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Photoacoustic Sensing and Imaging in Biomedicine
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Photoacoustic Sensing and Imaging in Biomedicine

A special issue of Sensors (ISSN 1424-8220).

Deadline for manuscript submissions: closed (30 November 2018) | Viewed by 25483

Special Issue Editors

Dr. Wenfeng Xia

E-Mail Website
Guest Editor
Department of Medical Physics and Biomedical Engineering, University College London, London, UK
Interests: photoacoustic imaging; ultrasound sensing; medical device tracking and navigation; medical phantoms
Dr. Adrien Desjardins

E-Mail Website
Guest Editor
Department of Medical Physics and Biomedical Engineering, University College London, London, UK
Interests: photoacoustic imaging and sensing; ultrasound imaging and sensing; optical imaging and spectroscopy; optical coherence tomography; medical device development

Special Issue Information

Dear Colleagues,

Photoacoustics (PA), also known as optoacoustics, is one of the most exciting research areas in biomedicine. PA involves the generation of ultrasound waves by excitation light, via the photoacoustic effect. Signals from optically absorbing molecules can be obtained with spectroscopic specificity, and they can be spatially resolved using acoustic or optical focusing. As such, PA provides information that is complementary to conventional ultrasound sensing and imaging, and it holds great potential for pre-clinical and clinical biomedical applications. This Special Issue encompasses a broad range of PA techniques, including recent advances in instrumentation for both point sensing and imaging.

Topics include, but are not limited to:

  • Sources and delivery methods for excitation light
  • Ultrasound sensors
  • Signal processing algorithms
  • Image reconstruction algorithms
  • Laser-generated ultrasound
  • Tissue mimicking phantoms
  • Contrast agents
  • Photoacoustic spectroscopic measurements
  • Thermoacoustic sensing and imaging

Dr. Wenfeng Xia
Dr. Adrien Desjardins
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photoacoustic sensing
  • photoacoustic imaging
  • biomedicine

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Published Papers (3 papers)

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Research

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10 pages, 2320 KiB  
Article
Photoacoustic Signal Enhancement: Towards Utilization of Low Energy Laser Diodes in Real-Time Photoacoustic Imaging
by Rayyan Manwar, Matin Hosseinzadeh, Ali Hariri, Karl Kratkiewicz, Shahryar Noei and Mohammad R. N. Avanaki
Sensors 2018, 18(10), 3498; https://doi.org/10.3390/s18103498 - 17 Oct 2018
Cited by 66 | Viewed by 4635
Abstract
In practice, photoacoustic (PA) waves generated with cost-effective and low-energy laser diodes, are weak and almost buried in noise. Reconstruction of an artifact-free PA image from noisy measurements requires an effective denoising technique. Averaging is widely used to increase the signal-to-noise ratio (SNR) [...] Read more.
In practice, photoacoustic (PA) waves generated with cost-effective and low-energy laser diodes, are weak and almost buried in noise. Reconstruction of an artifact-free PA image from noisy measurements requires an effective denoising technique. Averaging is widely used to increase the signal-to-noise ratio (SNR) of PA signals; however, it is time consuming and in the case of very low SNR signals, hundreds to thousands of data acquisition epochs are needed. In this study, we explored the feasibility of using an adaptive and time-efficient filtering method to improve the SNR of PA signals. Our results show that the proposed method increases the SNR of PA signals more efficiently and with much fewer acquisitions, compared to common averaging techniques. Consequently, PA imaging is conducted considerably faster. Full article
(This article belongs to the Special Issue Photoacoustic Sensing and Imaging in Biomedicine)
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13 pages, 4213 KiB  
Article
Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures
by Wenfeng Xia, Mithun Kuniyil Ajith Singh, Efthymios Maneas, Naoto Sato, Yusuke Shigeta, Toshitaka Agano, Sebastian Ourselin, Simeon J. West and Adrien E. Desjardins
Sensors 2018, 18(5), 1394; https://doi.org/10.3390/s18051394 - 1 May 2018
Cited by 90 | Viewed by 10384
Abstract
Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of the invasive medical device and the procedure’s target is often challenging. Photoacoustic imaging has shown great promise for guiding minimally invasive procedures, but clinical translation of this technology has [...] Read more.
Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of the invasive medical device and the procedure’s target is often challenging. Photoacoustic imaging has shown great promise for guiding minimally invasive procedures, but clinical translation of this technology has often been limited by bulky and expensive excitation sources. In this work, we demonstrate the feasibility of guiding minimally invasive procedures using a dual-mode photoacoustic and ultrasound imaging system with excitation from compact arrays of light-emitting diodes (LEDs) at 850 nm. Three validation experiments were performed. First, clinical metal needles inserted into biological tissue were imaged. Second, the imaging depth of the system was characterized using a blood-vessel-mimicking phantom. Third, the superficial vasculature in human volunteers was imaged. It was found that photoacoustic imaging enabled needle visualization with signal-to-noise ratios that were 1.2 to 2.2 times higher than those obtained with ultrasound imaging, over insertion angles of 26 to 51 degrees. With the blood vessel mimicking phantom, the maximum imaging depth was 38 mm. The superficial vasculature of a human middle finger and a human wrist were clearly visualized in real-time. We conclude that the LED-based system is promising for guiding minimally invasive procedures with peripheral tissue targets. Full article
(This article belongs to the Special Issue Photoacoustic Sensing and Imaging in Biomedicine)
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Review

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24 pages, 8794 KiB  
Review
Review of Low-Cost Photoacoustic Sensing and Imaging Based on Laser Diode and Light-Emitting Diode
by Hongtao Zhong, Tingyang Duan, Hengrong Lan, Meng Zhou and Fei Gao
Sensors 2018, 18(7), 2264; https://doi.org/10.3390/s18072264 - 13 Jul 2018
Cited by 94 | Viewed by 9245
Abstract
Photoacoustic tomography (PAT), a promising medical imaging method that combines optical and ultrasound techniques, has been developing for decades mostly in preclinical application. A recent trend is to utilize the economical laser source to develop a low-cost sensing and imaging system, which aims [...] Read more.
Photoacoustic tomography (PAT), a promising medical imaging method that combines optical and ultrasound techniques, has been developing for decades mostly in preclinical application. A recent trend is to utilize the economical laser source to develop a low-cost sensing and imaging system, which aims at an affordable solution in clinical application. These low-cost laser sources have different modulation modes such as pulsed modulation, continuous modulation and coded modulation to generate different profiles of PA signals in photoacoustic (PA) imaging. In this paper, we review the recent development of the photoacoustic sensing and imaging based on the economical laser sources such as laser diode (LD) and light-emitting diode (LED) in different kinds of modulation types, and discuss several representative methods to improve the performance of such imaging systems based on low-cost laser sources. Finally, some perspectives regarding the future development of portable PAT systems are discussed, followed by the conclusion. Full article
(This article belongs to the Special Issue Photoacoustic Sensing and Imaging in Biomedicine)
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