Special Issue "Probing the Dynamic Properties of the Kinome"
A special issue of Proteomes (ISSN 2227-7382).
Deadline for manuscript submissions: closed (31 May 2015).
Interests: protein phosphorylation and protein kinase-mediated signaling pathways; application of proteomics; protein kinase inhibitors as therapeutics; regulation of metabolic enzymes by phosphorylation and interacting proteins
Special Issues and Collections in MDPI journals
The human kinome is a highly interconnected network of ~500 kinases that controls a myriad of cellular events through reversible phosphorylation. This network is regulated by multiple inputs including second messengers, activation loop phosphorylation, feedback and cross-talk phosphorylation events, transcriptional modulation, post-translational modifications, dimerization, targeted degradation and other mechanisms. Aberrant activation of kinases, by mutations or over-expression, and the importance of these events to cell growth regulation are well documented in cancer biology. Not surprisingly, a large number of kinase inhibitors are in clinical trials for treatment of a variety of cancers and other diseases. However, efforts to study the kinome through the study of isolated kinase pathways have resulted in limited knowledge regarding the function of the kinome as an entity. New technologies have emerged that allow better characterization of kinome behavior ‘en masse’. The application of these approaches has lead to the realization that the kinome is highly dynamic and is capable of responding or “reprogramming” to growth or inhibitory signals. Identifying these homeostatic mechanisms will be important to understanding the action of targeted kinase inhibitors, particularly those that fail in the clinic for unknown reasons. The objective of this special issue is to explore recent studies designed to study the kinome and to evaluate the insight gained from this research.
Prof. Dr. Lee M. Graves
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- inhibitors (allosteric, competitive etc.)
- mass spectrometry
- drug resistance
- post-translational modification