Next Article in Journal
Assessment of Performance of the Industrial Process of Bulk Vacuum Packaging of Raw Meat with Nondestructive Optical Oxygen Sensing Systems
Next Article in Special Issue
Review of Low-Cost Photoacoustic Sensing and Imaging Based on Laser Diode and Light-Emitting Diode
Previous Article in Journal
Double-Group Particle Swarm Optimization and Its Application in Remote Sensing Image Segmentation
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Sensors 2018, 18(5), 1394; https://doi.org/10.3390/s18051394

Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures

1
Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, Charles Bell House, 67-73 Riding House Street, London W1W 7EJ, UK
2
Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London WC1E 6BT, UK
3
Research and Business Development Division, PreXion Corporation, Stationsplein 45 A4.004, 3013AK Rotterdam, The Netherlands
4
Research and Development Division, 1-14-1, Kandasudacho, Chiyoda-ku, Tokyo 101-0041, Japan
5
Centre for Medical Imaging Computing, University College London, Gower Street, London WC1E 6BT, UK
6
Department of Anaesthesia, University College Hospital, Main Theatres, Maple Bridge Link Corridor, Podium 3, 235 Euston Road, London NW1 2BU, UK
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 10 March 2018 / Revised: 25 April 2018 / Accepted: 27 April 2018 / Published: 1 May 2018
(This article belongs to the Special Issue Photoacoustic Sensing and Imaging in Biomedicine)
Full-Text   |   PDF [4213 KB, uploaded 2 May 2018]   |  

Abstract

Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of the invasive medical device and the procedure’s target is often challenging. Photoacoustic imaging has shown great promise for guiding minimally invasive procedures, but clinical translation of this technology has often been limited by bulky and expensive excitation sources. In this work, we demonstrate the feasibility of guiding minimally invasive procedures using a dual-mode photoacoustic and ultrasound imaging system with excitation from compact arrays of light-emitting diodes (LEDs) at 850 nm. Three validation experiments were performed. First, clinical metal needles inserted into biological tissue were imaged. Second, the imaging depth of the system was characterized using a blood-vessel-mimicking phantom. Third, the superficial vasculature in human volunteers was imaged. It was found that photoacoustic imaging enabled needle visualization with signal-to-noise ratios that were 1.2 to 2.2 times higher than those obtained with ultrasound imaging, over insertion angles of 26 to 51 degrees. With the blood vessel mimicking phantom, the maximum imaging depth was 38 mm. The superficial vasculature of a human middle finger and a human wrist were clearly visualized in real-time. We conclude that the LED-based system is promising for guiding minimally invasive procedures with peripheral tissue targets. View Full-Text
Keywords: photoacoustic imaging; ultrasonography; LED; needle guidance; vasculature; minimally invasive procedures photoacoustic imaging; ultrasonography; LED; needle guidance; vasculature; minimally invasive procedures
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Xia, W.; Kuniyil Ajith Singh, M.; Maneas, E.; Sato, N.; Shigeta, Y.; Agano, T.; Ourselin, S.; J. West, S.; E. Desjardins, A. Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures. Sensors 2018, 18, 1394.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top