Proteomics-Based Development of Biomarkers in Global Chronic Disease

Dear Colleagues,

Early diagnosis of global organ disease involves genomic, lipidomic and proteomic biomarker tests that may diagnose early neuron dysfunction with the prevention of various organ diseases. Diet and nutrition are closely linked to accelerated aging and may allow biomarker tests to provide adequate information with relevance to the immune system dysfunction and the severity of chronic diseases. In spite of various biomarker tests and analyte measurements for chronic diseases such as obesity and diabetes abnormal nuclear–mitochondria interactions persist with inflammation involved in the induction of programmed cell death. For example, in the developing world, LPS and xenobiotic levels may be responsible for altered biological interactions and supersede diagnostic technologies for biomarker analysis. Diagnostic technologies for biomarker analysis have become important with projected costs for biomarker analysis expected to increase to billions of dollars in the next few years but altered biological and cell membrane interactions may not allow early diagnosis of immune system dysfunction related to early progression of global organ disease.

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• Global health
• Chronic disease
• NAFLD
• Technologies
• Lipidomics
• Diagnosis
• Proteomics
• Genomics
• Biomarker tests
• Diabetes