Bioinformatics On the Quest for New Antileishmanial Drugs
A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366).
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 8185
Special Issue Editor
Special Issue Information
Dear Colleagues,
Leishmaniasis is caused by parasites of the genus Leishmania (Kinetoplastida, Trypanosomatidae), where roughly 20 parasite species can infect mammals and many of them can lead to human disease. Around 380 million people are at risk for leishmaniasis in 98 countries, and from 1.5 to 2.0 million cases are reported each year, with a significant morbidity and fatality rate. For human use, no vaccine is yet available, and current chemotherapy has several harmful side effects. It is still difficult to transform new research into cost-efficient and accessible biotechnology solutions that attempt to manage and/or enhance the conditions of the disease's therapy. Although new approaches and advancements in antileishmanial drug research are needed for new therapeutic candidates, the biggest obstacles to this goal's success depend on worldwide contributions. Drug discovery and development now heavily rely on bioinformatic methods, which can also lead to quicker, safer, and less expensive drug advancement. Both the pharmaceutical industry and academia rely on in silico drug discovery and development, which has been also focused on new therapeutics against leishmaniasis. While encouraging studies that are followed by in vitro and/or in vivo validation, we invite authors to submit original research articles presenting bioinformatic analysis applied to develop potential novel therapeutics against leishmaniasis.
Potential topics include but are not limited to:
- Nanotechnology-based formulation;
- Molecular docking and molecular dynamics simulations;
- Omics data for new target selection;
- Virtual screening.
Dr. Miguel Angel Chávez-Fumagalli
Guest Editor
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Keywords
- bioinformatics
- drug targets
- drug discovery
- virtual screening
- molecular docking
- pharmacogenomics
- pharmacogenetics
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