Search Results (53)

Objective: The aim of this study was to analyse the evolution of heart rate variability (HRV) during official competition in high-level amateur padel players according to match outcome. Methods: HRV was measured in 44 individual recordings obtained across 11 matches involving 12 padel players. Measurements were taken before the match (PRE), during three sets (S1, S2 and S3) and during the two rest periods between sets (R1 and R2). Time-domain variables analysed included mean R–R interval (Mean RR), standard deviation of normalised R–R intervals (SDNN), root mean square of successive differences (RMSSD), natural logarithm of RMSSD (LnRMSSD) and standard deviation of heart rate (STD HR), while nonlinear variables included the transverse (SD1) and longitudinal (SD2) axes of the Poincare plot, stress score (SS) and the sympathetic–parasympathetic ratio (SNS/PNS ratio). Results: Significant fluctuations in HRV were observed throughout the match. Players who won exhibited significantly higher values of Mean RR, SDNN, RMSSD, LnRMSSD, SD1 and SD2 during S1 (p < 0.05), and higher Mean RR, RMSSD, LnRMSSD and SD1 during R1 (p < 0.01). These differences diminished as the match progressed, disappearing in the later phases (S3, R2). Temporal analysis revealed that both groups showed parasympathetic recovery during the rest periods. Conclusions: This study provides novel evidence on the temporal dynamics of autonomic regulation in padel, showing that match outcome is associated with differences in cardiovascular regulation during the initial phases of competition. These findings support the usefulness of HRV monitoring for performance management in real competition settings. Full article

Background: Passing in lacrosse is a fundamental skill essential for both offense and defense, directly influencing game flow. Although the speed–accuracy trade-off is well recognized in motor control, its features in lacrosse passing—particularly regarding directional aspects and skill differences—remain unclear. This study quantified the relationship between pass speed, accuracy, bias, and consistency and examined directional effects and skill-level differences. Methods: Twenty-two female university players (skilled: n = 9; unskilled: n = 13) executed overhand passes to a 5 cm × 5 cm target from 11 m under three effort conditions: warm-up, game intensity, and full effort. Ball speed was derived from lateral video, and landing coordinates from posterior footage. Accuracy, bias, and consistency were assessed using radial error (RE), centroid error (CE), absolute CE (|CE|), and bivariate variable error (BVE). Directional patterns were analyzed through lateral and vertical components and the 95% confidence intervals of the major and minor axes of an error ellipse. A two-way analysis of variance was performed with condition as the within-subject factor and skill level as the between-subject factor. Results: Ball speed increased significantly across conditions. RE, |CE|, and BVE increased with speed, showing directional dependence: variability expanded mainly along the major axis, while the minor axis remained stable. Skilled players showed smaller RE and BVE, with differences most evident vertically and along the major axis. CE direction stayed consistent, indicating that reduced accuracy stemmed from greater bias magnitude and lower consistency rather than shifts in the mean landing point. Conclusions: Findings confirm a speed–accuracy trade-off in lacrosse passing, characterized by directional specificity and skill-related effects. Combining RE, CE, BVE, and ellipse-axis analyses clarified error structure, showing variability concentrated along the movement axis. These results support training focused on vertical control and timing and highlight the value of directional metrics for assessing lacrosse performance. Future research should include male athletes, advanced levels, and in-game scenarios to extend generalizability. Full article

Three-dimensional (3D) printing enables accurate implant pre-shaping in orbital reconstruction but is costly and time-consuming. Naked-eye stereoscopic displays (NEDs) enable virtual implant modeling without fabrication. This study aimed to compare the reproducibility and accuracy of NED-based virtual reality (VR) pre-shaping with conventional 3D-printed models. Two surgeons pre-shaped implants for 11 unilateral orbital floor fractures using both 3D-printed and NED-based VR models with identical computed tomography data. The depth, area, and axis dimensions were measured, and reproducibility and agreement were assessed using intraclass correlation coefficients (ICCs), Bland–Altman analysis, and shape similarity metrics—Hausdorff distance (HD) and root mean square error (RMSE). Intra-rater ICCs were ≥0.80 for all parameters except depth in the VR model. The HD and RMSE reveal no significant differences between 3D (2.64 ± 0.85 mm; 1.02 ± 0.42 mm) and VR (3.14 ± 1.18 mm; 1.24 ± 0.53 mm). Inter-rater ICCs were ≥0.80 for the area and axes in both modalities, while depth remained low. Between modalities, no significant differences were found; HD and RMSE were 2.95 ± 0.94 mm and 1.28 ± 0.49 mm. The NED-based VR pre-shaping achieved reproducibility and dimensional agreement comparable to 3D printing, suggesting a feasible cost- and time-efficient alternative for orbital reconstruction. These preliminary findings suggest that NED-based preshaping may be feasible; however, larger studies are required to confirm whether VR can achieve performance comparable to 3D-printed models. Full article

This study was conducted based on hybrid damping control theory, and an equivalent damping ratio calculation method was proposed. Additionally, a response calculation method for the elastoplastic stage of the hybrid control system was developed. Furthermore, a cooperative working mechanism between viscous dampers and metal composite dampers was introduced. A time–history analysis was employed to verify the system’s effectiveness in optimizing the multi-dimensional seismic performance of frame structures. Using actual engineering as the research background, an elastoplastic analysis of the hybrid control system was conducted. The analysis results show that the first three natural periods of vibration were shortened by 6.1% (in the X direction), 5.9% (in the Y direction), and 21.0% (torsion), effectively enhancing the overall stiffness of the structure. Under seismic action, the inter-story displacement decreased by 37.1% to 0.166 m in the X direction and by 48.3% to 0.080 m in the Y direction; the base shear forces were reduced by 58.8% (in the X direction) and 41.7% (in the Y direction). Regarding damage control, the number of plastic hinges was significantly reduced, and they appeared only on the most unfavorable floors; the axial compressive stress peaks in the frame columns were strictly controlled below 0.65 fc, and the inter-story displacement angles (<1/50) met the standards of GB50011-2010 for key protection structures. The hybrid system demonstrated multi-dimensional synergistic effects, whereby the viscous dampers primarily controlled the acceleration responses in the X direction, while the metal composite dampers dominated energy dissipation in Y displacement. The difference in seismic reduction efficiency between the two main axes was less than 11%, and a 21% improvement in the torsional period was achieved simultaneously. Full article

Background/Objectives: The prevalence of inflammatory bowel disease (IBD) in spondyloarthritis (SpA) patients is unknown. Our objective was to assess the prevalence of undiagnosed IBD in SpA patients, including those with axial spondylarthritis (axSpA) or psoriatic arthritis (PsA). Additionally, we examined fecal calprotectin (FC) levels in relation to the accuracy of IBD diagnosis. Methods: EISER was a cross-sectional, multicenter, observational, rheumatologist–gastroenterologist collaborative study. Patients with SpA naïve to biologics were recruited. Demographic and clinical characteristics, disease activity, and treatment information were collected. Patients with FC ≥ 80 µg/g or IBD-related symptoms underwent a colonoscopy or video capsule endoscopy. Receiver operating characteristic analysis assessed the predictive value of FC for IBD diagnosis. Results: Of the 570 patients recruited, 494 were evaluable for the main outcome, 248 (50.2%) had axSpA, and 246 (49.8%) had PsA. Overall, 28/494 patients were diagnosed with IBD (5.7%, 95%CI 3.6–7.7). Sorted by clinical entity, 22 (8.9%, 95%CI 5.3–12.4) axSpA and 6 (2.4%, 95%CI 0.5–4.4) PsA patients had a diagnosis of IBD: 24 (86%, 95%CI 79.4–92.6) had ileal/ileocolonic Crohn’s disease (CD), 3 (11%, 95%CI 5.1–16.9) unclassified IBD, and 1 (3.5%, 95%CI 0.0–6.9) ulcerative colitis. The ROC curve for FC and IBD diagnosis (AUC: 0.870, p < 0.001, 95%CI 83.7–89.8) showed that an FC ≥ 147 µg/g had a positive predictive value of 17.4% (95%CI 14.5–20.8) Conclusions: In SpA, the prevalence of undiagnosed IBD was 5.7%, higher in axSpA (8.9%) than in PsA (2.4%) patients, with CD being the most common. SpA patients with FC levels < 147 µg/g had a very low probability of IBD. Full article

Lithium-ion battery lifetime prediction traditionally relies on extensive full-cycle testing, which is costly and time-consuming. This paper proposes a novel framework for strategic sample optimization that significantly reduces testing requirements while preserving the ability to capture key degradation patterns. The approach combines combinatorial analysis with model-informed selection to identify a minimal yet representative subset of test conditions that span the primary stress axes, temperature, depth of discharge, and charge rate. A recent predictive modeling technique is then used to validate that the selected samples enable accurate lifetime estimation. Results demonstrate that as few as 3 samples (11% of the original 27-sample dataset) can achieve prediction errors below 2%, reducing cycling costs by approximately 90%. This framework offers a scalable solution for battery developers seeking to streamline accelerated aging protocols. Future work will extend the methodology to additional publicly available datasets to assess its generalizability across chemistries and use cases. Full article

The full chemical shift tensor of ²⁰⁷Pb (spin $I=1/2$) in the natural mineral crocoite, PbCrO₄, has been determined using single-crystal NMR spectroscopy at room temperature. The eigenvalues of the tensor in its principal axes system are ${\delta }_{11}=-2720\pm 2$ ppm, ${\delta }_{22}=-2319\pm 4$ ppm, and ${\delta }_{33}=-1830\pm 5$ ppm, resulting in an isotropic chemical shift of ${\delta }_{\mathrm{iso}}=-2289\pm 2$ ppm. Additionally, these values were verified using a Herzfeld–Berger analysis of a polycrystalline sample under magic-angle spinning (MAS) conditions. Full article

Metallic biomaterials are prevalent in medical applications. In the treatment of mandibular fractures, the use of metallic biomaterials makes it possible to recover the ability to bite and partially recover speech through preventing ankylosis of the temporomandibular joints, the formation of pseudoarthritic joints, and the consolidation of reduced bones. This article presents the concept of a triaxial plate for osteosynthesis of basal fractures of the mandibular condyle, which are very common fractures in humans. Approximately half of patients with such fractures have wide (squat) condylar processes, which allows for the use of as many as three straight plates. However, installing three plates is quite troublesome, and the use of a single and transversely reinforced plate would facilitate treatment. This study proposes a plate with three reinforcements running along three divergent axes. The plate is fixed to the bone fragments with 11 screws. This concept for the treatment of basal fractures allows patients to quickly recover their primary system functions due to rigid fixation through the use of short (4 mm) screws, as there is no trauma to the medial pterygoid muscle and the mandible canal contents and no intermaxillary immobilization. Full article

To optimize the management of groundwater resources in the Bourgogne-Franche-Comté (BFC, France) region, data from the Size-Eaux database were cross-referenced with the French Reference Framework for Groundwater Bodies (GWB). The information contained in this dataset was synthesized using Principal Component Analysis (PCA), followed by Agglomerative Hierarchical Clustering (AHC) of GWBs based on their average coordinates along the main factorial axes. The results reveal 11 distinct GWB groups, each internally homogeneous in terms of chemical composition and ongoing processes responsible for intra-group variability. The distribution of the groups aligns with the region’s structural geology, lithology, and agricultural activity patterns. Livestock farming areas, prone to fecal contamination, and cereal-growing areas, characterized by high nitrate concentrations, stand out distinctly. Furthermore, the analysis of GWB groups highlights regional processes such as denitrification, confirming the existence of spatial structuring of these mechanisms beyond local specificities. The major physicochemical and bacteriological zones show strong contrasts between groups while maintaining significant internal homogeneity. Despite the region’s vast size and diversity, spanning three major watersheds, further subdivision was not necessary to obtain applicable results. These findings confirm observations made in other regions and pave the way for an optimized monitoring and surveillance strategy. Full article

Background/Objectives: Sarcopenia, defined by a loss of muscle mass, strength, and function, is a potential comorbidity in axial spondyloarthritis (axSpA). Its prevalence, along with malnutrition, remains unclear. Methods: This cross-sectional study assessed sarcopenia (using the European Working Group on Sarcopenia in Older People (EWGSOP-2) criteria), presarcopenia, and malnutrition (using the Global Leadership Initiative on Malnutrition (GLIM) criteria) in a Spanish axSpA cohort. We included 94 patients aged ≥ 50 years. Sarcopenia was evaluated using the SARC-F questionnaire and by measuring muscle strength, mass, and performance. Presarcopenia was defined as low muscle mass alone. Malnutrition was assessed using body mass index (BMI) and fat-free mass index (FFMI). Results: The prevalence of sarcopenia, presarcopenia, and malnutrition was 3.2%, 23.4%, and 10.6%, respectively. Sarcopenia correlated with worse functionality and quality of life (Bath Ankylosing Spondylitis Functional Index (BASFI) 7.6 ± 1.2 vs. 3.6 ± 2.5, p = 0.02; ASAS Health Index (ASAS-HI) 11 ± 2 vs. 5.6 ± 3.7, p = 0.03). Presarcopenia was linked to a lower BMI (24.7 ± 4.1 vs. 29.1 ± 4.2, p < 0.01), FFMI (16.1 ± 2 vs. 19.6 ± 2.6, p < 0.01), and reduced biologic treatment use (31.8% vs. 61.1%, p = 0.03). Malnourished patients had lower muscle mass (5.14 ± 0.73 vs. 6.23 ± 0.96, p < 0.01). SARC-F showed 100% sensitivity and 75.8% specificity for sarcopenia detection. Conclusions: Despite low sarcopenia prevalence, presarcopenia and malnutrition are frequent, highlighting the need for early detection in axSpA. Full article

Background: Small airway dysfunction (SAD) is associated with impaired asthma control, but small airway physiology is not routinely assessed in clinical practice. Previously, we demonstrated impulse oscillometry (IOS)-defined small airway dysfunction (SAD) in dual responders (DRs) upon bronchoprovocation with various allergens. Aim: To compare lung physiology using spirometry and IOS following bronchoprovocation with methacholine (M) and inhaled house dust mite (HDM) extract in corticosteroid-naïve asthmatic subjects. Methods: Non-smoking, clinically stable HDM-allergic asthmatic subjects (18–55 years, FEV₁ > 70% of pred.) underwent an M and inhaled HDM challenge on two separate days. Airway response was measured by IOS and spirometry, until a drop in FEV₁ ≥ 20% (PC₂₀) from post-diluent baseline (M), and up to 8 h post-allergen (HDM). Early (EAR) and late asthmatic response (LAR) to HDM were defined as ≥20% and ≥15% fall in FEV₁ from post-diluent baseline during 0–3 h and 3–8 h post-challenge, respectively. IOS parameters (Rrs5, Rrs20, Rrs5-20, Xrs5, AX, Fres) were compared between mono-responders (MRs: EAR only) and dual responders (EAR + LAR). Correlations between maximal % change from baseline after the two airway challenges were calculated for both FEV₁ and IOS parameters. Results: A total of 47 subjects were included (11 MRs; 36 DRs). FEV₁ % predicted did not differ between MR and DR at baseline, but DR had lower median PC₂₀M (0.84 (range 0.07–7.51) vs. MR (2.15 (0.53–11.29)); p = 0.036). During the LAR, DRs had higher IOS values than MRs. For IOS parameters (but not for FEV₁), the maximal % change from baseline following M and HDM challenge were correlated. PC₂₀M was inversely correlated with the % change in FEV₁ and the % change in Xrs5 during the LAR (r= −0.443; p = 0.0018 and r= −0.389; p = 0.0075, respectively). Conclusions: During HDM-induced LAR, changes in small airway physiology can be non-invasively detected with IOS and are associated with increased airway hyperresponsiveness and changes in small airway physiology during methacholine challenge. DRs have a small airways phenotype, which reflects a more advanced airway disease. Full article

Purpose: This study aimed to assess patient activation using patient activation measure 13 (PAM-13) in systemic lupus erythematosus (SLE), psoriatic arthritis (PsA), and axial spondyloarthritis (axSPA). Patients and methods: A cross-sectional study was conducted involving patients with three rheumatological conditions (SLE, PsA, and axSPA). Patients were contacted either at the clinic or through social media platforms. Data, including demographics, PAM 13, Arabic compliance questionnaire for rheumatology (ACQR), and disease-related activity scores, were collected electronically. The analyses included Chi-squared tests, linear regression, and binary logistic regression. Results: Overall, 418 patients were recruited (SLE = 323, PsA = 65, and axSPA = 30), with a mean (±SD) age of 42 ± 11 years and a female predominance (88%). PAM-13 scores did not significantly differ between the rheumatological disorders. Patients with axSPA showed significantly higher compliance than those with SLE or PsA (p = 0.012). In regression models, patients with PsA were more likely to be in activation level 1, with an OR of 2.890 (95% CI: 1.044–8.000, p = 0.0041), whereas patients with axSPA were more likely to be in activation level 4, with an OR of 2.460 (95% CI: 1.122–5.393, p = 0.025). The SLEDAI score was inversely related to the PAM-13 score (Pearson’s correlation coefficient = −0.221, p < 0.001). Conclusions: This study explored the levels of activation and medication compliance in different rheumatological conditions. Larger studies are needed to confirm these findings and explore the challenges and opportunities for improving compliance and activation. Full article

Background/Objectives. Adult medulloblastoma (AMB) patients should receive postoperative craniospinal irradiation (CSI) as a standard treatment. Volumetric intensity-modulated arc therapy (VMAT) is a promising method for CSI. This report summarizes the repositioning and dosimetric data outcomes for six AMB patients. Methods. Complete CSI and posterior cranial fossa irradiation, or tumor bed boost irradiation with Linac-based VMAT, was performed and evaluated. Patients were immobilized in the supine position with two thermoplastic masks (head-neck and abdomen). To ensure inter-fraction reproducibility during radiotherapy (RT), a single cone-beam CT (CBCT) scan for each isocenter and real-time surface-guided RT using AlignRT^® were performed daily before and during the RT session. Match values of all three translational axes (x = lateral, y = longitudinal, z = vertical) were recorded. Results. From August 2022 to September 2023, six AMB patients were treated with CSI: three women and three men with a median age of 32 (22–42). All cases were classical MB, four were low risk, and two were defined as high risk due to the metastatic disease. All patients underwent surgery; two received a gross total resection. Low-risk patients received 36 Gy for CSI and a 54 Gy boost, while high-risk patients received 39 Gy for CSI. No significant toxicities greater than G2 were observed during RT, and only two cases reported decreased platelet counts. The dose to the organs at risk was low and acceptable. The mean dose to the heart, lungs, eyes, stomach, and thyroid were 4.4 Gy, 8.5 Gy, 12 Gy, 8.7 Gy, and 11 Gy, respectively. In terms of repositioning data, 124 CBCT scans were analyzed. Inter-fraction CBCT mean values for the study population in all translational directions were inferior to 2 mm in more than 90% of cases. Conclusions. VMAT is a convenient and effective treatment for AMB. Positioning and immobilization with masks (head and neck plus abdomen) reduce inter-fraction motion. Full article

A comprehensive study was conducted at a wave energy device test site located off the northeastern coast of Taiwan to assess the influence of oceanic currents on experimental equipment. A bottom-mounted 600 kHz acoustic Doppler current profiler, equipped with integrated temperature and pressure sensors, was deployed at a depth of approximately 31 m. This study, spanning from 6 June 2023 to 11 May 2024, recorded ocean current profiles by assembling data from 50 pings every 10 min, with a resolution of one meter per depth layer. The findings reveal that variations in water levels were predominantly influenced by the M2 tidal constituent, followed by the O1, K1, and S2 tides. Notably, seawater temperature fluctuations at the seabed were modulated by tides, especially the M2 tide. A significant drop in seawater temperature was also observed as the typhoon passed through the south of Taiwan. In terms of sea surface currents, the measured maximum current speed was 71.89 cm s⁻¹, but the average current speed was only 15.47 cm s⁻¹. Tidal currents indicated that the M4 and M2 tides were the most significant, with semimajor axes and inclination angles of 8.48 cm s⁻¹ and 102.60°, and 7.00 cm s⁻¹ and 97.76°, respectively. Seasonally, barotropic tidal currents were the strongest in winter. Additionally, internal tides were identified, with the first baroclinic mode being dominant. The zero-crossing depths varied between 14 and 18 m. During the summer, the M2 baroclinic tidal current displayed characteristics of the second baroclinic mode, with zero-crossing depths at approximately 7 m and 22 m. This node aligns with results from the empirical orthogonal function analysis and correlates with the depths’ significant shifts in seawater temperature as measured by a conductivity, temperature, and depth instrument. Despite the velocities of internal tides not being strong, the directional variance between surface and bottom flows presents critical considerations for the deployment and operation of moored wave energy devices. Full article

We were tasked by Canada’s COVID-19 Immunity Task Force to describe severe adverse events (SAEs) associated with emergency department (ED) visits and/or hospitalizations in individuals with immune-mediated inflammatory diseases (IMIDs). At eight Canadian centres, data were collected from adults with rheumatoid arthritis (RA), axial spondyloarthritis (AxS), systemic lupus (SLE), psoriatic arthritis (PsA), and inflammatory bowel disease (IBD). We administered questionnaires, analyzing SAEs experienced within 31 days following SARS-CoV-2 vaccination. About two-thirds (63%) of 1556 participants were female; the mean age was 52.5 years. The BNT162b2 (Pfizer) vaccine was the most common, with mRNA-1273 (Moderna) being second. A total of 49% of participants had IBD, 27.4% had RA, 14.3% had PsA, 5.3% had SpA, and 4% had SLE. Twelve (0.77% of 1556 participants) SAEs leading to an ED visit or hospitalization were self-reported, occurring in 11 participants. SAEs included six (0.39% of 1556 participants) ED visits (including one due to Bell’s Palsy 31 days after first vaccination) and six (0.39% of 1556 participants) hospitalizations (including one due to Guillain-Barré syndrome 15 days after the first vaccination). Two SAEs included pericarditis, one involved SLE (considered a serious disease flare), and one involved RA. Thus, in the 31 days after SARS-CoV-2 vaccination in our IMID sample, very few serious adverse events occurred. As SARS-CoV2 continues to be a common cause of death, our findings may help optimize vaccination acceptance. Full article