Biomedicines Webinar | Morpho-Molecular and Genetic Basis of Cardiomyopathies, 11 December 2025

Cardiomyopathies include several heart muscle diseases that are often incompletely defined in terms of cause and pathway and often poorly responsive to the proposed treatment. Even in largely recognized entities such as myocarditis, the adoption of the effective therapy is still debated and the agents involved are being increasingly identified by the new-generation sequencing technique. In fact, the morphomolecular investigation of endomyocardial biopsy samples appears to be inevitable to obtain a personalized and most effective treatment.

Regarding the origin of cardiac electrical instability, the direct involvement of conduction tissue (CT) is recognizable in endomyocardial biopsy examination and the possibility to explore CT damage through the determination of CT main molecular complex HCN4 in the peripheral blood appears as a likely prospective option. Many rare diseases phenotyipically present as cardiomyopathies and their definition and identification are crucial for appropriate management.

Nevertheless, even the administration of the lacking molecular component (i.e., enzyme replacement therapy—ERT) can be clinically unsatisfactory. Recently, it has been shown that ERT delivery can be limited in Fabry disease cardiomyopathy by a reduced expression of mannose-6-phosphate receptor that provides its uptake at the level of cell membrane as well as its targeting into lysosomes.

The aim of the present webinar is to update the latest morpho-molecular and genetic knowledge in cardiomyopathy.

Date: 11 December 2025
Time: 2:00 p.m. CET | 8:00 a.m. EST | 9:00 p.m. CST Asia
Webinar ID: 875 7695 1210
Website: https://sciforum.net/event/Biomedicines-19

Speaker/Presentation	Time in CET	Time in EST	Time in CST Asia
Prof. Dr. Andrea Frustaci Chair Introduction	2:00–2:10 p.m.	8:00–8:10 a.m.	9:00–9:10 p.m.
Prof. Dr. Andrea Frustaci Morpho-Molecular Substrate of Resistance to Enzyme Replacement Therapy in Fabry Disease Cardiomyopathy	2:10–2:30 p.m.	8:10–8:30 a.m.	9:10–9:30 p.m.
Prof. Dr. Heinz-Peter Schultheis Diagnosis and Treatment of Viral Inflammatory Cardiomyopathy	2:30–2:50 p.m.	8:30–8:50 a.m.	9:30–9:50 p.m.
Prof. Dr. Matteo Antonio Russo Electron-Microscopy in Human Cardiomyopathies	2:50–3:10 p.m.	8:50–9:10 a.m.	9:50–10:10 p.m.
Prof. Dr Alessandro De Luca Novel Genetic Contributes to Characterization of Cardiomyopathies	3:10–3:30 p.m.	9:10–9:30 a.m.	10:10–10:30 p.m.
Q&A Session	3:30–3:45 p.m.	9:30–9:45 a.m.	10:30–10:45 p.m.
Prof. Dr. Andrea Frustaci Closing of Webinar	3:45–3:50 p.m.	9:45–9:50 a.m.	10:45–10:50 p.m.

After registering, you will receive a confirmation email outlining how to join this webinar. Registrations with academic institutional email addresses will be prioritized.

Unable to attend? Register anyway, and we will let you know when the recording is available to watch.

Webinar Chair and Keynote Speakers:

Prof. Dr. Andrea Frustaci, Cellular and Molecular Cardiology Lab, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy;
Prof. Dr. Heinz-Peter Schultheiss, Institut Kardiale Diagnostik und Therapie (IKDT), Berlin, Germany;
Prof. Dr. Matteo Antonio Russo, IRCCS San Raffaele Rome, Italy;
Prof. Dr. Alessandro De Luca, Medical Genetics Laboratory, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

Relevant Special Issue:
“Morpho-Molecular and Genetic Basis of Cardiomyopathies”
Guest Editor: Prof. Dr. Andrea Frustaci
Deadline for manuscript submissions: 30 June 2026