Appetite Regulation and Mitophagy with Links to Chronic Disease and Alzheimer’s Disease

Dear Colleagues,

Nutritional research has become important in appetite regulation with improvements in health relevant to healthy diets and the prevention of chronic disease and Alzheimer’s disease. Environmental factors such as stress, anxiety, and depression are important to consider with relevance to appetite dysregulation and the global increase in chronic diseases such as diabetes and neurodegenerative diseases. The origins of metabolic diseases may involve the dysregulation of hormones, nuclear receptors, and neuropeptides in the brain and peripheral tissues. Appetite disorders and brain metabolic diseases associated with obesity and diabetes require early intervention with diet, lifestyle, and drug therapy to prevent non-alcoholic fatty liver disease (NAFLD) and Alzheimer’s disease. The effects of overnutrition on appetite and core body temperature regulation induce autoimmune disease and mitophagy that are involved in programmed cell death in insulin resistance and Alzheimer’s disease. Nutritional research is now essential to promote mitochondrial biogenesis that is connected to appetite regulation in both chronic and neurodegenerative diseases. The links between appetite dysregulation, endocrinology, and metabolism implicate the peptide apelin and the nuclear receptor Sirtuin 1 (Sirt 1) to be defective and involved in NAFLD and Alzheimer’s disease. Appetite regulation is now critical to the prevention of brain disorder therapy that may involve the reversal of synaptic plasticity defects that link diabetes to neurodegenerative diseases.

Dr. Ian James Martins
Guest Editor

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