Development of Targeted Therapies for the Clinical Management of Cancer

A special issue of Sci (ISSN 2413-4155).

Deadline for manuscript submissions: closed (15 October 2020) | Viewed by 7051

Special Issue Editor


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Guest Editor
College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1005 Campus Delivery, Fort Collins, CO 80523, USA
Interests: targeted therapy; oncology; small molecular inhibitors; monoclonal antibodies; gene targeting; protein targeting
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Special Issue Information

Dear Colleagues,

The development of targeted therapeutics has revolutionized the approach to targeting cancer in a way that minimizes the adverse side-effects associated with broad-spectrum applications. For example, small molecule enzyme inhibitors and monoclonal antibodies can be designed to target the specific biomolecules involved in tumorigenic cascades. In this Special Issue of Sci, we invite papers related to the design, development, testing, and regulatory approval pathways associated with targeted oncology therapeutics. Potential topics include, but are not limited to, the following:

  • Identification of cancer-specific targets
  • Methods for oncology therapeutic design
  • Types of targeted therapeutics
  • Gene targets
  • Protein targets
  • Small molecule inhibitors
  • Monoclonal antibodies
  • Targeting tumor-specific proliferation
  • Targeting angiogenic pathways
  • Targeting tumorigenic signal transduction
  • Special regulatory pathways for approval of targeted therapeutics

Prof. Mark Brown
Guest Editor

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Keywords

  • Targeted therapy
  • Oncology
  • Small molecular inhibitors
  • Monoclonal antibodies
  • Gene targeting.

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Published Papers (1 paper)

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4 pages, 475 KiB  
Commentary
Advancing Therapies for Cancer—From Mustard Gas to CAR T
by Dillon K. Jarrell, Seth Drake and Mark A. Brown
Sci 2020, 2(4), 90; https://doi.org/10.3390/sci2040090 - 7 Dec 2020
Cited by 1 | Viewed by 4350
Abstract
The development of targeted therapeutics for cancer continues to receive intense research attention as laboratories and pharmaceutical companies seek to develop drugs and technologies that improve treatment efficacy and mitigate harmful side effects. In the aftermath of World War I, it was discovered [...] Read more.
The development of targeted therapeutics for cancer continues to receive intense research attention as laboratories and pharmaceutical companies seek to develop drugs and technologies that improve treatment efficacy and mitigate harmful side effects. In the aftermath of World War I, it was discovered that mustard gas destroys rapidly dividing cells and could be used to treat cancer. Since then, chemotherapy has remained a predominant treatment for cancer; however, the destruction of dividing cells throughout the body yields devastating side effects including off-target damage of the digestive tract, bone marrow, skin, and reproductive tract. Furthermore, the high mutation rate of cancerous cells often renders chemotherapy ineffective long-term. Therapies with improved specificity, localization, and efficacy are redefining cancer treatment. Herein, we define and summarize the principal advancements in targeted cancer treatment and briefly comment on the march towards personalized medicine in the treatment of human cancer. Full article
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