Association Between Environmental Pollutants Exposures and Chronic Disease

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 1009

Special Issue Editor


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Guest Editor
School of Life Science, Shanxi University, Taiyuan 030006, China
Interests: environmental risk assessment; health promotion; chronic disease intervention; statistical modeling; causal inference

Special Issue Information

Dear Colleagues,

This Special Issue aims to explore the relationship between exposure to environmental pollutants and chronic diseases, with a focus on the growing problem of environmental pollution worldwide and its significant impact on public health. As urbanization accelerates and industrial emissions increase, the concentration of environmental exposures—such as those in air, water, and soil—continues to rise, posing serious challenges to human health. Numerous studies indicate that long-term exposure to environmental pollutants, including fine particulate matter (PM2.5), harmful chemicals (such as heavy metals and pesticides), toxic gases (such as sulfur dioxide and nitrogen oxides), and potential affecting indicators (such as traffic noise, greenness exposure, and exposure to artificial light sources at night), is closely associated with the onset and progression of various chronic diseases and further related mental health, including cardiovascular diseases, respiratory diseases, diabetes, cancer, and induced mental health.

This Special Issue will examine the potential mechanisms through which environmental exposure affects chronic diseases and its induced mental health, present epidemiological evidence, and investigate the relationship between early exposure and disease development. It will also explore the effects of various pollutants on multiple biomarkers of chronic diseases and discuss intervention strategies. Additionally, this Special Issue will highlight innovative advances in pollution exposure assessment methods, particularly their application in high-risk populations and their implications for public health. By reviewing existing literature and compiling cutting-edge research, this Special Issue aims to provide the latest scientific data and analysis for academia, public health, and policymakers; promote research advancements in related fields; and offer theoretical support for the development of effective environmental pollution control and health protection policies.

Prof. Dr. Fei Wang
Guest Editor

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Keywords

  • environmental pollutant and exposure effects
  • chronic diseases
  • epidemiological effects
  • induced health effects
  • public health
  • toxic effects
  • biological mechanism

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Published Papers (1 paper)

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Research

16 pages, 913 KB  
Article
Association of Serum Organophosphorus Pesticide Levels with T2D Risk and Blood Glucose Changes: A Nested Case–Control Study
by Yan Yan, Chengyong Jia, Xu Cheng, Jun An, Peiwen Li, Jiazhen Zhang, Weiya Li and Meian He
Toxics 2026, 14(4), 283; https://doi.org/10.3390/toxics14040283 - 26 Mar 2026
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Abstract
Organophosphorus pesticides (OPs) are widely used in agriculture, but prospective studies on their chronic exposure and risk of type 2 diabetes (T2D) and glucose metabolism disorders are scarce. Most previous studies focused on agricultural workers and relied on questionnaires or urinary metabolites for [...] Read more.
Organophosphorus pesticides (OPs) are widely used in agriculture, but prospective studies on their chronic exposure and risk of type 2 diabetes (T2D) and glucose metabolism disorders are scarce. Most previous studies focused on agricultural workers and relied on questionnaires or urinary metabolites for exposure assessment. We conducted a nested case–control study with 1006 pairs of participants based on the Dongfeng–Tongji cohort to investigate the association between serum OP levels, T2D risk, and fasting blood glucose (FBG) changes over a 5-year follow-up. Serum OP concentrations were measured by gas chromatography–triple quadrupole mass spectrometry. Among the 29 types of OPs detected, Chlorpyrifos and Fenitrothion had detection rates of 99.9% and 87.9%, respectively. Etrimfos and Parathion were detected in 75.8% and 64.5% of participants. Four types of OPs—Ethoprophos, Phorate, Diazinon, and Malathion, categorized into ≤LOD and >LOD groups—had detection rates ranging from 20% to 60%. OP exposure was not associated with T2D risk in the overall population. Among participants with baseline FBG ≥ 6.1 mmol/L, OP exposure showed a positive association with incident T2D and with increases in FBG during a 5-year follow-up. In contrast, OP exposure was associated with decreased FBG in the overall population. Moreover, significant interactions were observed between OP exposure and baseline FBG levels (Pinteraction < 0.05), suggesting that baseline glucose levels may modify the metabolic effects of chronic OP exposure. These findings highlight the importance of considering basal glucose status when evaluating the long-term metabolic effects of OP exposure. Full article
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