Cells | Highly Cited Papers Published in 2024 in the “Cell and Gene Therapy” Section

Cell gene therapy involves two aspects: cell therapy and gene therapy. Cell therapy is a method that uses the patient’s own cells or donor cells to stimulate an immune response or cell regeneration to kill pathogens and tumor cells. It includes immune cell therapy, stem cell therapy, and somatic cell therapy. Gene therapy is an approach based on treating disease by modifying (through introduction, removal, and change) the patient's genes. In recent decades, research on cell and gene therapy has developed rapidly, and this is now emerging as an alternative therapy for many diseases.

The “Cell and Gene Therapy” Section of Cells (ISSN: 2073-4409) aims to support research that focuses on the research progress of cell gene therapy in tumors, genetic diseases, cardiovascular diseases, autoimmune diseases, and certain rare diseases. We welcome original research articles, review articles, and communications on topics in this field.

You have free and unlimited access to the full texts of all of the open access articles published in our journal. We invite you to read our most highly cited papers published in 2024, which are listed below:

1. “Dual Targeting of Glioblastoma Cells with Bispecific Killer Cell Engagers Directed to EGFR and ErbB2 (HER2) Facilitates Effective Elimination by NKG2D-CAR-Engineered NK Cells”
by Anne Kiefer, Maren Prüfer, Jasmin Röder, Jordi Pfeifer Serrahima, Malena Bodden, Ines Kühnel, Pranav Oberoi and Winfried S. Wels
Cells 2024, 13(3), 246; https://doi.org/10.3390/cells13030246
Available online: https://www.mdpi.com/2073-4409/13/3/246

2. “Decorin (DCN) Downregulation Activates Breast Stromal Fibroblasts and Promotes Their Pro-Carcinogenic Effects through the IL-6/STAT3/AUF1 Signaling”
by Wafaa A. Aljagthmi, Manal A. Alasmari, Maha H. Daghestani, Layla A. Al-Kharashi, Falah H. Al-Mohanna and Abdelilah Aboussekhra
Cells 2024, 13(8), 680; https://doi.org/10.3390/cells13080680
Available online: https://www.mdpi.com/2073-4409/13/8/680

3. “Comparison of Minced Cartilage Implantation with Autologous Chondrocyte Transplantation in an In Vitro Inflammation Model”
by Robert Ossendorff, Lisa Grede, Sebastian Scheidt, Andreas C. Strauss, Christof Burger, Dieter C. Wirtz, Gian M. Salzmann and Frank A. Schildberg
Cells 2024, 13(6), 546; https://doi.org/10.3390/cells13060546
Available online: https://www.mdpi.com/2073-4409/13/6/546

4. “Synthetic mRNAs Containing Minimalistic Untranslated Regions Are Highly Functional In Vitro and In Vivo”
by Shahab Mamaghani, Rocco Roberto Penna, Julia Frei, Conrad Wyss, Mark Mellett, Thomas Look, Tobias Weiss, Emmanuella Guenova, Thomas M. Kündig, Severin Lauchli et al.
Cells 2024, 13(15), 1242; https://doi.org/10.3390/cells13151242
Available online: https://www.mdpi.com/2073-4409/13/15/1242

5. “Interaction between NSCLC Cells, CD8+ T-Cells and Immune Checkpoint Inhibitors Potentiates Coagulation and Promotes Metabolic Remodeling—New Cues on CAT-VTE”
by Catarina Freitas-Dias, Filipe Gonçalves, Filipa Martins, Isabel Lemos, Luís G. Gonçalves and Jacinta Serpa
Cells 2024, 13(4), 305; https://doi.org/10.3390/cells13040305
Available online: https://www.mdpi.com/2073-4409/13/4/305

6. “Lung Transplant Immunomodulation with Genetically Engineered Mesenchymal Stromal Cells—Therapeutic Window for Interleukin-10”
by Antti I. Nykänen, Andrea Mariscal, Allen Duong, Aadil Ali, Akihiro Takahagi, Xiaohui Bai, Guan Zehong, Betty Joe, Mamoru Takahashi, Manyin Chen et al.
Cells 2024, 13(10), 859; https://doi.org/10.3390/cells13100859
Available online: https://www.mdpi.com/2073-4409/13/10/859

7. “Allogeneic CAR-T Therapy Technologies: Has the Promise Been Met?”
by Caroline Lonez and Eytan Breman
Cells 2024, 13(2), 146; https://doi.org/10.3390/cells13020146
Available online: https://www.mdpi.com/2073-4409/13/2/146

8. “The Role of Stem Cells as Therapeutics for Ischaemic Stroke”
by Jingyuan Ya, Jessica Pellumbaj, Arshad Hashmat and Ulvi Bayraktutan
Cells 2024, 13(2), 112; https://doi.org/10.3390/cells13020112
Available online: https://www.mdpi.com/2073-4409/13/2/112

9. “Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life”
by Kemin Tan and Yuk-Ching Tse-Dinh
Cells 2024, 13(6), 553; https://doi.org/10.3390/cells13060553
Available online: https://www.mdpi.com/2073-4409/13/6/553

10. “Navigating the CRISPR/Cas Landscape for Enhanced Diagnosis and Treatment of Wilson’s Disease”
by Woong Choi, Seongkwang Cha and Kyoungmi Kim
Cells 2024, 13(14), 1214; https://doi.org/10.3390/cells13141214
Available online: https://www.mdpi.com/2073-4409/13/14/1214