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Innovative Fluorescent Probes and Their Role in Bioimaging

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (5 July 2024) | Viewed by 931

Special Issue Editors


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Guest Editor
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
Interests: fluorescence probe design; super resolution fluorescence imaging

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Guest Editor
Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan
Interests: fluorescence probes for quantitative imaging of intracellular redox-related biomolecules; spontaneously blinking fluorophores for super-resolution imaging

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Guest Editor
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China
Interests: functional organic dyes and bioimaging

Special Issue Information

Dear Colleagues,

In recent years, fluorescence imaging technology has undergone a remarkable transformation, with the introduction of cutting-edge techniques such as confocal, two-photon fluorescence, and super-resolution fluorescence imaging. These advancements have elevated fluorescence imaging to pivotal status in life science research, enabling real-time visualization and meticulous quantification of dynamic events within living cells at the molecular level. Fluorescence imaging technology relies on small molecule fluorescent probes due to their small size, ease of chemical modification, excellent reproducibility, and biocompatibility. Hence, fluorescent probes based on different fluorophores, such as rhodamine, fluorescein, BODIPY, anthocyanins, coumarin, and naphthylamide, have been developed and successfully applied in ion detection, enzyme analysis, and cell imaging. These continuous advancements not only facilitate the evolution of smart fluorescent probes but also inspire the development of inventive tools for scientific research and practical applications.

This Special Issue will therefore focus on original research and review articles covering recent advances in small organic fluorescent probes used in living cells and their bioimaging.

Dr. Qinglong Qiao
Prof. Dr. Mako Kamiya
Prof. Dr. Hua Zhang
Guest Editors

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Keywords

  • organic dyes
  • fluorescent probes
  • fluorescence imaging
  • super-resolution imaging
  • biosensors
  • bioimaging

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Published Papers (1 paper)

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Research

12 pages, 2766 KiB  
Article
FITA-Containing 2,4-Dinitrophenyl Alkylthioether-Based Probe for Detection and Imaging of GSH
by Yalun Dong, Liyue Wang, Wenfang Liang, Jiqin Zhu, Lu Sun and Long Yi
Sensors 2025, 25(1), 34; https://doi.org/10.3390/s25010034 - 24 Dec 2024
Viewed by 544
Abstract
Glutathione (GSH) plays a crucial role in various physiological processes and its imbalances are closely related to various pathological conditions. Probes for detection and imaging of GSH are not only useful for understanding GSH chemical biology but are also important for exploring potential [...] Read more.
Glutathione (GSH) plays a crucial role in various physiological processes and its imbalances are closely related to various pathological conditions. Probes for detection and imaging of GSH are not only useful for understanding GSH chemical biology but are also important for exploring potential theranostic agents. Herein, we report a fast intramolecular thiol-activated arylselenoamides (FITA)-based fluorescent probe using 2,4-dinitrophenyl alkylthioether as a sulfydryl-selective receptor for the first time. The fluorescence of the probe was low due to the double effects of PET, while the probe exhibits an 86-fold fluorescence enhancement at 460 nm after GSH activation and a detection limit of 0.95 μM. Furthermore, the probe is low-toxic and capable of imaging cellular GSH. This work further expands the design and applicability of the FITA-based platform, offering a new thiol-deprotection strategy for development of fluorescent probes. Full article
(This article belongs to the Special Issue Innovative Fluorescent Probes and Their Role in Bioimaging)
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