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How HIV-1 Gag Manipulates Its Host Cell Proteins: A Focus on Interactors of the Nucleocapsid Domain

INSERM UMR_S 1109, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Université de Strasbourg, 67000 Strasbourg, France
UMR 7021, CNRS, Laboratoire de Bioimagerie et Pathologies, Université de Strasbourg, Faculté de Pharmacie, 67400 Illkirch, France
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2020, 12(8), 888;
Received: 13 July 2020 / Revised: 6 August 2020 / Accepted: 10 August 2020 / Published: 13 August 2020
(This article belongs to the Special Issue Function and Structure of Viral Ribonucleoproteins Complexes)
The human immunodeficiency virus (HIV-1) polyprotein Gag (Group-specific antigen) plays a central role in controlling the late phase of the viral lifecycle. Considered to be only a scaffolding protein for a long time, the structural protein Gag plays determinate and specific roles in HIV-1 replication. Indeed, via its different domains, Gag orchestrates the specific encapsidation of the genomic RNA, drives the formation of the viral particle by its auto-assembly (multimerization), binds multiple viral proteins, and interacts with a large number of cellular proteins that are needed for its functions from its translation location to the plasma membrane, where newly formed virions are released. Here, we review the interactions between HIV-1 Gag and 66 cellular proteins. Notably, we describe the techniques used to evidence these interactions, the different domains of Gag involved, and the implications of these interactions in the HIV-1 replication cycle. In the final part, we focus on the interactions involving the highly conserved nucleocapsid (NC) domain of Gag and detail the functions of the NC interactants along the viral lifecycle. View Full-Text
Keywords: HIV-1; Gag; Pr55Gag; interactants; NCp7; nucleocapsid HIV-1; Gag; Pr55Gag; interactants; NCp7; nucleocapsid
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Klingler, J.; Anton, H.; Réal, E.; Zeiger, M.; Moog, C.; Mély, Y.; Boutant, E. How HIV-1 Gag Manipulates Its Host Cell Proteins: A Focus on Interactors of the Nucleocapsid Domain. Viruses 2020, 12, 888.

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