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Special Issue "DNA-Based Sensors for Single-Molecule Biology II"

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (10 November 2022) | Viewed by 294

Special Issue Editor

Prof. Dr. Isaac Li
E-Mail Website
Guest Editor
Department of Chemistry, University of British Columbia, Kelowna, BC V1V 1V7, Canada
Interests: single-molecule force spectroscopy; single-molecule fluorescence; DNA-based biosensors and molecular devices; mechanobiology; molecular force sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Sensors will be dedicated to DNA-based molecular sensors for studying biological processes at the single-molecule level. Molecular biosensors have played a crucial role in understanding biological systems from the single-cell level to tissues and organisms. The detection of individual, single-molecule events in a single cell is necessary to gain insight into the cells’ heterogeneity, spatial distribution, noise, sensitivity, and regulation of molecular processes. Research into DNA-based molecular sensors has been exceptionally active, as a result of their “programmable” nature, in the creation of designer structural (e.g., DNA origami), function (e.g., DNAzymes), and detection/imaging (e.g., DNA-PAINT) elements.

In this Special Issue, we will feature the most recent progress in this field, from modeling and simulation studies to the development of new constructs of DNA-based sensors, as well as new experimental methods using these sensors for imaging and detection.

Potential topics include but are not limited to the following:

  •  Cellular processes sensing (e.g., metabolite, tension, signaling);
  •  DNA origami and supramolecular assembly;
  •  Single-molecule and super-resolution imaging;
  •  Single-molecule force spectroscopy;
  •  Imaging technique and method development;
  •  Modeling and simulation;
  • Theoretical sensing strategy.

Prof. Dr. Isaac Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA/RNA/nucleic acid
  • single-molecule
  • imaging
  • force spectroscopy
  • biosensor
  • super-resolution
  • molecular structures

Published Papers

There is no accepted submissions to this special issue at this moment.
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