Evaluating DNA Damage and Toxicological Effects

Dear Colleagues,

The human genome is constantly challenged by endogenous and exogenous electrophiles that form potentially toxic and mutagenic DNA adducts. This Special Issue will discuss the role of DNA damage in aging and cancer, focusing on adduct structures, detection methods, and their biological and toxicological outcomes. We will review DNA lesions generated from endogenous reactive species and exogenous damaging agents, including environmental toxins and chemotherapeutic drugs. For detection methods, we will cover various techniques including LC-MS, antibody-based methods, and NMR. For biological outcomes of DNA adducts, we will consider toxicological effects, chemical reactivity, mutagenicity, and toxicity. We will also discuss DNA repair mechanisms. Overall, this Special Issue will review the latest advancements in DNA adducts and their toxicological effects.

Prof. Dr. Natalia Tretyakova
Dr. Deyu Li
Guest Editors

Manuscript Submission Information

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