Nanoparticle- and Cell-Specific Toxicological Mechanisms

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Novel Methods in Toxicology Research".

Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 2233

Special Issue Editor

California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, USA
Interests: nanotoxicology; nanoEHS; nano-bio-interface; nanotherapeutics; vaccine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue "Nanoparticle- and Cell-Specific Toxicological Mechanisms" is focused on advancing our understanding of the toxicity of nanomaterials at a cellular level. This issue aims to provide a comprehensive overview of the current knowledge and state-of-the-art research on the toxicity and the interaction mechanisms of nanomaterials with cells.

This Special Issue is to bring together researchers and experts in the field to discuss the latest advancements, trends, and challenges in research, including but not limited to nanoparticle structure–activity relationships, emerging hazardous pollutant particles at nanoscale (such as wildfire dusts, nanosized 3D printing emissions and nanoplastics, etc.), and new methodologies and technologies. This issue will build on and extend current knowledge on the toxicity of nanomaterials by incorporating new perspectives and insights from recent research. The purpose of this issue is to provide an up-to-date and comprehensive resource for researchers, practitioners, policy makers, and the general public, and to help to further our understanding of the mechanisms behind nanomaterial toxicity.

Dr. Xiang Wang
Guest Editor

Manuscript Submission Information

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Keywords

  • nanomaterials
  • toxicity
  • cellular
  • mechanisms
  • structure–activity relationships
  • emerging hazardous pollutant particles
  • new methodologies and technologies

Published Papers (2 papers)

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Research

16 pages, 2552 KiB  
Article
Silver Nanoparticles Decorated with Curcumin Enhance the Efficacy of Metformin in Diabetic Rats via Suppression of Hepatotoxicity
by Iftekhar Hassan, Jameel Al-Tamimi, Hossam Ebaid, Mohamed A. Habila, Ibrahim M. Alhazza and Ahmed M. Rady
Toxics 2023, 11(10), 867; https://doi.org/10.3390/toxics11100867 - 18 Oct 2023
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Abstract
Hepatotoxicity is one of the significant side effects of chronic diabetes mellitus (DM) besides nephrotoxicity and pancreatitis. The management of this disease is much dependent on the restoration of the liver to its maximum functionality, as it is the central metabolic organ that [...] Read more.
Hepatotoxicity is one of the significant side effects of chronic diabetes mellitus (DM) besides nephrotoxicity and pancreatitis. The management of this disease is much dependent on the restoration of the liver to its maximum functionality, as it is the central metabolic organ that gets severely affected during chronic diabetes. The present study investigates if the silver nanoparticles decorated with curcumin (AgNP-Cur) can enhance the efficacy of metformin (a conventional antidiabetic drug) by countering the drug-induced hepatoxicity. Swiss albino rats were categorized into six treatment groups (n = 6): control (group I without any treatment), the remaining five groups (group II, IV, V, VI) were DM-induced by streptozocin. Group II was untreated diabetic positive control, whereas groups III was administered with AgNP-cur (5 mg/kg). Diabetic group IV treated with metformin while V and VI were treated with metformin in a combination of the two doses of NPs (5 and 10 mg/kg) according to the treatment schedule. Biochemical and histological analysis of blood and liver samples were conducted after the treatment. The groups V and VI treated with the combination exhibited remarkable improvement in fasting glucose, lipid profile (HDL and cholesterol), liver function tests (AST, ALT), toxicity markers (GGT, GST and LDH), and redox markers (GSH, MDA and CAT) in comparison to group II in most of the parameters. Histological evaluation and comet assay further consolidate these biochemical results, pleading the restoration of the cellular structure of the target tissues and their nuclear DNA. Therefore, the present study shows that the NPs can enhance the anti-diabetic action by suppression of the drug-mediated hepatoxicity via relieving from oxidative stress, toxic burden and inflammation. Full article
(This article belongs to the Special Issue Nanoparticle- and Cell-Specific Toxicological Mechanisms)
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13 pages, 3194 KiB  
Article
Three-Dimensional Mass Transfer Modeling of Hydroquinone Adsorption on Phragmites australis Biochar
by Shengli Shi, Aiguo Luo, Jianwei Hao, Shulian Xie and Jia Feng
Toxics 2023, 11(7), 639; https://doi.org/10.3390/toxics11070639 - 23 Jul 2023
Viewed by 772
Abstract
In this work, the overall adsorption kinetic process of hydroquinone on Phragmites australis biochar (PAC) was analyzed in depth. A 3D mass transfer model of pore volume and surface diffusion was established, and the diffusion mechanism was analyzed. The characterization results show PAC [...] Read more.
In this work, the overall adsorption kinetic process of hydroquinone on Phragmites australis biochar (PAC) was analyzed in depth. A 3D mass transfer model of pore volume and surface diffusion was established, and the diffusion mechanism was analyzed. The characterization results show PAC has a higher porosity value, which is conducive to the adsorption of hydroquinone. The adsorption process modeling results show that the combined effect of pore volume diffusion and surface diffusion promotes the total diffusion process of hydroquinone in the PAC particles, and the two mechanisms of pore volume and surface diffusion exist simultaneously. Under the different operating concentrations, the range of surface diffusion coefficient Ds is 2.5 × 10−10–1.74 × 10−9 cm2/s, and the contribution rate of surface diffusion SDCP% is close to 100%, which is much larger than pore volume diffusion, revealing that regardless of the contact time and position, surface diffusion occupies the main position in intraparticle diffusion. Full article
(This article belongs to the Special Issue Nanoparticle- and Cell-Specific Toxicological Mechanisms)
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