Natural Compounds’ Mitigation of Toxicity: Insights into Health Protection
A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicity Reduction and Environmental Remediation".
Deadline for manuscript submissions: 10 January 2026 | Viewed by 27
Special Issue Editors
Interests: endocrine disruptors; medicinal plants; toxicology; reproductive toxicology; teratology; brain sexual differentiation; environmental health
Special Issue Information
Dear Colleagues,
Natural compounds have emerged as promising candidates to counteract the harmful effects of environmental and xenobiotic toxicants. These bioactive molecules, often derived from plants, fungi, or marine organisms, exhibit diverse pharmacological properties, including antioxidant, anti-inflammatory, antimicrobial, anticancer, antiaging, antiviral, immunomodulatory, and detoxifying activities. Phytochemicals present in natural compounds can attenuate oxidative stress, modulate xenobiotic-metabolizing enzymes, and help maintain cellular homeostasis. Additionally, several compounds have demonstrated protective effects in experimental models of heavy metal-induced nephrotoxicity, pesticide-induced neurotoxicity, reproductive toxicity, and drug-induced hepatotoxicity. Beyond their cellular protective functions, natural compounds have also been shown to modulate epigenetic mechanisms, reduce DNA damage, and enhance mitochondrial function, further supporting their chemopreventive potential.
With growing concerns about environmental and chemical toxicity, integrative approaches combining conventional and natural therapies are increasingly relevant. Advancing research in this field is essential to identify efficacious, low-toxicity biointerventions that complement standard treatments. Ongoing studies into the molecular, cellular, and systemic mechanisms underlying natural compounds’ protective actions may foster novel prophylactic and therapeutic strategies in toxicology, pharmacognosy, and environmental health sciences.
For this Special Issue, we invite manuscripts exploring the mitigating effects of natural substances on toxicological outcomes, emphasizing therapeutic potential and translational relevance. Submissions may include original research articles, reviews, and short communications.
Dr. Arielle Cristina Arena
Prof. Dr. Cândida Aparecida Leite Kassuya
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- natural compounds
- toxicity mitigation
- phytochemicals
- oxidative stress
- xenobiotic metabolism
- chemoprevention
- environmental toxicants
- protective mechanisms
- integrative therapies
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