The Life Cycle of Human Papillomaviruses
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 48
Special Issue Editor
Interests: papillomavirus; virus tropsim; cervical cancer; tumour viruses; cervical screening
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Papillomaviruses complete their life cycle at differentiating epithelial sites, and have evolved mechanisms of gene control that allow them to produce infectious particles towards the surface of infected skin.To do this they quietly persist in the epithelial basal cells, where their genome is maintained as a low copy number episome, and where viral gene expression mediates subtle changes in epithelial homeostasis. Virus production in the upper epithelial layers requires regulated changes in viral gene expression. Human papillomaviruses have become expert modulators of the epithelial tissue that they infect, with their proteins having a remarkable range of functions to achieve this end and to ensure that infection is not readily detected by the host immune system. These functions, when deregulated, can drive neoplasia and the development of cancer, which occurs at particular vulnerable body sites, including the oropharynx and the anal and cervical transformation zones. This Special Issue aims to showcase our current understanding of the human papillomavirus life cycle, the regulatory factors that are involved in life cycle control, and the deregulation that may eventually lead to cancer.
Prof. Dr. John Doorbar
Guest Editor
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Keywords
- human papillomavirus (HPV)
- viral life cycle
- epithelial differentiation
- gene expression regulation
- oncogenesis
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