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Advances in Micro/Nanofabrication and Smart Biomaterials for HealthCare Systems

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Sensor Materials".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2738

Special Issue Editor


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Guest Editor
Department of Electrical and Computer Engineering, College of Engineering & Computing Sciences, New York Institute of Technology (NYIT), Northern Boulevard, Old Westbury, NY 11568, USA
Interests: biomedical devices; nanotechnology; disease diagnostics; biomaterials; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advancements in the fields of micro/nanotechnology with the evolution of smart biomaterials have revolutionized healthcare systems. Because most biological events originate at molecular or cellular levels, micro/nanofabrication can provide tools to investigate the presence of pathogens, enhance cell–surface interactions, stimulate gene expressions, and sense therapeutic measures on a very small scale. The integration of microfabrication and smart biomaterials can offer marvelous opportunities in order to solve significant problems in health sciences. Advances in technology and biomaterials at the micro and nano scale can have immediate and far-reaching impacts on healthcare systems and medicine, and can assist a wide spectrum of applications in sensing, diagnostics, therapeutics, and tissue engineering. 

This Special Issue aims to showcase advancements in nanoscience and biomaterials, drawing up contributions by researchers from medicine, engineering, chemistry, physics, biology, and materials science. We wish to cover research work that focuses on the development of novel biomaterials, nano-biosensors, wearable devices, micro-electronics, tissue engineering, therapeutics, drug delivery, and other technology modernizations in medicine and healthcare systems. 

Dr. Azhar Ilyas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • microfabrication
  • nanobiosensors
  • bioelectronics
  • wearable devices
  • tissue engineering

Published Papers (2 papers)

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Research

17 pages, 3074 KiB  
Article
Development of a Microfluidic Device for Exosome Isolation in Point-of-Care Settings
by Natasha Ramnauth, Elise Neubarth, Amy Makler-Disatham, Mazhar Sher, Steven Soini, Vivian Merk and Waseem Asghar
Sensors 2023, 23(19), 8292; https://doi.org/10.3390/s23198292 - 7 Oct 2023
Cited by 2 | Viewed by 1368
Abstract
Exosomes have gained recognition in cancer diagnostics and therapeutics. However, most exosome isolation methods are time-consuming, costly, and require bulky equipment, rendering them unsuitable for point-of-care (POC) settings. Microfluidics can be the key to solving these challenges. Here, we present a double filtration [...] Read more.
Exosomes have gained recognition in cancer diagnostics and therapeutics. However, most exosome isolation methods are time-consuming, costly, and require bulky equipment, rendering them unsuitable for point-of-care (POC) settings. Microfluidics can be the key to solving these challenges. Here, we present a double filtration microfluidic device that can rapidly isolate exosomes via size-exclusion principles in POC settings. The device can efficiently isolate exosomes from 50–100 µL of plasma within 50 min. The device was compared against an already established exosome isolation method, polyethylene glycol (PEG)-based precipitation. The findings showed that both methods yield comparable exosome sizes and purity; however, exosomes isolated from the device exhibited an earlier miRNA detection compared to exosomes obtained from the PEG-based isolation. A comparative analysis of exosomes collected from membrane filters with 15 nm and 30 nm pore sizes showed a similarity in exosome size and miRNA detection, with significantly increased sample purity. Finally, TEM images were taken to analyze how the developed devices and PEG-based isolation alter exosome morphology and to analyze exosome sizes. This developed microfluidic device is cost-efficient and time-efficient. Thus, it is ideal for use in low-resourced and POC settings to aid in cancer and disease diagnostics and therapeutics. Full article
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19 pages, 5403 KiB  
Article
Real-Time Nitrate Ion Monitoring with Poly(3,4-ethylenedioxythiophene) (PEDOT) Materials
by Michael C. Kohler, Fang Li, Ziqian Dong and Reza K. Amineh
Sensors 2023, 23(17), 7627; https://doi.org/10.3390/s23177627 - 3 Sep 2023
Cited by 1 | Viewed by 994
Abstract
Nitrate (NO3) pollution in groundwater, caused by various factors both natural and synthetic, contributes to the decline of human health and well-being. Current techniques used for nitrate detection include spectroscopic, electrochemical, chromatography, and capillary electrophoresis. It is highly desired to develop [...] Read more.
Nitrate (NO3) pollution in groundwater, caused by various factors both natural and synthetic, contributes to the decline of human health and well-being. Current techniques used for nitrate detection include spectroscopic, electrochemical, chromatography, and capillary electrophoresis. It is highly desired to develop a simple cost-effective alternative to these complex methods for nitrate detection. Therefore, a real-time poly (3,4-ethylenedioxythiophene) (PEDOT)-based sensor for nitrate ion detection via electrical property change is introduced in this study. Vapor phase polymerization (VPP) is used to create a polymer thin film. Variations in specific parameters during the process are tested and compared to develop new insights into PEDOT sensitivity towards nitrate ions. Through this study, the optimal fabrication parameters that produce a sensor with the highest sensitivity toward nitrate ions are determined. With the optimized parameters, the electrical resistance response of the sensor to 1000 ppm nitrate solution is 41.79%. Furthermore, the sensors can detect nitrate ranging from 1 ppm to 1000 ppm. The proposed sensor demonstrates excellent potential to detect the overabundance of nitrate ions in aqueous solutions in real time. Full article
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