Search Results (33)

This study experimentally evaluates the thermal performance of a compact parabolic trough solar collector (PTSC) operating under actual solar conditions in Chachapoyas, a high-Andean city in northern Peru characterized by frequent cloud cover and variable irradiance. Despite the growing interest in solar thermal systems, few studies have assessed PTC behavior under high-altitude, diffuse radiation conditions typical of Andean regions. The PTSC, aligned along the north–south axis and equipped with a manual solar tracking system, was monitored for 30 consecutive days. Solar irradiance, ambient temperature, and water inlet/outlet temperatures were recorded at 30 min intervals using a DAVIS Vantage Pro Plus weather station and infrared thermometers (±0.5 °C accuracy). Thermal efficiency was determined from the ratio of useful heat gain to incident solar energy, based on instantaneous irradiance data. Results showed peak irradiance values of 1000 W m⁻² and maximum outlet water temperatures of 85 °C, achieving an average efficiency of 68 ± 2.5%. The collector maintained stable operation even under fluctuating radiation, confirming its suitability for domestic hot-water and low-temperature industrial applications. These findings provide the first experimental evidence of efficient solar-thermal conversion in cloudy highland environments of Peru, supporting the deployment of decentralized renewable energy systems in the Andean region. Full article

Oxidative stress is believed to deteriorate production performance and cause substantial economic losses in commercial poultry farming. Resveratrol (RES) is a polyphenolic antioxidant that can improve intestinal barrier function and regulate gut microbiota composition. This study aimed to evaluate whether short-term (14 days) dietary resveratrol (1000–3000 mg/kg) mitigates dexamethasone (DEX)-induced oxidative stress and performance loss in yellow-feathered broilers. Two hundred and forty 52-day-old birds were assigned to five treatments (n = 8 pens × 6). Control (CON) and DEX groups received the basal diet; DR1, DR2 and DR3 were provided with the basal diet plus 1000, 2000 or 3000 mg/kg RES. During days 1–5, the DEX and RES (DR1, DR2 and DR3) groups were intraperitoneally injected with 5 mg/kg BW DEX; CON birds received saline. DEX significantly reduced average daily gain (ADG) and raised feed conversion ratio (FCR) (p < 0.05) without altering feed intake. RES at 1000–2000 mg/kg improved ADG, reduced FCR and lowered serum corticosterone and blood urea nitrogen while increasing albumin (p < 0.05). DEX elevated malondialdehyde (MDA) in liver and thigh muscle, suppressed liver catalase (CAT) activity, and suppressed thigh muscle superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and CAT activities. In serum, only SOD activity decreased. RES partially alleviated the abnormal changes in these antioxidant indices. Intestinally, DEX increased MDA, shortened villi and reduced the villus-to-crypt ratio, whereas RES partially reinstated ileal morphology, decreased MDA dose-dependently and linearly enhanced duodenal SOD activity (p < 0.05). DEX downregulated Occludin mRNA; RES upregulated Occludin and elevated ileal GPX2, SOD, CAT and PPAR-γ transcripts with a quadratic response to RES dose, while lowering duodenal CAT mRNA. Overall, short-term RES supplementation—particularly at 1000–2000 mg/kg—improves growth performance, meat quality and intestinal health of yellow-feathered broilers under DEX-induced oxidative stress by enhancing systemic and intestinal antioxidant capacity and reinforcing epithelial barrier integrity. Full article

The cage-free rearing of laying hens combined with probiotics promotes intestinal health. The aim of this study was to evaluate the effect of adding probiotics on the intestinal microbiota of Isa Brown laying hens raised in a cage-free system. A total of 450 Isa Brown hens, 19 weeks old, were used in a cage-free system over three 28-day cycles in a completely randomized design with five treatments and six replicates, containing 15 birds per pen. The Isa Brown hens were fed a basal ration based on corn and soybean meal; a basal ration plus a single strain of Bacillus subtilis (500 g/t); a basal ration plus a single strain, Bacillus subtilis (1000 g/t); a basal ration plus a probiotic blend (Bacillus subtilis, Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus delbrueckii, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus salivarius, Pediococcus acidilactici) at a dosage of 200 g/t; and a basal ration plus the blend at 400 g/t. From one hen per replicate, contents from the small intestine, including the duodenum, jejunum, and ileum, were collected for DNA extraction and bacterial species identification. There was an increase in Helicobacter brantae, which was quantified at 86% in the diet containing 1000 g/t of the probiotic single strain of Bacillus subtilis and 87% in the diet containing 500 g/t dosage, in comparison to the basal ration. With the probiotic blend at 200 g/t, 37% Lactobacillus crispatus and 21% Lactobacillus aviarius were observed, while the dosage of 400 g/t of the probiotic blend increased the level of Lactobacillus kitasatonis to 68% compared to the basal ration. The inclusion of 200 g/t of the probiotic blend proved to be more beneficial to the small intestinal microbiota of laying hens. Full article

Coccidiosis, caused by Eimeria spp., is a major economic burden in poultry production, prompting growing interest in natural alternatives to synthetic anticoccidials. This study evaluated the use of Polygain™, a sugarcane-derived polyphenol-rich feed material, as a natural anticoccidial in broiler chickens experimentally challenged with Eimeria tenella, E. maxima, and E. acervulina. A total of 144 Ross 308 chicks were allocated to six groups: uninfected–untreated control, infected–untreated control, infected plus nicarbazin + narasin, and three Polygain™ treatment groups (250, 500, and 1000 ppm). Birds were orally challenged with mixed oocysts on day 14. Parameters assessed included body weight gain (BWG), lesion scores (LS), oocyst per gram (OPG), and calculated indices such as relative oocyst production (ROP), reduction in lesion score (RLS), percent optimum anticoccidial activity (POAA), and anticoccidial index (ACI). Polygain™ reduced intestinal lesions (p < 0.05), particularly in the caecum, with complete lesion resolution observed at 1000 ppm by 21 days post-infection. Polygain™ ACI values (143–146) were limited in comparison to nicarbazin + narasin treatment (ACI 160). These findings demonstrate that Polygain™ supplementation confers measurable protective dose related effects against coccidiosis without impairing growth performance, supporting its potential as a natural feed material for integrated coccidiosis management. Full article

Background: The epidermal growth factor receptor (EGFR) is overactive in many tumors. This phase I trial evaluated the safety and preliminary efficacy of afatinib plus capecitabine in refractory pancreatic ductal adenocarcinoma (PDA), biliary tract cancers (BTC), and other solid tumors. Patients and Methods: The phase Ia study had a 3 + 3 design with capecitabine 1000 mg/m² twice daily on days 1–14 and afatinib 20 mg, 30 mg, or 40 mg daily in 21-day cycles. In phase Ib, 15 patients, each with PDA and BTC, were treated at maximum tolerated dose (MTD). Results: A total of 41 patients were enrolled. No dose-limiting toxicities were observed, and the MTD was 40 mg afatinib plus capecitabine. Among 36 response-evaluable patients, one had a partial response (3%), and eight (22%) had stable disease. Median progression-free survival (PFS) was 1.9 months (95% CI 1.0, 2.0) for PDA and 1.9 months (95% CI 1.6, 3.4) for BTC. Median overall survival (OS) was 3.2 months (95% CI 2.0, 5.8) for PDA, and 4.6 months (95% CI 1.9, 6.1) for BTC. Median OS was 5.8 months (95% CI 2.0, 9.6) for KRAS^WT PDA, and 5.0 months (95% CI 1.6, 6.1) for KRAS^WT BTC, vs. 3.9 months (95% CI 1.9, 5.8) for KRAS^MUT PDA and 3.1 months (95% CI 1.0, 22.8) for KRAS^MUT BTC, respectively. Conclusions: Afatinib plus capecitabine is tolerable but does not have clinically meaningful efficacy in refractory PDA/BTC. Future studies should test novel anti-EGFR/HER2 therapies in KRAS^WT cancers further selected with a comprehensive molecular profile. Full article

Background/Objectives: Empirical antimicrobial therapy for neonatal early-onset sepsis (EOS) comprises ampicillin and gentamicin. However, multidrug-resistant organisms are increasing worldwide, thus inflicting a global burden. We identified the incidence and risk factors of neonates with pathogenic isolates that were not susceptible to treatment comprising a combination of ampicillin and gentamicin (non-susceptible group). Methods: This retrospective study included neonates diagnosed with EOS between 2004 and 2023. All patients with EOS and positive culture results within 72 h of birth were reviewed. Patients in the non-susceptible and susceptible groups were analyzed using a multivariable logistic regression model. Results: Sixty pathogenic isolates and 55 neonates with EOS were observed over the course of 20 years. The incidence and case fatality rates of EOS were 0.88 per 1000 live births and 41.8%, respectively. Acinetobacter baumannii was the most common EOS pathogenic isolate (19/60 pathogenic isolates; 12/19 resistant to carbapenems). Pathogenic isolates were susceptible to ampicillin or gentamicin (59%), ampicillin or cefotaxime (42%), and ampicillin or amikacin (72%). Data regarding susceptibility to ampicillin and gentamicin of 49 neonates were available. A multivariable analysis revealed that patients in the non-susceptible group (n = 18) were more likely to experience late-onset EOS (48–72 h; p = 0.01) and require endotracheal intubation on day 1 (p = 0.04) compared to patients in the susceptible group (n = 31). Conclusions: In areas with high multidrug resistance, broader-spectrum antibiotic therapy (ampicillin plus amikacin) should be considered for neonates who develop clinical sepsis within 48–72 h of birth and experience respiratory failure at birth. Full article

Wildlife behavior can be influenced by the deployment of sensory cues in a landscape, but different cues vary in the strength and duration of their effectiveness. We aimed to identify the most effective and cost-efficient countermeasures (sensory cues) to deter wild boar (Sus scrofa) entry and damage to cornfields in Hunchun, Jilin Province, China. These cornfields have experienced severe damage by wild boars during the critical 30-day period when this crop was ripening. From 2016 to 2021, different countermeasures were applied sequentially seeking to control this damage by using either (1) visual deterrents, i.e., solar blinkers of different colors; (2) auditory deterrents, i.e., playbacks of Amur tiger (Panthera tigris altaica) calls, wild boar calls, or wolf (Canis lupus) calls; (3) tactile deterrents, i.e., electric fencing; (4) olfactory deterrents, i.e., Adult Amur tiger feces; or (5) various combined deterrents. We first evaluated the effectiveness of these broad categories, then performed a detailed analysis of the individual countermeasures to assess their specific deterrence effectiveness and duration. A cost-effective analysis was subsequently performed on the most effective countermeasures to evaluate the best option for practical applications. Across the broad categories of deterrents, the tactile group proved the most effective overall. For individual deterrents, the seven countermeasures showing significantly higher effectiveness than the others tested included the following: (1) 1000 mA red solar blinker (32.25 ± 4.22 days), (2) 1000 mA yellow solar blinker (29.67 ± 4.58 days), (3) 1000 mA green solar blinker (29.58 ± 5.60 days), (4) electric fencing with three wires (29.67 ± 0.58 days), (5) electric fencing with two wires (28.00 ± 2.00 days), (6) Adult Amur tiger calls for 15 s and wild boar calls for 15 s plus a combined 30 s plus a blank recording for 5 min (26.50 ± 2.38 days), and (7) Adult Amur tiger feces and calls (27.34 ± 2.94 days). Except for the Adult Amur tiger feces and calls, each countermeasure would cover most of the period over which control is necessary (30 days). The 1000 mA red solar blinker of achieved the highest repellency per cost ratio (0.31) at 30.29 IUS$/hm² but showed reduced effectiveness over time. Although electric fencing with three wires offers longer deterrence, its cost-effectiveness ratio was lower (0.27) due to higher installation and maintenance costs at 319.69 IUS$/hm². The 1000 mA red solar blinker offers a highly cost-effective short-term deterrent, while the electric fencing with three wires provides durable, long-term protection despite its higher costs. Balancing cost and duration can optimize wild boar deterrence strategies across different management needs. Full article

Color stability of acrylic resins is essential for preserving the aesthetic appearance of denture bases over time. This study explores how food pigments and thermal changes affect the color stability of commonly used denture base resins. Four acrylic resins were tested: three heat-cured acrylic resins with different characteristics (Zhermack^® Villacryl H Plus V2, H Plus V4, and H Rapid FN V4) and one self-cured acrylic resin (Zhermack^® Villacryl S V4). To simulate the oral environment, the resins underwent 1000 thermal cycles between 5 °C and 55 °C, followed by a 7-day immersion period in beverages such as coffee, red wine, a caramel-colored soft drink (cola), and distilled water (control), forming sixteen group of specimens (n = 5). Color changes (∆E) were measured using the VITA Easyshade V^® spectrophotometer, following the CIEDE2000 standard. The findings revealed that thermal aging caused noticeable color changes in all resins (p < 0.001). Red wine led to the most intense discoloration, followed by coffee. The caramel-colored soft drink caused moderate staining, while distilled water had a negligible effect. The type of polymerization did not affect the degree of discoloration, as no significant differences were found between the resins after exposure to beverages (p > 0.05). Overall, this study highlights how both internal and external factors impact the appearance of acrylic resins. Thermal aging can accelerate polymer degradation, while pigments in beverages cause visible staining. Among the tested beverages, red wine proved to be the most aggressive due to its high pigment concentration and low pH. These findings emphasize the need for improved material formulations to enhance the longevity and aesthetic performance of dentures. Full article

Tanacetum vulgare L. has been traditionally applied as a remedy for headaches, rheumatism, digestion, respiratory and neurological problems, and other medical conditions. However, the literature data on its effects on cognitive function are scarce. The aim of the present work was to evaluate the effects of two doses of T. vulgare alcohol extract on cognitive functions, hippocampal brain-derived neurotrophic factor (BDNF) expression, and organ toxicity in rats. Rats were treated with T. vulgare 200 mg/kg (TV 200) and 1000 mg/kg (TV 1000) for 28 days. After one week of pre-treatment, the animals were subjected to a series of tests. We found that in the active avoidance test, only TV 200 improved learning and memory, while in the passive avoidance test, both doses facilitated these processes. In addition, the two doses enhanced spatial memory. In the elevated plus maze test, only the higher dose of TV 1000 resulted in anxiolytic-like behavior. Both doses of the extract significantly increased the hippocampal expression of BDNF. We suggest that increased neurotrophic factor expression could be one of the important mechanisms underlying the cognition-enhancing effects of T. vulgare extract. Full article

The co-product canola meal contains little fat and has been used in swine production as a protein source for several decades. More recently, locally produced canola cake has also become available that contains important quantities of residual oil. Both canola co-products contain a considerable quantity of phosphorus (P) with low availability. Phytase supplementation can increase P digestibility in canola meal but its efficacy remains unclear for canola cake containing high residual oil. To explore whether phytase supplementation can increase digestibility of P and other nutrients in canola cake, four diets containing 500 g of locally produced cold-pressed canola cake or canola meal, with or without supplemental phytase (Ronozyme HiPhos; Aspergillus oryzae origin)/kg, were fed to seven pigs (initial body weight; 55.9 ± 3.8 kg) in four 9-day periods following a 4 × 4 Latin square plus a 4 × 3 Youden square. Phytase supplementation increased phytase activity from below the detection limit to reach a minimum of 1000 phytase units/kg in the canola meal and cake diets; respectively. Phytase supplementation increased (p < 0.05) coefficients of ileal and total tract digestibility of P by 60% and 46% for canola meal and 76% and 57% for canola cake, respectively, but did not affect the digestibility of crude protein or gross energy. Ileal or total tract digestibility of P did not differ between the canola cake and canola meal diets in growing-finishing pigs. In conclusion, fungal phytase is effective in increasing the P digestibility of canola cake similar to in canola meal fed to growing-finishing pigs. The similar ileal or total tract digestibility of P in canola meal and cake diets either with or without phytase supplementation indicated that the residual oil in canola cake did not affect P digestion and did not affect the efficacy of phytase in increasing P digestibility. Full article

The time of a satellite navigation system is primarily generated by the main control station of the ground system. Consequently, when ground stations fail, there is a risk to the continuous provision of time services to the equipment and users. Furthermore, the anticipated launch of additional satellites will further strain the satellite–ground link. Next-generation satellite navigation systems will rely on time deviation measurements from inter-satellite links to independently establish and maintain a space-based time reference, enhancing the system’s reliability and robustness. The increasing number of low-Earth-orbit satellite navigation constellations provides ample resources for establishing a space-based time reference. However, this also introduces challenges, including extensive time scale computations, increased link noise, and low clock resource utilization. To address these issues, this paper proposes a Distributed Kalman Plus Weight (D-KPW) algorithm, which combines the benefits of Kalman filtering and the weighted average algorithm, balancing the performance with computational resources. Furthermore, an adaptive clock control algorithm, D-KPW (Control), is developed to account for both the short-term and long-term frequency stability of the time reference. The experimental results demonstrate that the frequency stability of the time reference established by the D-KPW (Control) algorithm reaches $7.40\times {10}^{-15}$ and $2.30\times {10}^{-15}$ for sampling intervals of 1000 s and 1,000,000 s, respectively, outperforming traditional algorithms such as ALGOS. The 20-day prediction error of the time reference is 1.55 ns. Compared to traditional algorithms such as AT1, ALGOS, Kalman, and D-KPW, the accuracy improves by 65%, 65%, 66%, and 67%, respectively. Full article

The development and course of inflammatory bowel disease (IBD) are significantly influenced by inflammation and oxidative stress. Antioxidant therapy is a promising therapeutic option to enhance the clinical results of these individuals in this particular scenario. The purpose of this study is to assess the impact of curcumin, with or without piperine, on cytokines, fecal calprotectin (CalF), and oxidative stress enzymatic and non-enzymatic indicators in patients with IBD. Methods: Patients with Crohn’s disease (CD) or ulcerative colitis (UC) who were at least 18 years old and had intact liver and kidney function participated in this randomized, double-blind trial (trial registration: ensaiosclinicos.gov.br as RBR-89q4ydz). For 12 weeks, participants were randomly assigned to one of three groups: placebo, curcumin (1000 mg/day), or curcumin plus piperine (1000 mg + 10 mg/day). In order to examine oxidative stress indicators, CalF, and pro-inflammatory cytokines, blood and fecal samples were obtained, both prior to and following the intervention time. Results: After adjusting for age, sex, and type of IBD, the curcumin plus piperine group had substantially higher serum levels of superoxide dismutase (SOD) than the placebo group (4346.9 ± 879.0 vs. 3614.5 ± 731.5; p = 0.041). There were no discernible variations between the groups in CalF, inflammatory markers, or other indicators of oxidative stress. Conclusions: In patients with inflammatory bowel disease (IBD), our study indicates that a 12-week curcumin plus piperine treatment effectively increases enzymatic antioxidant defense, especially SOD. These results demonstrate the potential therapeutic benefits of managing redox imbalance in individuals with IBD. Full article

Background: Police first responder systems also including automated external defibrillation (AED) has in the past shown considerable impact on favourable outcomes after out-of-hospital cardiac arrest (OHCA). While short hands-off times in chest compressions are known to be beneficial, various AED models use different algorithms, inducing longer or shorter durations of crucial timeframes along basic life support (BLS). Yet, data on details of these differences, and also of their potential impact on clinical outcomes are scarce. Methods: For this retrospective observational study, patients with OHCA of presumed cardiac origin and initially shockable rhythm treated by police first responders in Vienna, Austria, between 01/2013 and 12/2021 were included. Data from the Viennese Cardiac Arrest Registry and AED files were extracted, and exact timeframes were analyzed. Results: There were no significant differences in the 350 eligible cases in demographics, return of spontaneous circulation, 30-day survival, or favourable neurological outcome between the used AED types. However, the Philips HS1 and -FrX AEDs showed immediate rhythm analysis after electrode placement (0 [0–1] s) and almost no shock loading time (0 [0–1] s), as opposed to the LP CR Plus (3 [0–4] and 6 [6–6] s, respectively) and LP 1000 (3 [2–10] and 6 [5–7] s, respectively). On the other hand, the HS1 and -FrX had longer analysis times of 12 [12–16] and 12 [11–18] s than the LP CR Plus (5 [5–6] s) and LP 1000 (6 [5–8] s). The duration from when the AED was turned on until the first defibrillation were 45 [28–61] s (Philips FrX), 59 [28–81] s (LP 1000), 59 [50–97] s (HS1), and 69 [55–85] s (LP CR Plus). Conclusion: In a retrospective analysis of OHCA-cases treated by police first responders, we could not find significant differences in clinical patient outcomes concerning the respective used AED model. However, various differences in time durations (e.g., electrode placement to rhythm analysis, analysis duration, or AED turned on until first defibrillation) along the BLS algorithm were seen. This opens up the question of AED-adaptations and tailored training methods for professional first responders. Full article

High fertilization rates and pesticides are required for the intensive production of strawberries, which offer several therapeutic health benefits. Recently, chitosan (CHI), and phosphorus fertilizer based on Micro Carbon Technology^TM (MCT-P) were applied to encourage strawberry sustainable production and enhance phosphorus-use efficiency. Field trials were conducted throughout 2020/2021 and 2021/2022, to evaluate the effectiveness of MCT–P and CHI in improving strawberry cv. Fortuna growth and yield as well as their quality. Foliar spraying of CHI and MCT-P considerably improved strawberry plant growth (i.e., plant height, secondary crown number per plant, leaf number and area per plant, and foliage fresh weight), photosynthetic pigment concentration (chlorophyll_a, chlorophyll_b, and carotenoids), as well as its yield and quality (early fruit yield, total yield, average fruit weight, fruit firmness, fruit dry matter %, soluble solid content, total sugars (%), ascorbic acid, acidity, and anthocyanin). Compared to untreated plants, 1200 mgL⁻¹ MCT-P and 1000 mg/L CHI supplementation was the most effective concentration for improving all studied characteristics. The interaction between CHI and MCT-P had a greater impact on all examined characteristics. It is recommended to spray strawberry cv. Fortuna with 1200 mg/L MCT-P plus 1000 mg/L CHI every two weeks, from 60 days after transplanting until two weeks before the end of harvesting season for the best fruit yield and quality. Full article

In hemodynamically stable patients, both anemia and red blood cell (RBC) transfusion may be detrimental to patients; hence, a decision regarding RBC transfusion should be based on thorough risk–benefit assessment. According to hematology and transfusion medicine organizations, RBC transfusion is indicated when recommended hemoglobin (Hb) triggers are met, and symptoms of anemia are present. The aim of our study was to examine the appropriateness of RBC transfusions in non-bleeding patients at our institution. We performed a retrospective analysis of all RBC transfusions performed between January 2022 and July 2022. The appropriateness of RBC transfusion was based on the most recent Association for the Advancement of Blood and Biotherapies (AABB) guidelines and some additional criteria. The overall incidence of RBC transfusions at our institution was 10.2 per 1000 patient-days. There were 216 (26.1%) RBC units appropriately transfused and 612 (73.9%) RBC units that were transfused with no clear indications. The incidence of appropriate and inappropriate RBC transfusions were 2.6 and 7.5 per 1000 patient-days, respectively. The most frequent clinical situations when RBC transfusion was classified as appropriate were: Hb < 70 g/L plus cognitive problems/headache/dizziness (10.1%), Hb < 60 g/L (5.4%), and Hb < 70 g/L plus dyspnea despite oxygen therapy (4.3%). The most frequent causes of inappropriate RBC transfusions were: no Hb determination pre-RBC transfusion (n = 317) and, among these, RBC transfused as a second unit in a single-transfusion episode (n = 260); absence of anemia sings/symptoms pre-transfusion (n = 179); and Hb concentration ≥80 g/L (n = 80). Although the incidence of RBC transfusions in non-bleeding inpatients in our study was generally low, the majority of RBC transfusions were performed outside recommended indications. Red blood cell transfusions were evaluated as inappropriate mainly due to multiple-unit transfusion episodes, absence of anemia signs and/or symptoms pre- transfusion, and liberal transfusion triggers. There is still the need to educate physicians on appropriate indications for RBC transfusion in non-bleeding patients. Full article