Antibody-Based Therapeutics and Diagnostics for Viral Diseases
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 11393
Special Issue Editor
Interests: cancer immunotherapy; chimeric antigen receptor T cells; bispecific antibodies; single domain antibody; virus therapy and diagnosis
Special Issue Information
Dear Colleagues,
Monoclonal antibodies (mAbs) are useful tools for the diagnosis and treatment of a variety of viral diseases induced by pre-existing and/or emerging viruses, including SARS-CoV, MERS, SARS-CoV-2, and HIV. Traditionally, the consecutive processes of immunization and hybridoma technology to produce a hybrid cell have been used to identify and overproduce target-specific mAbs. Recent advances in recombinant DNA technology have enabled antibody humanization, the generation of human naïve or synthetic antibody libraries, phage display antibody selection, and overproduction of phage-display-derived mAbs. Currently, despite the recent development of various antibody-based therapeutics and diagnostics for viral diseases, the accumulation of high-frequency mutations in viruses has often weakened the virus neutralization and detection activity of existing viral-protein-specific mAbs. In this Special Issue, we focus on covering novel antibody-based diagnostics and therapeutics including antibodies, nanobodies, aptamers, peptides, and Fc-fusion proteins for timely measures and effective management against viral diseases.
Prof. Dr. Sukmook Lee
Guest Editor
Manuscript Submission Information
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Keywords
- monoclonal antibody
- bi-/multi-specific antibody
- therapeutics
- diagnostics
- coronaviruses including SEAR-CoV, MERS-CoV, and SARS-CoV-2
- viral diseases
- platform technology
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