Innate Immune Activation in HIV Disease
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: closed (1 September 2021) | Viewed by 7398
Special Issue Editors
Interests: HIV; macrophage; monocyte; NK cell; signal transduction
Special Issue Information
Dear Colleagues,
An estimated 38 million people are living with HIV, and the provision of life-preserving antiretroviral medication to these individuals is increasing. Currently, HIV is a manageable, chronic health condition, and progression to AIDS is effectively prevented by antiretroviral drugs. Evidence suggests that innate immune dysfunction and inflammation remain elevated in people with HIV who achieve virologic suppression on ART and that this is associated with an increased prevalence of age-related, inflammatory comorbidities such as cardiovascular disease, frailty and neurocognitive impairment. While there is growing evidence that early treatment with ART improves outcomes for people with HIV, its effect on HIV-related inflammation and, hence, the risk of long-term inflammatory comorbidities is less clear.
This Special Issue focuses on the current evidence for innate immune dysfunction and inflammation in virologically suppressed people on ART, its possible mechanisms and causes, the impact on comorbid diseases and potential adjunctive therapeutic strategies to minimise its impact on long-term health outcomes in people with HIV.
Prof. Dr. Anthony Jaworowski
Dr. Anna C. Hearps
Guest Editors
Manuscript Submission Information
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Keywords
- HIV
- people with HIV
- inflammation
- immune dysfunction
- innate immune activation
- age-related comorbidities
- cardiovascular disease
- neurological complications
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