Search Results (33,789)

Plantain (Musa paradisiaca) peel is an agro-industrial waste product with remarkable functional potential, attributed to its composition of bioactive compounds with antioxidant and antimicrobial properties. Given this scenario, this scoping review aimed to map and synthesize the scientific evidence regarding the nutritional composition and potential functionalities of plantain peel. A scoping review approach was used, and data were reported using the PRISMA-ScR checklist. The studies evaluating the use of plantain peel were included without restrictions on language or publication date. The following databases were searched: Embase, MEDLINE (via PubMed), Scopus, and Web of Science. Additional searches were conducted through Google Scholar. The protocol has been registered prospectively on the Open Science Framework. This review’s findings included 53 studies. All of them presented methodological limitations that hindered further analysis and the generation of robust evidence. This analysis detailed the chemical composition of the peel, showing that it varies with ripeness stage and processing and is an excellent source of fiber and minerals. Several technological applications are explored, including the use of peel in the production of functional foods, the development of nanoparticles with antimicrobial activity, and its use as a substrate for the biosynthesis of industrial enzymes and citric acid. This review also addresses the possible health benefits that have already been studied in animal and in vitro models. Plantain peel is a promising agro-industrial by-product with high fiber, starch, and bioactive compound content and functional properties. Despite advances, challenges in sensory acceptance and process standardization limit industrial application. A key research gap remains in the systematic evaluation of antinutrient reduction (e.g., oxalates, phytates) and pesticide residue levels during the processing of plantain peel, a mandatory step before its widespread application in the food industry (e.g., flours and food additives). Further research on optimization and bioactive mechanisms is essential to enable its large-scale use and strengthen its role in the circular bioeconomy and human health. Full article

The 2022 Chongqing wildfires, occurring during an unprecedented heatwave, severely degraded subtropical forest ecosystems and disrupted hydrological cycling. We developed an integrated artificial intelligence framework combining Long Short-Term Memory and Transformer architectures to simulate post-fire evapotranspiration (ET) dynamics using 37 months of field observations (2022–2025) across 24 plots with four burn severities. The Penman–Monteith–Leuning model provided physically based benchmarks. Results revealed three distinct recovery phases: destruction/stagnation (0–7 months, ET at 6%–10% of pre-fire levels), rapid recovery (8–19 months), and stabilization (20–37 months, reaching 100% ET recovery). The coupled LSTM–Transformer ensemble achieved superior performance (RMSE = 0.10 mm·day⁻¹, NSE = 0.98), outperforming single models by 31% in uncertainty reduction. SHAP analysis identified phase-dependent factor shifts: soil water content dominated Stage I (42.5%), while leaf area index (LAI) controlled Stages II–III (>48%). A bimodal LAI time-lag effect emerged: 4–7 days (leaf water potential equilibrium, 27.7% contribution) and 8–14 days (root uptake compensation, 21.7%). Burn severity significantly extended time-lags (severe burns: 12/21 days vs. unburned: 5/12 days), indicating hydraulic system reconstruction requirements. Despite equivalent LAI recovery, severe burns maintained 12%–15% ET reduction, suggesting lasting hydraulic limitations. This study demonstrates that physics-constrained AI models effectively capture complex post-fire ecohydrological dynamics while providing mechanistic interpretability, advancing understanding of vegetation–water coupling reconstruction under increasing fire frequency. Full article

Melissopalynological analysis is essential for determining the botanical origin of honey, corbicular pollen and bee bread, as well as detecting adulteration. However, it traditionally relies on labor-intensive and subjective manual pollen identification. As a proof-of-concept preceding full honey analysis, this study evaluates artificial intelligence methods for automated pollen grain recognition under controlled conditions. Hazel (Corylus avellana L.) and dandelion (Taraxacum officinale F.H. Wigg.) were used as model taxa to validate the proposed approach before its application to real varietal honey samples. This study introduces a novel three-stage pipeline that decouples object detection from feature extraction, utilizing YOLOv12m for region-of-interest generation and, for the first time in melissopalynology, DINOv3 ConvNeXt-B for deep feature representation. Microscopic images acquired at 400× magnification yielded 2498 dandelion and 1941 hazel pollen grains. The detector achieved an mAP@0.5 of 0.936 with an F1 score of 0.88, while the classifier reached 98.1% accuracy with good class separability (Silhouette coefficient: 0.407). The primary technical contribution is the systematic optimization of the detection-to-classification interface. Context-aware bounding box expansion (12%) and an optimized IoU-NMS threshold (0.65) significantly improve the stability of morphological feature extraction, as confirmed by ablation studies. Computational cost reporting further supports reproducible, deployment-oriented comparison. The results confirm the feasibility of this AI-based framework as an intermediate step toward automated melissopalynological analysis, with future work focusing on standardized microscopy protocols and expanded pollen databases for varietal honey authentication. Full article

Background: Freezing of gait (FoG) is a common symptom of Parkinson’s disease, especially in its later stages of progression. Characterized by involuntary stopping during normal gait patterns, FoG greatly increases fall risk, reducing quality of life. Given the complex presentation and etiology of FoG, current treatments have proven ineffective in managing episodes. In recent years, machine learning algorithms have been leveraged to derive actionable clinical insights from biomedical datasets. As a manifestation of neuromechanical dysfunction, impending FoG episodes may be characterized through data collected by wearable devices and sensors. Objective: This scoping review evaluates the current landscape of machine and deep learning-derived biomarkers to enhance the personalized management of FoG. Methods: This scoping review was conducted using established methodological frameworks for scoping reviews and is reported in accordance using the PRISMA-ScR checklist. Three databases were queried, with screening yielding 60 studies. Results: Thirty-nine papers reported on deep learning techniques, with the most common architectures being convolutional neural networks and long short-term memory models. Conclusions: Inertial measurement units, which can be worn on various locations, may be a promising modality for practical implementation. To generate closed-loop FoG therapies, algorithms can be integrated into real-time systems like robotic exoskeletons or adaptive deep brain stimulation. Future work in generating datasets from ambulatory devices, as well as distributed computing strategies, may lead to real-time FoG management. Full article

Volatile organic compounds (VOCs, dominated by xylene, toluene, and benzene) and paint mist emissions from ship painting represent a major environmental and health concern, posing a critical bottleneck to the green transformation of the shipbuilding industry. To tackle this challenge, this study presents an integrated recovery system designed specifically for ship automatic-spraying robots. Guided by the synergistic principle of “air-curtain containment, multi-stage adsorption, and negative-pressure recovery,” the system features a modular design that ensures full compatibility with the robots’ spraying trajectory without operational interference. Core adsorption materials, namely glass fiber filter cotton and honeycomb activated carbon fiber, were selected to suit the high-humidity and high-pollutant-concentration environment typical of ship painting. An appropriately matched axial flow fan maintains stable negative pressure throughout the system. Furthermore, the design integrates an air curtain isolation subsystem and an automated control subsystem, enabling coordinated operation and real-time adjustment. Using ANSYS Fluent, geometric and flow field simulation models were established to analyze airflow distribution and pollutant adsorption behavior, which led to the optimization of key structural and material parameters. Field experiments conducted in shipyard environments demonstrated the system’s superior performance: it achieved a VOC removal efficiency of 88.4% and a paint mist capture efficiency of 85.7% under optimal working conditions, with a maximum simulated paint mist capture efficiency of 86.2%. The system maintained stable performance under complex vertical and overhead spraying conditions, with an efficiency attenuation of less than 1.5%, and its outlet emissions fully complied with the mandatory limits specified in the Emission Standard of Air Pollutants for the Shipbuilding Industry (GB 30981.2-2025). The relative error between experimental data and simulation results is less than 2%, confirming the reliability and practicality of the proposed system. This research provides an efficient and adaptable pollution control solution for green shipbuilding and offers valuable technical insights for the sustainable upgrading of automated painting processes in heavy industries. Full article

Objective: To evaluate the utility of synovial iron quantification using Magnetic resonance imaging (MRI) in assessing structural joint damage in the knee of patients with rheumatoid arthritis (RA). Methods: This cross-sectional study employed a two-stage design. In the initial comparative stage, 6 patients with RA and 5 patients with osteoarthritis (OA) were recruited to compare synovial R2* values, a metric derived from iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation (IDEAL-IQ) MRI sequences representing synovial iron content. Following this, the RA cohort was expanded to a total of 51 patients to investigate the association between R2* values and clinical parameters, including disease activity and bone erosion. Synovial fluid iron levels were measured with an Iron Assay Kit and synovial iron deposits were semi-quantified via Prussian blue staining. Associations between R2* and clinical and laboratory parameters, including inflammatory factors and joint damage indices, were analyzed using Spearman’s rank correlation. Univariate and multivariate ordered logistic regression models were employed to identify factors associated with bone erosion severity. An R2*-based nomogram was developed and validated using receiver operating characteristic (ROC) analysis and calibration curves. Results: Synovial R2* values were significantly higher in RA patients than those with osteoarthritis (53.66 S⁻¹ vs. 31.38 S⁻¹, p < 0.05), consistent with Prussian blue staining results. While synovial R2* values showed no significant correlation with systemic iron metabolic markers, inflammatory indicators, or the Disease Activity Score 28, they were positively correlated with bone erosion severity (ρ = 0.500, p < 0.001) and negatively associated with the joint space width (ρ = −0.307, p < 0.05). Multivariate analysis identified R2* as an independent indicator linked to bone erosion extent (OR = 2358.336, p < 0.001). The R2*-based nomogram demonstrated good discriminative performance. (AUC = 0.83). Conclusions: The R2* value derived from IDEAL-IQ MRI is a reliable tool for quantifying synovial iron and may represent a promising non-invasive imaging biomarker reflecting bone erosion in RA patients. Full article

An analytical model of frictional heat transfer during the uniform sliding of two layers is proposed. One layer is composed of a functionally graded material (FGM) with a thermal conductivity coefficient that varies exponentially across its thickness, while the second layer is homogeneous, with constant thermophysical properties. The thermal problem of friction is formulated as an initial boundary value problem of heat conduction, accounting for the thermal contact conductance and convective heat exchange with the environment. An exact solution for constant friction power was obtained using the Laplace integral transform, supplemented by an asymptotic form for the initial stage of heating. Based on these analytical solutions, a comprehensive study was carried out for a frictional system comprising a ceramic–metal FGM composite in contact with a homogeneous friction material. A dimensional analysis allowed for both a qualitative and quantitative investigation into the influence of contact conductance, convective heat exchange, layer thickness and the FGM gradient parameter on the temperature evolution and distribution, as well as the time to reach the steady state. It was demonstrated that the implementation of an appropriately graded material can substantially improve thermal operating conditions by enhancing heat dissipation into the material bulk and intensifying convective cooling. Full article

Medium-term 5G/NB-IoT planning is made difficult by simultaneous uncertainty in device adoption and per-device traffic behavior because deterministic point forecasts do not quantify overload risk or support reliability-based capacity decisions. A diffusion-to-dimensioning workflow is proposed in which S-curve adoption modeling, bounded usage priors, scenario stress testing, and Monte Carlo uncertainty propagation are combined to generate predictive demand distributions, exceedance curves, and quantile-based capacity rules. The framework is applied to a Great Britain case study for 2025–2029 using smart meter deployment data and an M2M-based proxy for asset-tracking adoption. Analysis shows that planning-year upper-tail outcomes are driven primarily by asset-tracking usage uncertainty rather than by proxy scale alone. A ±30% perturbation of the AT adoption anchor changes $Q_{0.95}$ by approximately ±29.8%, whereas stressed AT usage increases $Q_{0.95}$ by 74.4%. Plausible positive dependence among key AT operational inputs further raises $Q_{0.95}$ by 18.3–22.5%. Limited hold-out evaluation provides strong out-of-sample support for the smart meter adoption stage and plausibility-only support for the shorter AT proxy. The framework is intended for medium-term, data-lean planning settings and is designed to support transparent risk-based capacity decisions rather than deterministic point sizing. Full article

Background: Predicting genomic alterations from routine hematoxylin and eosin (H&E) whole-slide images (WSIs) may help triage molecular testing. Methods: We retrospectively enrolled 437 patients at Osaka Metropolitan University Hospital across 26 cancers, matched with clinical gene-panel data. We curated 1023 binary endpoints across SNV, CNV, and SV categories. We extracted slide embeddings from five pathology foundation models (Prism, GigaPath, Feather, Chief, and Titan) using a unified feature extraction pipeline and benchmarked them using a lightweight downstream Multi-Layer Perceptron (MLP) classifier. Using the best-performing patch feature system, we trained a multi-instance learning model to assess incremental benefit. Results: Titan achieved the highest and most stable transfer performance, with a median endpoint-wise Area Under the Receiver Operating Characteristic curve (AUROC) of 0.77 in the slide benchmarking; at the patch-level, prediction of APC_SNV reached an AUROC of 0.916, and prediction of KRAS_SNV reached an AUROC of 0.811 on the held-out test set. Conclusions: In a heterogeneous clinical gene-panel setting, pathology foundation models can provide strong baseline genomic-prediction signals without additional fine-tuning. We propose a practical, deployment-oriented two-stage workflow: rapid slide-embedding screening to prioritize robust representations and candidate endpoints, followed by patch-level training for high-value tasks where additional performance gains and interpretable regions are clinically worthwhile. Full article

Accurate and timely cotton-field mapping is essential for irrigation management, water resource allocation, and regional yield assessment in arid irrigated agroecosystems. However, existing deep-learning-based crop mapping approaches generally lack interpretability and often exhibit performance variability across phenological stages, thereby limiting their reliability for operational deployment. To address these limitations, we developed an interpretable semantic segmentation framework for cotton mapping in the Wei-Ku Oasis, Xinjiang, China, under multi-source remote sensing conditions. The proposed model integrates Sentinel-2 surface reflectance, Sentinel-1 VV/VH backscatter, DEM, vegetation indices, and GLCM texture features. By incorporating a receptive-field enhancement mechanism together with an embedded feature-attribution module, the framework enables importance estimation of multi-source predictors within the network architecture, thereby providing intrinsic model interpretability. Under a unified training and evaluation protocol, the proposed model achieved an mIoU of 85.62% and an F1-score of 92.96% on the test set, outperforming U-Net, DeepLabV3+, and SegFormer baselines. Monthly classification results indicated that August provided the most discriminative acquisition window (mIoU = 85.54%, F1 = 92.83%), while June–July also maintained high recognition accuracy. Feature attribution results indicate that the importance of different predictors varies across phenological stages: Sentinel-2 red-edge bands remained highly influential throughout the growing season, NDVI/EVI exhibited increased contributions during June–August, SAR VH showed relatively higher importance during peak canopy development, and DEM maintained stable information contribution across all stages. Cross-year and cross-region experiments further demonstrated the model’s generalization capability, achieving an mIoU of 82.81% in same-region cross-year evaluation and 74.56% under cross-region transfer. Overall, the proposed segmentation framework improves classification accuracy while explicitly modeling and quantifying feature importance, providing a methodological reference for cotton-field mapping and acquisition timing selection in arid irrigated regions. Full article

Cardiovascular-kidney-metabolic (CKM) syndrome integrates excess adiposity, metabolic dysfunction, kidney impairment, subclinical cardiovascular diseases, and clinical events along a staged continuum that invites unified prevention and treatment. Ultra-processed foods (UPFs) are a complex, high-prevalence exposure that may influence risk across CKM stages through nutrient profiles, additives, processing-induced compounds, and packaging-related contaminants. This review synthesizes epidemiologic, mechanistic, and translational evidence with attention to exposure definition and analytic rigor. We summarize NOVA-based UPF operationalization across dietary assessment tools, highlighting misclassification of mixed dishes, brand heterogeneity, and energy under-reporting, and we propose further examination of energy-adjusted models, calibration, and harmonized metrics. Observational studies consistently associate higher UPF intake with adiposity, diabetes, chronic kidney disease, cardiovascular events, and mortality, with modest to moderate effect sizes that are heterogeneous across populations. Mechanistic data from metabolomics, lipidomics, proteomics, and the gut microbiome converge on pathways of inflammation, lipid metabolism, oxidative and metabolic stress, and intestinal barrier dysfunction; in selected cohorts, multi-omics modules account for a substantial minority of UPF-outcome associations. We outline quality-control pipelines, batch-effect prevention/correction, and multiple-testing control necessary for reproducible diet-omics. Translationally, targeted lipidomic and proteomic panels show promise for CKM risk stratification and monitoring but require validation, clinical thresholds, and guideline endorsement. Equity and global context, including differences in product mix, food systems, and care capacity, modify population impact. We conclude with a research agenda prioritizing harmonized exposure metrics, error-aware modeling, standardized multi-omics workflows, and adequately powered, stage-specific interventions capable of testing mediation and prognostic utility. Full article

Objective: This study aimed to evaluate the prognostic significance of lymphocyte-associated inflammatory markers and the HALP score in patients with Hodgkin’s lymphoma. Methods: This was a retrospective study that included patients who were diagnosed with Hodgkin’s lymphoma and followed up between 2004 and 2024. The inflammatory markers (NLR, PLR, MLR, SII, SIRI, and PIV) and HALP score were calculated from the patients’ biochemical and hematological parameters, and the relationship between these parameters and stage, spleen and liver involvement, relapse, mortality, overall survival, and progression-free survival was analyzed. Results: A total of 117 patients were included, and multivariate analysis indicated that progression-free survival was statistically and significantly associated with treatment type (p = 0.0285), PLR (p = 0.0188), and PIV (p = 0.0297). In terms of overall survival, age (p = 0.0011), treatment type (p = 0.0108), and SIRI (p = 0.0108) remained as statistically significant predictors. Although the HALP score showed a significant association with PFS in the univariate analysis (p = 0.0104), this association did not persist in the multivariate model. In addition, no statistically significant relationship between the HALP score and OS was observed in either the univariate or multivariate analysis. Conclusions: The SIRI is a prognostic marker in Hodgkin’s lymphoma and may be useful for predicting overall survival. Full article

Live case studies are widely used in higher education to support active learning; however, their pedagogical potential is often limited by weak integration with learning theories and assessments. This research-to-practice study examines the systematic design of live case studies by integrating Kolb’s experiential learning cycle (ELC) and authentic assessment (AA) principles. This paper presents a framework that conceptualises live cases as the learning context, ELC as the learning process, and AA as evaluative logic. The framework is illustrated through a case study of an undergraduate Quality Management module in industrial engineering at a Mexican university, involving 31 final-year students. The study is design-oriented and illustrative, aiming to demonstrate framework enactment rather than evaluating causal effectiveness. Using a case study methodology, the instructional design and enactment were documented using the ADDIE model. Data were obtained from educational artefacts, assessment results, and student feedback surveys. The findings suggest that aligning teaching and assessment activities with the ELC stages and the AA principles effectively supports learning trajectories. This support covers experience, reflection, conceptualisation, and application. Live case studies enabled the integration of multiple assessment methods around shared organisational problems and supported personalised learning through students’ case selection. This study contributes a design logic and operational framework for distributing authentic assessment across Kolb’s experiential learning stages within live case pedagogy. Rather than offering statistical generalisation, the framework serves as a foundation for adaptation and research, emphasising transferability across disciplines, educational levels, and delivery modes. Limitations are acknowledged regarding the conceptual scope, methodological design, and empirical context. Full article

The complex architecture and stacking patterns of deepwater turbidite channel sandbodies introduce significant uncertainty in injector–producer connectivity. This uncertainty affects both the mechanisms and the quantitative evaluation of the waterflood sweep. In this study, a representative reservoir in the Niger Delta Basin is selected as a case study. Injector–producer well groups are first classified into three connectivity patterns—coeval, cross-stage, and hybrid based on geological and seismic constraints. Time-lapse seismic data are then interpreted to delineate sweep morphology and to infer the controlling mechanisms associated with each pattern. Coeval connectivity exhibits a relatively uniform and continuous front advance with minimal barriers. Cross-stage connectivity shows fragmented swept regions with pronounced bypassing, and localized preferential breakthrough caused by discontinuous sandbodies and pervasive barriers. Hybrid connectivity is characterized by intermediate behavior, combining features of both patterns. To translate these mechanistic differences into quantitative metrics for development evaluation, an oil–water relative permeability ratio correlation for low viscosity oil is established that remains valid across the full water cut range, thereby overcoming the limitations of conventional semi-log linear correlations at both low and ultra-high water cut stages. Based on this framework, a production data-driven predictive model for waterflood sweep efficiency is derived using production data and steady state flow theory. The model is validated across well groups representing different connectivity patterns. Field application yields a consistent ranking of sweep efficiency: coeval > hybrid > cross-stage, with group average values of 0.86, 0.80, and 0.70, respectively. These results agree with the mechanistic interpretation derived from time-lapse seismic analysis. The proposed methodology provides a practical quantitative framework for evaluating injector–producer connectivity and comparing development strategies in deepwater turbidite channel reservoirs. Full article

Background: Many SCOR performance measures rely on internal operational data, which limits empirical work using public information. Methods: This study evaluates a small set of publicly auditable, SCOR-linked ratios (SCOR_E) in a panel of 12 publicly traded firms across four sectors from 2000 to 2022. Using firm- and year-fixed-effects panel models, the paper examines whether these candidate proxies show pre-specified directional associations within firms and whether the same ratios are associated with operating margin in parallel models. Instrumental-variable (IV) specifications are reported only as sensitivity analyses, and nearly all are weak by the paper’s reported first-stage diagnostics. Results: Accordingly, most findings are interpreted as associative rather than causal. After false-discovery-rate adjustment and weak-instrument-robust inference, only four firm–proxy pairs meet the paper’s detection criterion; all remaining estimates are treated as non-robust. Conclusions: The contribution is therefore narrow: this is a constrained exploratory screening exercise showing which candidate mappings survive the paper’s inferential filters in this sample and which do not. The results do not establish a validated cross-industry scorecard, a scalable benchmarking framework, or a basis for policy claims. Full article