Function and Structure of Viral Ribonucleoproteins Complexes
A special issue of Viruses (ISSN 1999-4915).
Deadline for manuscript submissions: closed (1 August 2020) | Viewed by 58678
RNA viruses are characterized by the use of RNA as genetic material. Compared to their DNA counterparts, RNA viruses generally have smaller genomes and present a wider range of genetic diversity, due to the combined effect of a lower fidelity of replication and a higher incidence of genetic recombination. These features make RNA viruses extraordinary evolution machines. In cells, RNAs are generally associated with proteins in ribonucleic complexes (RNPs) that are in charge of addressing the RNAs to the appropriate cellular compartments and regulate their functions. To efficiently ensure viral replication, RNA genomes also associate with viral proteins to form vRNPs. These functional units are key players of the infectious cycle, driving various processes such as transcription and translation, as well as more specialized functions, including intracellular trafficking pathways for targeting viral components to assembly sites and consequently packaging viral genomic RNA into virions. Besides, determining the molecular organization and structure of vRNP is essential for unravelling the molecular mechanisms underlying the functions they are involved in. This Special Issue focuses on the interplay between viral components and aims to describe and better understand the structure and the function of RNPs in viral infection.
Dr. Serena Bernacchi
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- viral proteins
- viral RNA
- ribonucleoproteins complexes
- viral replication