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Toxics
Special Issues
Harmful Outcomes of Environmental and Food Pollutants on Human Health
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Harmful Outcomes of Environmental and Food Pollutants on Human Health

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Agrochemicals and Food Toxicology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 157

Special Issue Editor

Dr. Wei Mu

E-Mail Website
Guest Editor
School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
Interests: exposomics and toxicology; adverse outcome pathway (AOP); Immunotoxicology; exosome and celluar crosstalk

Special Issue Information

Dear Colleagues,

The Special Issue, “Harmful Outcomes of Environmental and Food Pollutants on Human Health”, highlights the “Exposome Analysis and Risk Assessment Section” of multiomics, machine learning, and immunotoxicology. It examines pollutants' molecular and systemic effects on health, focusing on immune responses and signal transduction in microenvironments.

Research Areas: Exposomics and Toxicology: Using genomics, proteomics, and metabolomics to uncover biomarkers of pollutant exposure and effects on cellular health.

Toxicology and Immune Impact: Insights into the immune–toxicological profiles of heavy metals, persistent organic pollutants, and nanoparticles.

Gut-Human Crosstalk: Analysis of pollutants' effects on human microbiomes and related health risks.

Epigenetic and Intergenerational Effects: Exploring heritable epigenetic changes from pollutants.

Advanced Toxicology Techniques: Employing high-resolution mass spectrometry and single-cell sequencing to pinpoint toxicological pathways.

Dr. Wei Mu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exposomics and toxicology
  • immunotoxicology
  • adverse outcome pathway (AOP)
  • microenvironment
  • alternative testing methods in toxicology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

18 pages, 2975 KiB  
Article
Benzo[a]pyrene-Induced Developmental Toxicity in Caenorhabditis elegans: Potential Involvement of Insulin/IGF Signaling and Collagen Gene Dysregulation
by Jinjin Zhou, Yage Shi, Yanfeng Zhou and Yang Ge
Toxics 2025, 13(5), 384; https://doi.org/10.3390/toxics13050384 - 9 May 2025
Abstract
Benzo[a]pyrene (B[a]P) is a widespread and persistent organic pollutant that poses serious threats to human health. Although its carcinogenic properties have been extensively studied, its developmental toxicity and underlying mechanisms remain poorly understood. In this study, we employed Caenorhabditis elegans (C. elegans [...] Read more.
Benzo[a]pyrene (B[a]P) is a widespread and persistent organic pollutant that poses serious threats to human health. Although its carcinogenic properties have been extensively studied, its developmental toxicity and underlying mechanisms remain poorly understood. In this study, we employed Caenorhabditis elegans (C. elegans) as a model organism to investigate the effects of B[a]P exposure during early developmental stages. To comprehensively assess B[a]P-induced developmental toxicity, we employed high-throughput sequencing along with transgenic and mutant C. elegans strains. Exposure to B[a]P at concentrations exceeding 1 mg/L significantly reduced larval body size, decreased the number of adult worms, and delayed larval-to-adult development. Furthermore, we analyzed the expression of genes involved in cuticle collagen synthesis and key components of the insulin/insulin-like growth factor signaling (IIS) pathway, including daf-2 and daf-16. These findings suggest that B[a]P-induced developmental toxicity may be associated with dysregulation of the IIS pathway. Specifically, B[a]P appears to influence the activity of the downstream transcription factor daf-16, thereby altering the expression of collagen-related genes. This disruption in collagen synthesis may contribute to delayed larval development and impaired maturation. Our study provides new insights into the environmental hazards associated with B[a]P exposure and reveals a potential mechanism underlying its developmental toxicity. Moreover, our findings highlight the critical role of collagen gene regulation during early developmental stages. These genes may serve as potential biomarkers for environmental toxicant exposure, particularly in vulnerable populations such as children undergoing critical periods of development. Full article
(This article belongs to the Special Issue Harmful Outcomes of Environmental and Food Pollutants on Human Health)
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