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Toxics
Special Issues
Evaluating DNA Damage and Toxicological Effects
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Evaluating DNA Damage and Toxicological Effects

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".

Deadline for manuscript submissions: 10 February 2026 | Viewed by 1409

Special Issue Editors

Prof. Dr. Natalia Tretyakova

E-Mail Website
Guest Editor
Department of Medicinal Chemistry, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Interests: DNA damage and repair; epigenetics; cancer; aging; nucleosides; medicinal chemistry; protein and DNA biomarkers; proteomics
Dr. Deyu Li

E-Mail Website
Guest Editor
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA
Interests: the formation of DNA lesions and subsequent mutations; tumor development; carcinogens; molecular inhibitors such as Nitric Oxide and oncometabolites to certain DNA repair enzymes; mutational spectra of bulky DNA lesions; inhibitory effect of nitric oxide on DNA repair enzymes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human genome is constantly challenged by endogenous and exogenous electrophiles that form potentially toxic and mutagenic DNA adducts. This Special Issue will discuss the role of DNA damage in aging and cancer, focusing on adduct structures, detection methods, and their biological and toxicological outcomes. We will review DNA lesions generated from endogenous reactive species and exogenous damaging agents, including environmental toxins and chemotherapeutic drugs. For detection methods, we will cover various techniques including LC-MS, antibody-based methods, and NMR. For biological outcomes of DNA adducts, we will consider toxicological effects, chemical reactivity, mutagenicity, and toxicity. We will also discuss DNA repair mechanisms. Overall, this Special Issue will review the latest advancements in DNA adducts and their toxicological effects.

Prof. Dr. Natalia Tretyakova
Dr. Deyu Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • DNA damage
  • DNA repair
  • toxicological effect
  • nucleic acid biomarker
  • DNA adduct

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Published Papers (1 paper)

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Research

16 pages, 1814 KB  
Article
Strain and Sex Variability in Liver, Kidney and Lung Levels of DNA Adducts EB-GII and bis-N7G-BD Following Inhalation Exposure to 1,3-Butadiene in Collaborative Cross Mice
by Erik Moran, Samantha Goodman, Fred A. Wright, Richard Evans, Natalia Y. Tretyakova and Ivan Rusyn
Toxics 2025, 13(10), 844; https://doi.org/10.3390/toxics13100844 - 3 Oct 2025
Viewed by 1235
Abstract
1,3-butadiene (BD) is a volatile organic pollutant. Upon inhalation, it is metabolically activated to reactive epoxides which alkylate genomic DNA and form potentially mutagenic monoadducts and DNA–DNA crosslinks including N7-(1-hydroxyl-3-buten-1-yl)guanine (EB-GII) and 1,4-bis-(guan-7-yl)-2,3-butanediol (bis-N7G-BD). While metabolic activation resulting in [...] Read more.
1,3-butadiene (BD) is a volatile organic pollutant. Upon inhalation, it is metabolically activated to reactive epoxides which alkylate genomic DNA and form potentially mutagenic monoadducts and DNA–DNA crosslinks including N7-(1-hydroxyl-3-buten-1-yl)guanine (EB-GII) and 1,4-bis-(guan-7-yl)-2,3-butanediol (bis-N7G-BD). While metabolic activation resulting in mutagenicity is a well-established mode of action for 1,3-butadiene, characterization of the extent of inter-individual variability in response to BD exposure is a gap in our knowledge. Previous studies showed that population-wide mouse models can be used to evaluate variability in 1,3-butadiene DNA adducts; therefore, we hypothesized that this approach can be used to also study variability in the formation and loss of BD DNA adducts across tissues and between sexes. To test this hypothesis, female and male mice from five genetically diverse Collaborative Cross (CC) strains were exposed to filtered air or 1,3-butadiene (600 ppm, 6 h/day, 5 days/week for 2 weeks) by inhalation. Some animals were kept for two additional weeks after exposure to study DNA adduct persistence. EB-GII and bis-N7G-BD adducts were quantified in liver, lungs and kidney using established isotope dilution ESI-MS/MS methods. We observed strain- and sex-specific effects on both the accumulation and loss of both DNA adducts, indicating that both factors play important roles in the mutagenicity of 1,3-butadiene. In addition, we quantified the intra-species variability for each adduct and found that for most tissues/adducts, variability values across strains were modest compared to default uncertainty factors. Full article
(This article belongs to the Special Issue Evaluating DNA Damage and Toxicological Effects)
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