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Polymers
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Biomacromolecular Applications in Tissue Engineering and Drug Delivery
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Biomacromolecular Applications in Tissue Engineering and Drug Delivery

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 15899

Special Issue Editors

Dr. Farnaz Ghorbani

E-Mail Website
Guest Editor
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany
Interests: bioprinting; tissue engineering; bioinspired-polymers
Dr. Behafarid Ghalandari

E-Mail Website
Guest Editor
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
Interests: biomolecules interaction; drug delivery; protein interaction

Special Issue Information

Dear Colleagues,

The aim of this Special Issue of Biomedicine is to publish studies that focus on biomimetic compounds created through biomaterials tailoring to improve drug delivery systems and promote the treatment of damaged tissue. Biomacromolecules are promising candidates for this aim due to their unique features. Accordingly, this Special Issue will highlight biomacromolecules-based innovative structures for biomedical applications, mainly tissue engineering and drug delivery systems. As such, we encourage submissions addressing, but not limited to, the following: development of implantable and personalized scaffolds using biomacromolecules for tissue repair; development of biomacromolecules-based innovative structures for drug delivery; development of biomacromolecules-based innovative structures for theranostics applications.

We look forward to receiving your work. 

Dr. Farnaz Ghorbani
Dr. Behafarid Ghalandari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • biomacromolecules
  • scaffolds
  • tissue engineering
  • drug delivery
  • sustainable
  • biodegradation
  • cell interaction
  • protein interaction
  • protein corona
  • theranostics

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Published Papers (3 papers)

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Research

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14 pages, 2876 KiB  
Article
Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration
by Simonida Lj. Tomić, Jovana S. Vuković, Marija M. Babić Radić, Vuk. V. Filipović, Dubravka P. Živanović, Miloš M. Nikolić and Jasmina Nikodinovic-Runic
Polymers 2023, 15(3), 589; https://doi.org/10.3390/polym15030589 - 24 Jan 2023
Cited by 6 | Viewed by 2769
Abstract
Scaffolding biomaterials are gaining great importance due to their beneficial properties for medical purposes. Targeted biomaterial engineering strategies through the synergy of different material types can be applied to design hybrid scaffolding biomaterials with advantageous properties for biomedical applications. In our research, a [...] Read more.
Scaffolding biomaterials are gaining great importance due to their beneficial properties for medical purposes. Targeted biomaterial engineering strategies through the synergy of different material types can be applied to design hybrid scaffolding biomaterials with advantageous properties for biomedical applications. In our research, a novel combination of the bioactive agent Manuka honey (MHo) with 2-hydroxyethyl methacrylate/gelatin (HG) hydrogel scaffolds was created as an efficient bioactive platform for biomedical applications. The effects of Manuka honey content on structural characteristics, porosity, swelling performance, in vitro degradation, and in vitro biocompatibility (fibroblast and keratinocyte cell lines) of hybrid hydrogel scaffolds were studied using Fourier transform infrared spectroscopy, the gravimetric method, and in vitro MTT biocompatibility assays. The engineered hybrid hydrogel scaffolds show advantageous properties, including porosity in the range of 71.25% to 90.09%, specific pH- and temperature-dependent swelling performance, and convenient absorption capacity. In vitro degradation studies showed scaffold degradability ranging from 6.27% to 27.18% for four weeks. In vitro biocompatibility assays on healthy human fibroblast (MRC5 cells) and keratinocyte (HaCaT cells) cell lines by MTT tests showed that cell viability depends on the Manuka honey content loaded in the HG hydrogel scaffolds. A sample containing the highest Manuka honey content (30%) exhibited the best biocompatible properties. The obtained results reveal that the synergy of the bioactive agent, Manuka honey, with 2-hydroxyethyl methacrylate/gelatin as hybrid hydrogel scaffolds has potential for biomedical purposes. By tuning the Manuka honey content in HG hydrogel scaffolds advantageous properties of hybrid scaffolds can be achieved for biomedical applications. Full article
(This article belongs to the Special Issue Biomacromolecular Applications in Tissue Engineering and Drug Delivery)
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Review

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22 pages, 36512 KiB  
Review
Advances in Peptide-Based Hydrogel for Tissue Engineering
by Negar Bakhtiary, Behafarid Ghalandari, Farnaz Ghorbani, Swastina Nath Varma and Chaozong Liu
Polymers 2023, 15(5), 1068; https://doi.org/10.3390/polym15051068 - 21 Feb 2023
Cited by 17 | Viewed by 3943
Abstract
The development of peptide-based materials has emerged as one of the most challenging aspects of biomaterials in recent years. It has been widely acknowledged that peptide-based materials can be used in a broad range of biomedical applications, particularly in tissue engineering. Among them, [...] Read more.
The development of peptide-based materials has emerged as one of the most challenging aspects of biomaterials in recent years. It has been widely acknowledged that peptide-based materials can be used in a broad range of biomedical applications, particularly in tissue engineering. Among them, hydrogels have been attracting considerable interest in tissue engineering because they mimic tissue formation conditions by providing a three-dimensional environment and a high water content. It has been found that peptide-based hydrogels have received more attention due to mimicking proteins, particularly extracellular matrix proteins, as well as the wide variety of applications they are capable of serving. It is without a doubt that peptide-based hydrogels have become the leading biomaterials of today owing to their tunable mechanical stability, high water content, and high biocompatibility. Here, we discuss in detail various types of peptide-based materials, emphasizing peptide-based hydrogels, and then we examine in detail how hydrogels are formed, paying particular attention to the peptide structures that are incorporated into the final structure. Following that, we discuss the self-assembly and formation of hydrogels under various conditions, as well as the parameters to be considered as critical factors, which include pH, amino acid composi- tion within the sequence, and cross-linking techniques. Further, recent studies on the development of peptide-based hydrogels and their applications in tissue engineering are reviewed. Full article
(This article belongs to the Special Issue Biomacromolecular Applications in Tissue Engineering and Drug Delivery)
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39 pages, 6729 KiB  
Review
Protein-Based Hydrogels: Promising Materials for Tissue Engineering
by Niyousha Davari, Negar Bakhtiary, Mehran Khajehmohammadi, Soulmaz Sarkari, Hamidreza Tolabi, Farnaz Ghorbani and Behafarid Ghalandari
Polymers 2022, 14(5), 986; https://doi.org/10.3390/polym14050986 - 28 Feb 2022
Cited by 54 | Viewed by 8237
Abstract
The successful design of a hydrogel for tissue engineering requires a profound understanding of its constituents’ structural and molecular properties, as well as the proper selection of components. If the engineered processes are in line with the procedures that natural materials undergo to [...] Read more.
The successful design of a hydrogel for tissue engineering requires a profound understanding of its constituents’ structural and molecular properties, as well as the proper selection of components. If the engineered processes are in line with the procedures that natural materials undergo to achieve the best network structure necessary for the formation of the hydrogel with desired properties, the failure rate of tissue engineering projects will be significantly reduced. In this review, we examine the behavior of proteins as an essential and effective component of hydrogels, and describe the factors that can enhance the protein-based hydrogels’ structure. Furthermore, we outline the fabrication route of protein-based hydrogels from protein microstructure and the selection of appropriate materials according to recent research to growth factors, crucial members of the protein family, and their delivery approaches. Finally, the unmet needs and current challenges in developing the ideal biomaterials for protein-based hydrogels are discussed, and emerging strategies in this area are highlighted. Full article
(This article belongs to the Special Issue Biomacromolecular Applications in Tissue Engineering and Drug Delivery)
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