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UHPLC-MS/MS Methods for the Identification of Emerging Contaminant Transformation Products...
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Special Issue "UHPLC-MS/MS Methods for the Identification of Emerging Contaminant Transformation Products in Surface Water"

A special issue of Separations (ISSN 2297-8739).

Deadline for manuscript submissions: 15 November 2021.

Special Issue Editor

Dr. Fabio Gosetti
E-Mail Website
SciProfiles
Guest Editor
Department of Earth and Environmental Sciences, University of Milano-Bicocca, 20126 Milano, Italy
Interests: HPLC/MS; UHPLC/MS; mass spectrometry; unknown degradation products of pesticides; environmental pollutants; non-target analysis; method development and validation; food analysis

Special Issue Information

Dear Colleagues,

Large quantities of contaminants of emerging concerns (CECs) are released into water bodies every day. These micropollutants include not only natural and synthetic chemicals (pesticides, pharmaceuticals, personal care products, drugs of abuse, surfactants, food additives, and industrial chemicals) but also their transformation products that naturally form in the environment. In particular, sunlight photodegradation, hydrolysis reactions, or microbial degradation can occur together or individually to contribute to the formation of unknown CEC transformation products. Such chemicals are not included in routine monitoring programs and they are not regulated yet, although they have high potential to cause damage to the environment and suspected harmful effects on ecosystems and human health. For most of them, little information is available on their persistence and toxicity in the environment, indeed, in some cases, transformation products are also potentially more toxic than their precursors. Liquid chromatography coupled with mass spectrometry due to its sensitivity and selectivity is the choice technique for the identification and the determination of CECs at ultra-trace level in surface water.

This Special Issue will be comprised of research articles, short communications, and reviews related to the identification of CEC transformation products in surface water by UHPLC-MS/MS methods, giving a broad overview for their monitoring and future regulation.

Dr. Fabio Gosetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Transformation products
  • Emerging contaminants
  • Sunlight photodegradation
  • Environmental fate
  • Unknown degradation products
  • Surface water
  • Mass spectrometry
  • UHPLC-MS/MS

Published Papers (1 paper)

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Research

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Article
A Rapid Analytical Approach for Monitoring Pharmaceuticals in Hospital Wastewater—A DPX-Based Procedure with Environmentally-Friendly Extraction Phase Coupled to High Performance Liquid Chromatography–Diode Array/Fluorescence Detectors
by
Vanessa Meneghini
,
Gabriela Corazza
,
Hérica A. Magosso
,
Josias Merib
and
Eduardo Carasek
Separations 2021, 8(8), 109; https://doi.org/10.3390/separations8080109 - 29 Jul 2021
Viewed by 337
Abstract
In this study, a novel analytical methodology based on disposable pipette extraction (DPX) was developed using an alternative extraction phase for the extraction/determination of six pharmaceutical compounds, including carbamazepine, diclofenac, naproxen, fluoxetine, losartan and 17α-ethinylestradiol, in samples of hospital wastewater by high-performance liquid [...] Read more.
In this study, a novel analytical methodology based on disposable pipette extraction (DPX) was developed using an alternative extraction phase for the extraction/determination of six pharmaceutical compounds, including carbamazepine, diclofenac, naproxen, fluoxetine, losartan and 17α-ethinylestradiol, in samples of hospital wastewater by high-performance liquid chromatography coupled to diode array and fluorescence detectors. The performance of three extraction phases was examined, including 3-n-propyl (3-methylpyridinium) silsesquioxane chloride (Si3Py+Cl−), the conductive polymer polypyrrole (PPy), and polypyrrole modified with cetyltrimethylammonium bromide (PPy.CTAB). The optimization of the experimental parameters was performed through univariate and multivariate approaches. The optimized condition was obtained with the use of 20 mg of Si3Py+Cl− as extraction phase; six extraction cycles with 700 μL of sample in each cycle and 15 s of extraction time; three desorption cycles with 100 μL of ACN (same aliquot) and 15 s of desorption time; and sample pH adjusted at 3.5 and addition of 15% (w/v) of NaCl in the sample. The methodology proposed exhibited environmentally-friendly aspects with a significantly reduced volume of organic solvent (only 100 µL) and a small amount of extraction phase (20 mg). In addition, the extraction phase employed exhibits a simple synthetic procedure, low cost, and high stability in organic solvent. Moreover, the method developed exhibits high throughput (extraction time of 6.5 min per sample), and robustness. The analytical figures of merit were obtained using hospital wastewater, and the values were very satisfactory. The correlation coefficients were higher than 0.9710. LODs and LOQs ranged from 0.030 µg L−1 to 1.510 µg L−1 and 0.10 µg L−1 to 5.00 µg L−1, respectively. Relative recoveries varied from 80 to 127%, and intra-day (n = 3) and inter-day (n = 9) precision was lower than 19%. Full article
(This article belongs to the Special Issue UHPLC-MS/MS Methods for the Identification of Emerging Contaminant Transformation Products in Surface Water)
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