose for five days. Immunofluorescence staining and corrected total cell fluorescence (CTCF) analysis were used to evaluate expression of key markers: c-Jun, Krox-20, p75^NTR, MBP, mTOR, phosphorylated mTOR (Ser2448), and AKR1B1. Among these, significant changes were observed in MBP (p = 0.002), total mTOR (p = 0.001), and phosphorylated mTOR (Ser2448) (p = 0.0179), indicating impaired mTOR activation and loss of myelin protein expression. Non-significant changes in the other markers are discussed as preliminary observations. These findings highlight mTOR dysregulation and impaired myelin protein expression as central features of Schwann cell responses to hyperglycemia, which may contribute to the development of DPN. Full article

Background: Post-colonoscopy syndrome is an emerging clinical entity characterised by the onset of gastrointestinal symptoms following a colonoscopy. The current management of this syndrome has not yet been established, although probiotics have been proposed. The therapeutic potential of a combination nutraceutical compound based on HBQ-Complex^®, butyrate, and probiotics (Lactobacillus acidophilus, Bifidobacterium animalis, and Lactiplantibacillus plantarum) in this setting remains unknown. Methods: A retrospective, multicentre, observational study was conducted in adult patients undergoing colonoscopy in the absence of known gastrointestinal diseases, assessing the onset of upper and lower gastrointestinal symptoms post-colonoscopy immediately after the procedure (T₀), at 2 weeks (T₁), and 4 weeks (T₂) thereafter, using a VAS (0–10). Two groups were analysed, one undergoing nutraceutical supplementation and a control group. Results: A total of 599 patients were included (64.9% receiving nutraceutical supplementation and 35% in the control group). Several variations were observed involving the treated group compared to the control for abdominal pain (59.9% vs. 33.3%), meteorism (64.9% vs. 35.1%), diarrhoea (46.9% vs. 19.5%), and bloating (59.3% vs. 26.7%) (p < 0.001 for all). Logistic regression analysis showed a reduction in constipation (OR: 3.344) and bloating (OR: 3.791) scores. Conclusions: Nutraceutical supplementation based on this combinational compound was associated with a reduction in gastrointestinal symptoms arising after colonoscopy, suggesting potential benefit in this setting. These findings pose a rationale for controlled prospective studies to confirm such evidence in broader clinical settings. Full article

Granular jamming grippers have emerged as a versatile solution in soft robotics due to their ability to manipulate objects of various shapes and sizes, earning them the label of “universal grippers”. They are composed of granular material confined within an elastic membrane that conforms to the object like a fluid and solidifies upon vacuum application, enabling a firm grip through friction and grain interlocking. This work provides a systematic review of the state of the art, addressing their physical principles, the influence of grain and membrane properties, performance characterization methods, and applications across diverse fields. Additionally, the main control variables of these grippers closely related to state variables used in control systems are discussed, along with the current knowledge gaps. Finally, five potential directions for future research are proposed. Full article

Objectives: To compare the feasibility and image quality of a post-contrast free-breathing radial stack-of-stars 3D T1w turbo-field echo Dixon sequence (3D T1w VANE mDIXON) with a conventional cartesian breath-hold 3D T1w fast-field echo mDIXON sequence in pediatric oncology patients undergoing chest MRI. Methods: A total of 48 children (34 females; mean age 5.3 ± 3.7 years) underwent contrast-enhanced chest MRI, with 24 examined using the 3D T1w VANE mDIXON sequence and 24 with a conventional breath-hold 3D T1w mDIXON sequence. Image quality was independently assessed by three radiologists using a 5-point scale. Signal-to-noise ratio (SNR) was measured at two anatomical sites, a homogeneous paraspinal muscle region (SNR_muscle) and the liver apex (SNR_liver), while avoiding vessels and signal inhomogeneities. The presence of respiratory artifacts, total imaging time, and the need for general anesthesia or sedation were recorded. Interobserver agreement was determined using Fleiss’s kappa (ϰ), and mean SNR values were compared between groups using an independent samples t-test. Results: The 3D T1w VANE mDIXON sequence yielded significantly higher SNR_muscle and SNR_liver (530 ± 120; 570 ± 110 vs. 370 ± 110; 400 ± 90; p < 0.001), improved diagnostic image quality by approximately 25%, and reduced respiratory artifacts by about 23%. Interobserver agreement was almost perfect. Importantly, the need for general anesthesia was significantly reduced using the 3D T1w VANE mDIXON (p < 0.001). Conclusions: Free-breathing 3D T1w VANE mDIXON chest MRI is a feasible and effective imaging approach for pediatric oncology patients, offering superior image quality and reducing the need for general anesthesia compared to conventional methods. Full article

Mining activities can trigger geological disasters, including slope instability and surface subsidence, posing a serious threat to the surrounding environment and miners’ safety. Consequently, the development of reasonable, effective, and rapid deformation monitoring methods in mining areas is essential. Traditional synthetic aperture radar(SAR) satellites are often limited by their revisiting period and image resolution, leading to unwrapping errors and decorrelation issues in the central mining area, which pose challenges in deformation monitoring in mining areas. In this study, persistent scatterer interferometric synthetic aperture radar (PS-InSAR) technology is used to monitor and analyze surface deformation of the Jinchuan mining area in Jinchang City, based on SAR images from the small satellites “Fucheng-1” and “Shenqi”, launched by the Tianyi Research Institute in Hunan Province, China. Notably, the dual-star constellation offers high-resolution SAR data with a spatial resolution of up to 3 m and a minimum revisit period of 4 days. We also assessed the stability of the dual-star interferometric capability, imaging quality, and time-series monitoring capability of the “Fucheng-1” and “Shenqi” satellites and performed a comparison with the time-series results from Sentinel-1A. The results show that the phase difference (SPD) and phase standard deviation (PSD) mean values for the “Fucheng-1” and “Shenqi” interferograms show improvements of 21.47% and 35.47%, respectively, compared to Sentinel-1A interferograms. Additionally, the processing results of the dual-satellite constellation exhibit spatial distribution characteristics highly consistent with those of Sentinel-1A, while demonstrating relatively better detail representation capabilities at certain measurement points. In the context of rapid deformation monitoring in mining areas, they show a higher revisit frequency and spatial resolution, demonstrating high practical value. Full article

Background/Objectives: Salmonella Infantis (S. Infantis) is a bacterium that has gained importance in public health over the last decade due to its high pathogenicity and resistance to antibiotics. Therefore, the objective of the present study was to present key considerations for the design and development of geraniol-loaded nanocapsules for its delivery in the drinking water or feed of broiler chickens and to evaluate its potential as an antimicrobial agent against S. Infantis using a standard in vitro microplate assay and a model that simulates the pH and feed conditions of the crop of broiler chickens. Methods: Using a 3^k factorial experimental design, geraniol nanocapsule-based formulations were selected, and their antimicrobial activity was evaluated in in vitro models. Results: The results demonstrated that geraniol alone exhibits antimicrobial action against S. Infantis mainly due to its lipophilicity, hydrophobicity and the presence of the hydroxyl group found in its chemical structure, but when formulated in nanocapsular systems, the interaction of its components tends to reduce its antimicrobial action, especially the mixture of Tween 80:Span 80 and Miglyol^® 810N. Furthermore, the use of the in vitro model that simulates the crop of broiler chickens demonstrated that the formulation also has interactions with the feed components, completely nullifying the antimicrobial action of geraniol compared to that obtained in the in vitro microplate model. Conclusions: Preformulation studies during the development of nanocapsule-based formulations should be considered for the correct selection of the components of a formulation to ensure its effectiveness, without only considering the physicochemical and stability properties of these as is frequently seen in studies. Full article

Previous research has shown individual differences in (a) time on task (ToT) and (b) the degree of structuredness in processing figural matrices. The goal of this article was to integrate these two lines of research by analyzing log files from a computer-based assessment (N = 198) to examine the role of three ToT sub-components: onset times (before engaging with the first matrix rule), interrule times (between the rules), and intrarule times (within a single rule). We tested three clues that support the assumptions that the interrule times reflect the cognitive construction of a rule-specific solution plan, while the onset times represent a global orientation reaction, and the intrarule times capture the behavioral execution of the plan: (1) based on the interrule times, we identified two clusters of participants, of which one processed the matrices in a more structured fashion; (2) only the accelerating effect of the interrule times across the test was associated with test performance, indicating higher reasoning saturation; (3) a mediated path analysis revealed that faster interrule times propagate in faster intrarule times and more structured processing of matrix rules, resulting in better performance. Confirming internal validity, the three log file times accounted for an incremental 24.30% of test performance variance beyond the traditional ToT. Confirming external validity, two clusters were also identified based on the interrule times from the first test and performance scores from a second matrix test. Full article

Cold spray (CS) uses high-velocity gas to deposit solid particles without oxidation or phase change. To make the spraying process more economical, a wider-sized cut of feedstock particles needs to be deposited. The liquid cold spray (LCS) process, which uses water as a propellant, has been developed to achieve this goal. The use of water as a propellant may adversely affect particle deformation and adhesion. In this study, numerical methods are used to analyze particle and substrate oxide failure to determine the effects of wetting on particle adhesion to a substrate. The results indicate that water on the particle surface or on substrate would reduce the deformation of both. The area in which oxide layers fail and metallurgical bonding can occur would be reduced. A portion of the water may become entrapped between the particle and the substrate, adversely affecting the bonding area. Increasing particle velocity and decreasing water thickness can reduce the volume of trapped water and improve density by increasing particle deformation and decreasing pore size. Full article

Xyloglucan from Tamarindus indica seeds (TISs) is a polysaccharide widely used in the food, biomedical, and pharmaceutical sectors. Nevertheless, the challenge in future research for the food processing industry is to provide adequate knowledge regarding natural product extraction, chemical modifications, interactions, and potential applications according to sustainability issues. The goal of this work was to implement a sustainable method for xyloglucan extraction from TISs at a semi-industrial scale and carry out the characterization of this hydrocolloid, to compare the effect of the technique of decorticating of seeds on the chemical composition and physicochemical properties of xyloglucan. The TISs were decorticated using soaking (DS) and roasting (DR) methods, and, then, the xyloglucan was extracted applying a semi-industrial mechanical separation process. Subsequently, the extraction yield, chemical content, Fourier transform infrared analysis, color, morphology, molecular weight (MW), viscosity, texture, Z potential, particle size, and thermal properties were evaluated. Xyloglucan extraction from TISs at a semi-industrial scale was demonstrated for the first time. The xyloglucan yield by DR (44.04%) was significantly higher (p < 0.05) compared with DS (41.42%), while separation efficiency was similar in both methods (~97%). Significant differences (p < 0.05) in fat, ashes, crude fiber, calcium, total phenolic content, and antioxidant capacity in xyloglucan samples were observed by applying DS and DR. The method of decorticating promoted changes in the MW and particle size of xyloglucan samples, which were reflected in the viscosity, particle size, texture attributes, Z potential, and thermal properties of xyloglucan. These results show that the decorticating method is an important issue to be considered in the resultant chemical and physicochemical properties of xyloglucan extracted from tamarind seeds, for suitable applications of the xyloglucan in the food processing and pharmaceutical industries. Full article

This paper addresses the design, analysis, and validation of safe close-proximity operations around uncooperative targets, with an application to the ClearSpace-1 (CS-1) mission. It is focused on the areas of Guidance, Navigation, and Control (GNC), and Mission Analysis, due to their criticality for the success and safety of this kind of operation. The relevance of the concepts, of the GNC solutions, and their validation is demonstrated for the case study of CS-1, a reference mission for the rendezvous, capture, and de-orbiting of an uncooperative target (i.e., the VESPA payload adapter). It is shown how the design approach can be adopted for the Concept of Operations of CS-1, covering the definition of keep-out zones, corridors, and GO/NO GO criteria, for assessing the passive safety of trajectories, and for the incorporation of active safety strategies. The analysis is adopted for functional chains such as the Navigation and Control, and the combination of a prototyping and a high-fidelity simulator is adopted for directed Model-in-the-Loop Monte-Carlo campaigns. The outcomes are intended to support the industry in the development of Close-Proximity Operations similar to that of CS-1. These can be adopted in a wide variety of missions, including Active Debris Removal and In-Orbit Servicing. In particular, the adopted concepts are a key contribution to the standardization of Close-Proximity Operations for non-cooperative rendezvous missions, and act towards a sustainable and safe commercial application. Full article

In this work, combined efforts by Greek and Turkish scientists produced an updated validated NIS inventory of the Aegean ecoregion, covering 120 years of records up to August 2024. Of the 342 NIS currently present in the Aegean Sea, the majority (281 species) have invaded the South Aegean, followed by the North Aegean (128 species out of 206 NIS). A total of 73 species were added to the list, while 56 were removed. Overall, unaided spread of Lessepsian immigrants from the Levantine Sea and shipping are equally responsible for NIS reported at the regional level. An increase in publications addressing NIS matches the upward trend of NIS since the mid-1990s, which continues to the present day. While unaided introductions of Lessepsian species and/or direct introductions via the Suez Canal peaked in the South Aegean during 2000–2005, they peaked in 2012–2017 in the North Aegean—a decade later. The opposite pattern was observed in ship-transferred NIS. The spatial distribution of introduction hotspots largely reflects the following phenomena/processes: unaided introduction is witnessed initially in the southeastern Aegean Sea; monitoring efforts are concentrated in vulnerable and at-risk areas; and research efforts relate to the spatial allocation of institutions and marine experts working on marine NIS along the Aegean coasts. Full article