The Ocular Microbiome

A special issue of Vision (ISSN 2411-5150).

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 4773

Special Issue Editors


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Guest Editor
1. Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
2. Ocular Microbiology Laboratory, Anne Bates Leach Eye Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, McKnight Research Pavilions, Rm 103A,1638 NW 10th Avenue, Miami, FL 33136, USA
3. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA
Interests: ophthalmology; ocular microbiology; keratitis; ocular infectious diseases
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Guest Editor
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA
Interests: ocular infections; conjunctivitis; keratitis; ocular surface microbiome; adults; children
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Background: The ocular surface microbiome is a complex network of microorganisms that live on the surface of the eye. Studies have shown that the microbiome is not only composed of bacteria, but also viruses, fungi and rarely protozoa. Various factors can influence these organisms, including ocular surface health, aging, contact lens wear, medications, infections and ocular surgery. Additionally, the interplay between these microorganisms, the ocular surface and invading pathogens may have important roles in disease pathophysiology.

Goal: Basic and translational research on the ocular surface microbiome, the interspecies and intraspecies interactions and host response is required in order to elucidate their roles in the health and disease of the eye.

Scope: This Special Issue will feature the diversity of the ocular surface microbial community, their interactions and impact on ocular surface homeostasis.  Authors are invited to submit original basic and translational research articles or reviews.

The conjunct Special Issue in MicroorganismsThe Ocular Microbiome

Prof. Dr. Darlene Miller
Dr. Kara Cavuoto
Guest Editors

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Published Papers (1 paper)

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Research

12 pages, 1188 KiB  
Article
Ocular Surface Microbiota in Contact Lens Users and Contact-Lens-Associated Bacterial Keratitis
by Jasmine Andersson, Josef K. Vogt, Marlene D. Dalgaard, Oluf Pedersen, Kim Holmgaard and Steffen Heegaard
Vision 2021, 5(2), 27; https://doi.org/10.3390/vision5020027 - 3 Jun 2021
Cited by 16 | Viewed by 3870
Abstract
Our objectives were to investigate whether the conjunctival microbiota is altered by contact lens wear and/or bacterial keratitis and to explore the hypothesis that commensals of conjunctival microbiota contribute to bacterial keratitis. Swab samples from both eyes were collected separately from the inferior [...] Read more.
Our objectives were to investigate whether the conjunctival microbiota is altered by contact lens wear and/or bacterial keratitis and to explore the hypothesis that commensals of conjunctival microbiota contribute to bacterial keratitis. Swab samples from both eyes were collected separately from the inferior fornix of the conjunctiva of non-contact-lens users (nparticipants = 28) and contact lens users (nparticipants = 26) and from patients with contact-lens-associated bacterial keratitis (nparticipants = 9). DNA from conjunctival swab samples was analyzed with 16S rRNA gene amplicon sequencing. Pathogens from the corneal infiltrates were identified by cultivation. In total, we identified 19 phyla and 283 genera; the four most abundant genera were Pseudomonas, Enhydrobacter, Staphylococcus, and Cutibacterium. Several pathogens related to bacterial keratitis were identified in the conjunctival microbiota of the whole study population, and the same bacteria were identified by both methods in the conjunctiva and cornea for four patients with contact-lens-associated bacterial keratitis. The overall conjunctival microbiota profile was not altered by contact lens wear or bacterial keratitis; thus, it does not appear to contribute to the development of bacterial keratitis in contact lens users. However, in some individuals, conjunctival microbiota may harbor opportunistic pathogens causing contact-lens-associated bacterial keratitis. Full article
(This article belongs to the Special Issue The Ocular Microbiome)
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