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Microfluidics for Biosensing Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 2755

Special Issue Editors


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Guest Editor
Department of Engineering and System Science, Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan
Interests: MEMS/NEMS; microfluidics; 3D tissue culture; electrochemical sensors; nanotechnology in biomedical applications
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Guest Editor
National Tsing Hua University, Hsinchu, Taiwan
Interests: nano-biosensors; nanomedicines; nanomaterials; drug discovery; radiation thearpy

Special Issue Information

Dear Colleagues,

The first concept of micro total analysis system (MicroTAS) was proposed in 1990, and microfluidic chips have developed into various fields over the past 30 years. The reaction time and applied reagents of microfluidic systems are faster and fewer than those using conventional methods, representing a revolutionary advancement on bio-assay processes. Microfluidics combined with biosensing technologies is one of the most vibrant research areas in this field. Biosensing technologies, such as electrochemical, optical, mechanical, and electrical detections realized on different microfluidic devices with various substrates, including glass, silicon, polymer or paper, are utilized to detect/analyze various targets, including nucleotide (DNA, RNA), proteins, enzymes, cells, tissues, and organs. This Special Issue is aiming at those advanced technologies through the incorporation of microfluidic and biosensing systems for biological/environmental/clinical applications.

Prof. Fan-Gang Tseng
Dr. Wei-Cheng Wu
Guest Editors

Manuscript Submission Information

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Keywords

  • Microfluidic systems for biosensing
  • Nanofluidic biosensing systems
  • Assays in droplet microfluidics
  • Lab-on-a-chip systems
  • Microfluidics for pathogen detection
  • Paper-based later flow biosensor
  • Point-of-care microfluidic devices
  • Hematology microfluidic systems

Published Papers (1 paper)

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Research

15 pages, 23033 KiB  
Article
3D Microfluidic Devices in a Single Piece of Paper for the Simultaneous Determination of Nitrite and Thiocyanate
by Peng Yu, Muhan Deng, Yi Yang, Beixi Nie and Shaoyu Zhao
Sensors 2020, 20(15), 4118; https://doi.org/10.3390/s20154118 - 24 Jul 2020
Cited by 13 | Viewed by 2339
Abstract
The concentrations of nitrite and thiocyanate in saliva can be used as the biomarkers of the progression of periodontitis disease and environmental tobacco smoke exposure, respectively. Therefore, it is particularly necessary to detect these two indicators in saliva. Herein, the three-dimensional single-layered paper-based [...] Read more.
The concentrations of nitrite and thiocyanate in saliva can be used as the biomarkers of the progression of periodontitis disease and environmental tobacco smoke exposure, respectively. Therefore, it is particularly necessary to detect these two indicators in saliva. Herein, the three-dimensional single-layered paper-based microfluidic analytical devices (3D sl-μPADs) were, for the first time, fabricated by the spraying technique for the colorimetric detection of nitrite and thiocyanate at the same time. The conditions for 3D sl-μPADs fabrication were optimized in order to well control the penetration depth of the lacquer in a paper substrate. Then, the developed 3D sl-μPADs were utilized to simultaneously detect nitrite and thiocyanate and the limits of detection are 0.0096 and 0.074 mM, respectively. What is more, the μPADs exhibited good specificity, good repeatability, and acceptable recoveries in artificial saliva. Therefore, the developed 3D sl-μPADs show a great potential to determine nitrite and thiocyanate for the assessment of the human health. Full article
(This article belongs to the Special Issue Microfluidics for Biosensing Applications)
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