Search Results (20)

This study investigates the dynamic operation of a pilot-scale precipitation reactor designed to produce oxygenated phosphocalcium apatites with controlled composition and low crystallinity, closely mimicking the mineral phase of bone. Our approach is based on integrating kinetic monitoring and dynamic reactor control to direct the formation of apatites with tailored structural and chemical properties. Three synthesis routes were explored using CaCO₃, Ca(NO₃)₂, and CaCl₂ as calcium precursors, under optimized Ca/P molar ratios. The evolution of ionic concentrations (Ca²⁺, PO₄³⁻), peroxide and molecular oxygen incorporation, and carbonate content was monitored over a reaction time range of 2 min to 4 h. Characterization by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and chemical analysis revealed a time-dependent transformation of amorphous phases into poorly crystalline apatites with specific textures. After 60 min, the Ca/P atomic ratio stabilized at approximately 1.575, and the resulting apatites exhibited structural features comparable to those of human bone. This study highlights the influence of reactor operation time on precipitation kinetics and the properties of bioactive apatites in a scalable system. The results offer promising prospects for the large-scale production of bone-mimetic materials. However, the lack of biological validation remains a limitation. Future studies will assess the cytocompatibility and bioactivity of these materials to confirm their potential for biomedical applications. Full article

The hydrogel patent landscape is characterized by rapid growth and diverse applications, particularly in the biomedical field. Advances in material science, chemistry, novel manufacturing techniques, and a deeper understanding of biological systems have revolutionized the development of hydrogel-based biomaterials. These innovations have led to enhanced properties and expanded applications, particularly in regenerative medicine, drug delivery, and tissue engineering, positioning hydrogels as a pivotal material in the future of biomedical engineering. In this study, an updated patent landscape for hydrogel-based biomaterials is proposed. By analyzing patent documents, classifications, jurisdictions, and applicants, an overview is provided to characterize key trends and insights. The analysis reveals that hydrogel-related patents are experiencing significant growth, with a strong focus on biomedical applications. Foundational research in hydrogel formation remains dominant, with 96,987 patent documents highlighting advancements in crosslinking techniques, polysaccharide-based materials, and biologically active hydrogels for wound care and tissue regeneration. The United States and China lead in hydrogel-related patent filings, with notable contributions from Europe and a high number of international patents under the Patent Cooperation Treaty (PCT) system, reflecting the global interest in hydrogel technologies. Moreover, emerging innovations include biodegradable hydrogels designed for tissue regeneration, wearable hydrogel-based sensors, and advanced therapeutic applications such as chemoembolization agents and vascular defect treatments. The increasing integration of bioactive elements in hydrogel systems is driving the development of multifunctional biomaterials tailored to specific medical and environmental needs. While this study focuses on patent trends, the alignment between hydrogel research and patenting activities underscores the role of patents in bridging scientific discoveries with industrial applications. Future research could explore patent citation analysis and impact assessments to gain deeper insights into the technological significance of hydrogel-related inventions. Finally, a selection of the top 10 recent active and granted patents in the field of hydrogel-based biomaterials is presented as an illustrative example of innovation in this area and to illustrate cutting-edge innovations. Full article

LGP cylinders are necessary for fuel storage and home heating. To avoid material and human risk, it is essential to maintain their structural integrity. Extensive mechanical research studies and physical tests are necessary for its design. This paper investigates the mechanical performance of the storage capacity of an LPG cylinder under static loading. The authors integrate and adapt IGA with the T-Splines function for geometry modeling and numerical analysis in the context of linear elasticity. The main focus is on the strains and stress numerical results. The obtained results are examined and verified with the FEM in Abaqus/Standard. The results found show that the storage capacity of a single cylinder is equivalent to 15 empty cylinders. This study also demonstrates that the T-Splines method is a promising alternative for numerically analyzing the mechanical structure performance of LPG cylinders, particularly in energy storage issues. Full article

This paper explores and discusses how wing structures vibrate by using the Mindlin–Reissner plate theory, which takes into consideration the effects of transverse shear deformation and rotary inertia. This theory works well for thicker structures, like aircraft wings, where it gives accuracy by detecting shear and rotation effects. FGMs, or functionally graded materials, are used in aviation to enhance structural patterns and reduce stress points by gradually changing material properties along the wing thickness based on the volume fraction index. Finite element method (FEM) simulations were conducted to compare the natural frequencies and mode shapes of tapered and interpolated wing geometries. The results indicate that interpolated meshes exhibit higher natural frequencies due to increased stiffness, whereas tapered meshes show lower frequencies due to their flexibility. Validation through ANSYS simulations confirms the accuracy of the FEM results, highlighting the influence of geometry and material gradation on vibrational behavior. The findings offer valuable insights for aerospace applications, supporting the development of lightweight and efficient wing designs. Full article

In the context of the automotive industry, this paper proposes an enhancement of the numerical simulation using FEM and performing material choosing with the Ashby method for automotive brake discs, using the symmetric shape of the disc. Automotive braking involves the dissipation of kinetic energy through heat generation due to friction, a physical phenomenon that alters the mechanical properties of brake discs. This prompts automotive development engineers to investigate new materials capable of absorbing heat while maintaining their mechanical properties. A thermomechanical study of a ventilated front brake disc has successfully demonstrated a good performance of cast iron because the equivalent stress is significantly lower than the elastic limit, with a margin of approximately 73 MPa. Compared to validated results extracted from the state of the art, the adopted methodology gives more realistic results with minimum CPU requirements, where the total time of calculation is around 40 min. More than that, the results are suitable to be used for studying durability and other properties like mechanical impact and fatigue. Full article

Polysaccharide-based carriers as biomaterials for drug delivery have been inspiring scientists for years due to their exceptional characteristics, such as nontoxicity, biocompatibility, and degradability, as they are able to protect pharmaceutically active molecules and provide their controlled/modified release. This review focuses on selected drug delivery systems based on natural polymers, namely fucoidan, pullulan, dextran, and pectin, with the aim of highlighting published patent documents. The information contained in patents is very important because it is usually not published in any other document and is much less discussed as the state of the art in the scientific literature. The Espacenet—European Patent Office database and the International Patent Classification were used for the research to highlight the specific search procedure. The presented analysis of the innovative state of the art includes an overview from the first patent applications to the latest granted patents in this field. Full article

Hyaluronic acid-based hydrogels are emerging as highly versatile materials for cost-effective biosensors, capable of sensitive chemical and biological detection. These hydrogels, functionalized with specific groups, exhibit sensitivity modulated by factors such as temperature, pH, and analyte concentration, allowing for a broad spectrum of applications. This study presents a patent-centered overview of recent advancements in hyaluronic acid hydrogel biosensors from 2003 to 2023. A total of 50 patent documents—including 41 patent applications and 9 granted patents—reveal a growing interest, primarily driven by United States-based institutions, which account for approximately 54% of all filings. This trend reflects the strong collaboration between universities, industry, and foundations in pushing this technology forward. Most patented technologies focus on biosensors for in vivo blood analysis, measuring critical parameters such as gas concentration and pH, with particular emphasis on glucose monitoring via tissue impedance using enzyme-immobilized oxidase electrodes. Additionally, the 9 granted patents collectively showcase key innovations, highlighting applications from continuous glucose monitors to implantable vascular devices and sweat analyte detection systems. These patents underscore the adaptability and biocompatibility of hyaluronic acid hydrogels, reinforcing their role in enhancing biosensor performance for real-time health monitoring. In summary, this overview highlights the importance of patent analysis in tracking and directing research and development, helping to clarify the field’s evolution and identify innovation gaps for hyaluronic acid-based hydrogel biosensors. Full article

This paper discusses novel numerical techniques for studying the damage to automotive safety components in carbon fiber reinforced polymer (CFRP) deployed in the automotive industry to protect passengers, high voltage batteries and powertrains from rear impacts. The idea proposed in the manuscript is to use Newmark’s methodology with the FEM for the numerical description of the explicit dynamic model of the components facing the standard impactor, following the Euro NCAP protocol. Using an explicit dynamic Radioss rear crash box, we have successfully demonstrated normal behavior for CFRP materials, where the value of kinetic energy is close to the theoretical value. Moreover, the simulation provides a behavior consistent with previous successful studies because the maximum dynamic time is the same as the total damage (0.10 ms). Full article

In this paper, we propose a new approach for numerically simulating the growth of cracks in unidirectional composite materials, termed extended isogeometric analysis, evaluating the maximum stress intensity factor and T-stress. To validate our approach, we used a small anisotropic plate with two edge cracks, beginning with formulating the governing equations based on the energy integral method, Stroh’s Formula, and the Elastic Law describing the behaviour of anisotropic materials, while considering boundary conditions and initial states. A MATLAB code was developed to solve these equations numerically and to post-process the tensile stress and the stress intensity factor (SIF) in the first mode. The results for the SIF closely match those obtained using the extended finite element method (X-FEM), with a discrepancy of only 0.0021 Pa·m^0.5. This finding underscores the credibility of our approach. The extended finite element method has demonstrated robustness in predicting crack propagation in composite materials in recent years, leading to its adoption by several widely used software packages in various industries. Full article

Six cattle heads which tested positive against bovine tuberculosis (bTB) in Morocco were investigated to confirm the disease and to determine the source(s) of infection. Polymerase Chain Reaction (PCR) was directly performed on tissue samples collected from slaughtered animals. All investigated animals tested positive to PCR for the Mycobacterium bovis sub-type. Bacteriological isolation was conducted according to the technique recommended by WOAH for the cultivation of the Mycobacterium tuberculosis Complex (MBTC). Whole genome sequencing (WGS) was carried out on six mycobacterial isolates and the phylogenic tree was constructed. The six Moroccan isolates fit with clades II, III, IV, V and VII and were confirmed to belong to the clonal complexes Eu2, Unknown 2 and 7 as well as to sublineages La1.7.1, La1.2 and La1.8.2. The significant Single Nucleotide Polymorphism (SNPs) ranged from 84 to 117 between the isolates and the reference M. bovis strain and from 17 to 212 between the six isolates. Considering the high resolution of WGS, these results suggests that the source of infection of the bTB could be linked to imported animals as five of the investigated reactor animals were imported a few months prior. WGS can be a useful component to the Moroccan strategy to control bTB. Full article

In this paper, a novel adaptive sliding mode controller (SMC) was designed based on a robust law considering disturbances and uncertainties for autonomous ground vehicle (AGV) longitudinal dynamics. The robust law was utilized in an innovative method involving the upper bounds of disturbances and uncertainties. Estimating this lumped uncertainty upper limit based on a neural network approach allowed its online knowledge. It guided the controller to withstand the disturbance and to compensate for the uncertainties. A stability analysis, according to Lyapunov, was completed to confirm the asymptotic convergence of the states to the desired state. The effectiveness and benefits of the planned approach were scrutinized by simulations and comparative studies. Full article

Accurate and timely traffic information is a vital element in intelligent transportation systems and urban management, which is vitally important for road users and government agencies. However, existing traffic prediction approaches are primarily based on standard machine learning which requires sharing direct raw information to the global server for model training. Further, user information may contain sensitive personal information, and sharing of direct raw data may lead to leakage of user private data and risks of exposure. In the face of the above challenges, in this work, we introduce a new hybrid framework that leverages Federated Learning with Local Differential Privacy to share model updates rather than directly sharing raw data among users. Our FL-LDP approach is designed to coordinate users to train the model collaboratively without compromising data privacy. We evaluate our scheme using a real-world public dataset and we implement different deep neural networks. We perform a comprehensive evaluation of our approach with state-of-the-art models. The prediction results of the experiment confirm that the proposed scheme is capable of building performance accurate traffic predictions, improving privacy preservation, and preventing data recovery attacks. Full article

Water contamination is one of the most urgent concerns confronting the world today. Heavy metal poisoning of aquatic systems has piqued the interest of various researchers due to the high toxicity and carcinogenic consequences it has on living organisms. Due to their exceptional attributes such as strong reactivity, huge surface area, and outstanding mechanical properties, nanomaterials are being produced and employed in water treatment. In this review, recent advances in the use of nanomaterials in nanoadsorptive membrane systems for wastewater treatment and heavy metal removal are extensively discussed. These materials include carbon-based nanostructures, metal nanoparticles, metal oxide nanoparticles, nanocomposites, and layered double hydroxide-based compounds. Furthermore, the relevant properties of the nanostructures and the implications on their performance for water treatment and contamination removal are highlighted. The hydrophilicity, pore size, skin thickness, porosity, and surface roughness of these nanostructures can help the water permeability of the nanoadsorptive membrane. Other properties such as surface charge modification and mechanical strength can improve the metal adsorption effectiveness of nanoadsorptive membranes during wastewater treatment. Various nanocomposite membrane fabrication techniques are also reviewed. This study is important because it gives important information on the roles of nanomaterials and nanostructures in heavy metal removal and wastewater treatment. Full article

Temperature-induced, rapid changes in the viscosity and reproducible 3-D structure formation makes thermos-sensitive hydrogels an ideal delivery system to act as a cell scaffold or a drug reservoir. Moreover, the hydrogels’ minimum invasiveness, high biocompatibility, and facile elimination from the body have gathered a lot of attention from researchers. This review article attempts to present a complete picture of the exhaustive arena, including the synthesis, mechanism, and biomedical applications of thermosensitive hydrogels. A special section on intellectual property and marketed products tries to shed some light on the commercial potential of thermosensitive hydrogels. Full article

Highly active anti-retroviral therapy (HAART) is prescribed for HIV infection and, to a certain extent, limits the infection’s spread. However, it cannot completely eradicate the latent virus in remote and cellular reservoir areas, and due to the complex nature of the infection, the total eradication of HIV is difficult to achieve. Furthermore, monotherapy and multiple therapies are not of much help. Hence, there is a dire need for novel drug delivery strategies that may improve efficacy, decrease side effects, reduce dosing frequency, and improve patient adherence to therapy. Such a novel strategy could help to target the reservoir sites and eradicate HIV from different biological sanctuaries. In the current review, we have described HIV pathogenesis, the mechanism of HIV replication, and different biological reservoir sites to better understand the underlying mechanisms of HIV spread. Further, the review deliberates on the challenges faced by the current conventional drug delivery systems and introduces some novel drug delivery strategies that have been explored to overcome conventional drug delivery limitations. In addition, the review also summarizes several nanotechnology-based approaches that are being explored to resolve the challenges of HIV treatment by the virtue of delivering a variety of anti-HIV agents, either as combination therapies or by actively targeting HIV reservoir sites. Full article