Inflammatory and Degenerative Disorders in Veterinary Medicine: Molecular Mechanisms, Diagnosis, and Therapeutic Strategies

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 11 November 2026 | Viewed by 156

Special Issue Editors


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Guest Editor
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China
Interests: osteoarthritis; inflammation mechanism; therapeutic drugs
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
Interests: degenerative diseases; cartilage repair; phytotherapy; regenerative medicine

Special Issue Information

Dear Colleagues,

This Special Issue on "Inflammatory and Degenerative Disorders in Veterinary Medicine: Molecular Mechanisms, Diagnosis, and Therapeutic Strategies" aims to provide a comprehensive, multidisciplinary platform spanning three interconnected domains: (1) mechanistic investigations into disease pathogenesis; (2) advances in diagnostic methodologies from proteomic biomarker discovery to early indicators of metabolic dysfunction, and (3) innovative therapeutic strategies ranging from targeted immunomodulators to mesenchymal stem cell-based regenerative approaches. By encompassing studies across companion animals, livestock, and equine patients, this Special Issue seeks to foster comparative insights that advance understanding of disease biology and inform translational applications.

Inflammatory and degenerative diseases are not only prominent topics in the field of veterinary medicine but also unresolved challenges in human medicine. A range of degenerative conditions, primarily affecting the musculoskeletal and nervous systems, particularly impact racehorses and older dogs and cats, and the chronic pain associated with these diseases remains incompletely understood. There are numerous underlying connections between inflammatory and degenerative diseases. For instance, at the molecular level of pathogenesis, both involve pathways such as cell death, oxidative stress, and cellular senescence, leading to overlapping therapeutic strategies. However, given the heterogeneity of these diseases, precise subtyping and targeted treatment represent the current approach to therapy. Furthermore, in the diagnosis of inflammatory and degenerative diseases, the identification of early biomarkers is essential for prediction and prevention. This Special Issue aims to publish the latest research in veterinary medicine, with a particular emphasis on naturally occurring cases, thereby providing enhanced guidance for practitioners and researchers alike.

Dr. Hui Bai
Dr. Tianwen Ma
Guest Editors

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Keywords

  • veterinary medicine
  • inflammatory diseases
  • degenerative diseases
  • animal diseases
  • pathogenesis
  • disease mechanisms
  • diagnostic methods
  • biomarkers
  • therapeutics
  • preventive measures
  • immunology
  • oxidative stress
  • apoptosis (cell death)
  • comparative medicine
  • translational research
  • phytotherapy
  • regenerative medicine
  • canine
  • feline
  • bovine
  • porcine
  • equine medicine

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Published Papers (1 paper)

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Research

12 pages, 2766 KB  
Article
Combined PRP and CCP Therapy Suppresses Inflammation and Protects Cartilage in Post-Traumatic Osteoarthritis
by Tianwen Ma, Yongti Liu, Yanan Li, Hui Bai, Xiaxin Liu, Zongsheng Qiu, Yuhui Ma, Hai Li and Baoming Shi
Vet. Sci. 2026, 13(6), 506; https://doi.org/10.3390/vetsci13060506 - 22 May 2026
Abstract
This study aimed to evaluate the therapeutic effects of platelet-rich plasma (PRP) and Cervus and Cucumis polypeptide (CCP) injections in rats with post-traumatic osteoarthritis (OA). The model was established by transection of the anterior cruciate ligament, and the animals were subsequently treated with [...] Read more.
This study aimed to evaluate the therapeutic effects of platelet-rich plasma (PRP) and Cervus and Cucumis polypeptide (CCP) injections in rats with post-traumatic osteoarthritis (OA). The model was established by transection of the anterior cruciate ligament, and the animals were subsequently treated with PRP and CCP. Articular cartilage degeneration was assessed through gross morphological observation, histopathological staining, and a standardized scoring system. Concurrently, pain-related behaviors, joint swelling, levels of inflammatory cytokines, and markers associated with extracellular matrix degradation were measured. The results demonstrated that, compared with the OA model group, PRP and CCP exhibited varying degrees of functional improvement, specifically, a reduction in pain-related behaviors and an alleviation of joint swelling. Furthermore, cartilage morphological damage was diminished, inflammatory marker levels decreased, and indicators of extracellular matrix degradation were attenuated. Histopathological examination of liver and kidney tissues revealed no apparent abnormalities. This study provides valuable experimental evidence for further treatment strategies for OA. Full article
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