Special Issue "Striated Muscle Proteomics"
A special issue of Proteomes (ISSN 2227-7382).
Deadline for manuscript submissions: closed (29 February 2016)
We warmly invite contributions of original research or review articles that enhance understanding regarding striated muscle biology. Striated muscle is a fascinating tissue that exhibits profound plasticity in response to mechanical loading, nutrition and exogenous agents. Skeletal muscle undergoes a complex developmental process that creates mature multinucleate fibres exhibiting a broad range of different phenotypes. In response to endurance exercise, muscle can more than double its mitochondrial content, whereas resistance exercise stimulates protein accretion and substantial myofibre hypertrophy. Interestingly, cardiac muscle is exposed to a continuous rhythmic workload yet pathological and physiological stimuli result in discrete forms of cardiac hypertrophy.
Muscle is the target of monogenic diseases, including muscular dystrophies and complex polygenic diseases such as type 2 diabetes. Similarly, cardiomyopathies occur due to inherited or environmental factors and are often progressive processes that coincide with other complicated risk factors such as low exercise capacity, hypertension and dyslipidaemia. Therefore, understanding the deterioration of cardiac performance is a particularly challenging area of research. Indeed, from adulthood to old-age the natural decline in muscle mass and cardiac function negatively impact individuals’ functional independence and health-span.
Striated muscle is a technically challenging substrate for proteomic investigation and so we also welcome methodological articles that aim to address muscle-specific issues. For example, approximately half of the protein content of skeletal muscle is accounted for by just 10 proteins, and the dynamic range of muscle protein abundance is second only to blood plasma. Therefore, deep mining of the muscle proteome is particularly challenging. Similarly, the broad diversity in muscle phenotype is underpinned by complex patterns of expression of protein isoforms and splice variants, many of which share high levels of sequence homology, which makes peptide-level studies challenging.
We hope this special issue will serve as a point of reference for burgeoning themes in striated muscle proteomics.
Dr. Jatin G Burniston Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Adaptation to exercise
- Anabolic agents
- Cancer cachexia
- Cardiac muscle
- Disuse atrophy
- Insulin resistance
- Muscle development
- Muscle mitochondria
- Muscle wasting
- Muscular dystrophy
- Myofibre phenotyping
- Physiological/ Pathological cardiac hypertrophy