Flavivirus Vaccines

Dear Colleagues,

Flaviviruses consist of diverse group of pathogens responsible for hundreds of millions of human infections annually. While there are highly effective vaccines to certain flaviviruses, such as Yellow Fever Virus, other Flavivirus vaccines are largely in developmental stages. Many factors may govern natural infection clearance or vaccine effectiveness, including but not limited to the initiation of immune responses at the site of infection, the time between exposures to vaccines or natural infections, and the vaccine composition. Due to their close antigenic relationships, flaviviruses evoke immune responses that are cross-reactive, and this presents complex challenges for vaccine development. These cross-reactive immune responses could potentially be pathogenic or may provide Flavivirus cross-protection. In this Special Issue, we will highlight advances in Flavivirus vaccine development and in the understanding of host immune responses that can inform vaccine design. We also welcome research that will broaden our understanding of Flavivirus cross-reactive immune responses.

Dr. Ashley L. St. John
Dr. Abhay P.S. Rathore
Guest Editors

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