Cycloaddition Reactions at the Beginning of the Third Millennium, 2nd Edition
A special issue of Reactions (ISSN 2624-781X).
Deadline for manuscript submissions: 15 July 2026 | Viewed by 8058
Special Issue Editors
Interests: nitrogen heterocycles; pyridazines; nitroisoxazoles; pyridyl- and quinolyl-carbinols; metal-free reductions; hantzsch ester 1,4-dihydropyridine mimics; nitro compounds; indolizidine derivatives; biodiesel; biomass valorization
Special Issues, Collections and Topics in MDPI journals
Interests: catalysis; organocatalysis; heterocycles; synthetic methodologies; materials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Almost a century after the discovery of the Diels–Alder cycloaddition, this kind of pericyclic process continues to be a very efficient tool in synthetic organic chemistry and shows significant and widespread applications in different chemistry areas, from traditional organic synthesis to medicinal chemistry, materials chemistry, and so on. These reactions are beneficial to chemists because they provide valuable cyclic compounds, often in a simple manner and with high and predictable regio- and stereochemistry in addition to high atom economy. These appealing features make cycloadditions privileged processes in organic synthesis.
In this context, this Special Issue in Reactions aims to collect recent results concerning the applications of [4+2] cycloadditions, namely Diels–Alder, hetero Diels–Alder, and 1,3-dipolar cycloadditions, as well as [2+2] processes. The use of more efficient, green, and sustainable experimental conditions is strongly pursued to improve both the environmental aspects and the synthesis of carbo- and heterocycles with noteworthy applications in the natural, pharmacological, biological, and materials domains.
All researchers working in this field are invited to contribute to this issue emphasizing synthetic and methodological results, as well as mechanistic and/or theoretical aspects. Review articles by experts in the field are also welcome.
Prof. Donatella Giomi
Prof. Fabrizio Machetti
Guest Editors
Manuscript Submission Information
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Keywords
- Diels–Alder reactions
- hetero Diels–Alder reactions
- 1,3-dipolar cycloadditions
- [2+2]-cycloadditions
- selectivity
- photochemical reactions
- theoretical studies
- atom economy
- sustainable approaches
- heterocycle synthesis
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