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TropicalMed
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Viral Hepatitis and Other Microbial Threats in Tropical Medicine
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Viral Hepatitis and Other Microbial Threats in Tropical Medicine

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Infectious Diseases".

Deadline for manuscript submissions: 10 July 2026 | Viewed by 2791

Special Issue Editor

Dr. Isaac Thom Shawa

E-Mail Website
Guest Editor
School of Human Science, University of Derby, Kedleston Road Campus, Derby DE22 1GB, UK
Interests: medical microbiology; virology; hepatitis; COVID-19

Special Issue Information

Dear Colleagues,

“Viral Hepatitis and Other Microbial Threats in Tropical Medicine” provides a comprehensive overview of the current landscape of viral hepatitis and other significant microbial challenges in tropical and subtropical regions. While viral hepatitis continues to impose a substantial global health burden, this Special Issue expands its scope to include a wide range of microbial threats, including viral, bacterial, parasitic, and fungal threats that are prevalent in tropical regions.

Key topics will include advances in diagnosing and treating viral hepatitis; developing novel antiviral and antimicrobial agents; applying innovative diagnostic tools, such as rapid diagnostic tests, molecular assays, and dried blood spots; and addressing the emergence of new or re-emerging infectious agents. There will also be a central focus on antimicrobial resistance (AMR), a growing concern in tropical medicine. This focus will explore the drivers of AMR, surveillance strategies, and their implications for clinical management and public health policy.

Additional areas of interest include neglected tropical diseases, zoonotic infections, the impact of environmental and socioeconomic factors, and health system challenges specific to low-resource tropical regions. The Special Issue will also explore how climate change, urbanization, and population mobility contribute to the evolving microbial landscape.

This Special Issue brings together cutting-edge research, clinical perspectives, and epidemiological studies to highlight both achievements and ongoing challenges in the fight against microbial threats in tropical medicine. The Issue seeks to inform global strategies aimed at reducing disease burden, combating antimicrobial resistance, and addressing health inequities in some of the world's most vulnerable populations.

Dr. Isaac Thom Shawa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tropical Medicine and Infectious Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viral hepatitis
  • pentavalent vaccine
  • molecular diagnostics
  • disease diagnosis
  • genotypes and sub-genotypes
  • immune responses
  • liver cancer
  • hepatocellular carcinoma
  • human pegivirus
  • antiviral therapy
  • public health
  • epidemiology

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Published Papers (2 papers)

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Research

17 pages, 4045 KB  
Article
Global Temporal Trends and Projections of Acute Hepatitis E Epidemiology for Adults 65 Years and Older from 1990 to 2021: Global Burden of Disease 2021 Based Study
by Shuangshuang Ma, Qingling Wang, Junjie Lin and Yufeng Gao
Trop. Med. Infect. Dis. 2026, 11(3), 82; https://doi.org/10.3390/tropicalmed11030082 - 17 Mar 2026
Viewed by 791
Abstract
Background: Acute hepatitis E (AHE) poses escalating risks to older adults (≥65 years), compounded by immunosenescence and comorbidities. Using Global Burden of Disease (GBD) 2021 data, this study analyzes global AHE burden, trends, and projections in aging populations. Methods: Age-standardized rates (ASIR, ASMR, [...] Read more.
Background: Acute hepatitis E (AHE) poses escalating risks to older adults (≥65 years), compounded by immunosenescence and comorbidities. Using Global Burden of Disease (GBD) 2021 data, this study analyzes global AHE burden, trends, and projections in aging populations. Methods: Age-standardized rates (ASIR, ASMR, ASDR) for AHE in adults ≥ 65 years were extracted from GBD 2021 across 204 countries (1990–2021). Frontier analysis assessed gaps between observed burdens and sociodemographic index (SDI)-based theoretical minima. Age-period-cohort (APC) modeling evaluated age/period/cohort effects. Bayesian (BAPC), NORDPRED, and ARIMA models projected trends to 2050. Results: Global ASIR increased by 1.5% annually (1990–2021), with ASMR and DALYs declining significantly. Middle SDI regions showed the steepest ASIR rise (net drift: 0.064%/year), while high SDI areas had volatile trends. Age effects peaked in ≥95-year-olds. Frontier analysis revealed persistent ASIR-SDI gaps, particularly in low-middle SDI regions. Projections indicate a ASIR rise by 2050 (113.04/100,000), contrasting with declining ASMR (0.056/100,000) and ASDR (1.31/100,000) and the NORDPRED, ARIMA, and EAPC models exhibit analogous global predictive trends. Conclusions: Diverging trends of rising incidence and falling mortality highlight unmet prevention needs. High-burden regions require SDI-stratified strategies, prioritizing vaccination programs (e.g., HEV 239), zoonotic transmission control, and enhanced surveillance. The Sustainable Development Goals (SDGs) envision hepatitis elimination by 2030 (Target 3.3). However, our analysis projects ongoing AHE burden in aging populations through 2050, indicating the need for post-2030 policy adaptations. Full article
(This article belongs to the Special Issue Viral Hepatitis and Other Microbial Threats in Tropical Medicine)
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10 pages, 797 KB  
Article
Prevalence and Screening Rates of Hepatitis B and Hepatitis C Infections in Adult Patients with Solitary Organ Tumors
by Seyhmus Abakay, Hüseyin Döngelli, Nilay Danış, Halil İbrahim Ellez, Göksel Bengi, Tuğba Yavuzşen and Hüseyin Salih Semiz
Trop. Med. Infect. Dis. 2025, 10(9), 258; https://doi.org/10.3390/tropicalmed10090258 - 10 Sep 2025
Viewed by 1268
Abstract
Background and Aims: Hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) remain significant global public health issues despite advances in their diagnosis and treatment. Our country is in a medium endemic region for HBV. Reactivation can occur during [...] Read more.
Background and Aims: Hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) remain significant global public health issues despite advances in their diagnosis and treatment. Our country is in a medium endemic region for HBV. Reactivation can occur during or after immunosuppressive therapy. Therefore, screening patients before treatment is crucial to prevent reactivation. However, pretreatment screening is often insufficiently emphasized in studies. This study aimed to assess the incidence of HBV and pretreatment screening rates in patients with solid organ tumors at our center. Methods: We included patients aged over 18 years who were treated for solid organ tumors at our center between January 2016 and January 2022. Data on age, sex, histopathological diagnosis, and serological parameters were retrospectively collected. Appropriate HBV screening was defined as the assessment of HBsAg, anti-HBs, and anti-HBc IgG levels prior to the initiation of immunosuppressive therapy. Results: In our study, HBsAg testing was requested for 13.3% of the patients, and anti-HCV testing was requested for 13.3%. Among the patients screened for HBV and HCV, the prevalence rates of HBV and HCV infection were 3.3% and 1%, respectively. Conclusions: Our findings reveal inadequate screening rates for HBV and HCV among patients receiving immunosuppressive therapy. Increasing awareness about screening and implementing regular educational programs are crucial to protect patients from reactivation. Full article
(This article belongs to the Special Issue Viral Hepatitis and Other Microbial Threats in Tropical Medicine)
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