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Polymers
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Smart Polymer in Biomedical Application
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Smart Polymer in Biomedical Application

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 5842

Special Issue Editors

Dr. Yadong Wu

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
Interests: high performance composite materials; biomaterials; 3D-printed tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Fang Wang

E-Mail Website
Guest Editor
Laboratory for Space Environment and Physical Sciences, Harbin Institute of Technology, Harbin 150001, China
Interests: biomaterials; membrane; tissue engineering; aerogel; biodegradation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We have been asked by the Editor of Polymers (MDPI) to coordinate a Special Issue entitled “Smart Polymer in Biomedical Application”. It is my pleasure to invite you to submit a research article or review paper to this SI.

A smart polymer is a kind of polymer whose properties will change significantly due to the slight physical and chemical stimulation of the external environment. Biomedical based on smart polymers have significant applications, such as photosensitive material, thermal material, pH-responsive material, shape memory material, and so on.

For this Special Issue, we welcome the submission of manuscripts related to the preparation and bio-applications of biomedical, based on either natural or synthetic smart polymers, in the forms of aerogels/foams, hydrogels, films, fibers, particles, and 3D-printed structures. Manuscripts that review the most up-to-date progress in the fabrication and bio-applications of these materials are also encouraged.

Dr. Yadong Wu
Dr. Fang Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smart polymer
  • biomedical
  • biobased polymers
  • composite
  • medical applications
  • 3D print
  • hydrogel

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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20 pages, 5038 KiB  
Article
Preparation of 3D Printed Polylactic Acid/Bacterial Cellulose Composite Scaffold for Tissue Engineering Applications
by Yadong Wu, Yunfeng Wang, Fang Wang, Yudong Huang and Jinmei He
Polymers 2022, 14(21), 4756; https://doi.org/10.3390/polym14214756 - 6 Nov 2022
Cited by 9 | Viewed by 2711
Abstract
Bacterial cellulose (BC) has become a universal biomaterial owing to its intrinsic properties. BC fibers are composed of microfibers with a diameter of 3–4 nm into fiber bundles with a thickness of 40–60 nm, and interweave with each other to form a well-developed [...] Read more.
Bacterial cellulose (BC) has become a universal biomaterial owing to its intrinsic properties. BC fibers are composed of microfibers with a diameter of 3–4 nm into fiber bundles with a thickness of 40–60 nm, and interweave with each other to form a well-developed ultra-fine network structure. Polylactic acid (PLA) has good mechanical properties and excellent biocompatibility and biodegradability. Therefore, PLA has been widely applied in tissue engineering. Addressed herein is a novel type of PLA/BC (PLA/BC) composite scaffold prepared by 3D printing (3D), 3D modeling of the required porous membrane material support established in the computer, and decomposition of the model into 5 layer 20 μM sheets. The range of PLA loadings assessed in this work was 1.0 wt.%, 1.5 wt.%, and 2.0 wt.%, and its physicochemical properties and biological properties were characterized and evaluated. Tensile strength of PLA/BC composite scaffolds increased to 66.49 MPa compared to that of a pure BC film (25.61 MPa). Hydrophilicity was tunable with the amount of added PLA. In this paper, the effects of 3D round hole and stripe surface topology on cell growth behavior were characterized. Schwann cells (SCs) adhered to the surface of the 3D composite membrane successfully, and their proliferation rate on the surface of the regular circular pore and stripe structure was better than that of the smooth surface. Erythrocyte fixation and platelet adhesion experiments showed that the 3D composite scaffold had excellent blood compatibility. Further degradation studies showed that loose structures appeared after 1 week, and structural defects began after 3 weeks. The in vitro degradation results showed that the degradation rate of the BC membrane in simulated body fluid after 6 weeks was 14.38%, while the degradation rate of the PLA/BC composite scaffold was 18.75%. Full article
(This article belongs to the Special Issue Smart Polymer in Biomedical Application)
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Review

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17 pages, 1035 KiB  
Review
Advances in Material Modification with Smart Functional Polymers for Combating Biofilms in Biomedical Applications
by Luis Alberto Mejía-Manzano, Patricia Vázquez-Villegas, Luis Vicente Prado-Cervantes, Kristeel Ximena Franco-Gómez, Susana Carbajal-Ocaña, Daniela Lizeth Sotelo-Cortés, Valeria Atehortúa-Benítez, Miguel Delgado-Rodríguez and Jorge Membrillo-Hernández
Polymers 2023, 15(14), 3021; https://doi.org/10.3390/polym15143021 - 12 Jul 2023
Cited by 5 | Viewed by 2430
Abstract
Biofilms as living microorganism communities are found anywhere, and for the healthcare sector, these constitute a threat and allied mechanism for health-associated or nosocomial infections. This review states the basis of biofilms and their formation. It focuses on their relevance for the biomedical [...] Read more.
Biofilms as living microorganism communities are found anywhere, and for the healthcare sector, these constitute a threat and allied mechanism for health-associated or nosocomial infections. This review states the basis of biofilms and their formation. It focuses on their relevance for the biomedical sector, generalities, and the major advances in modified or new synthesized materials to prevent or control biofilm formation in biomedicine. Biofilm is conceptualized as an aggregate of cells highly communicated in an extracellular matrix, which the formation obeys to molecular and genetic basis. The biofilm offers protection to microorganisms from unfavorable environmental conditions. The most frequent genera of microorganisms forming biofilms and reported in infections are Staphylococcus spp., Escherichia spp., and Candida spp. in implants, heart valves, catheters, medical devices, and prostheses. During the last decade, biofilms have been most commonly related to health-associated infections and deaths in Europe, the United States, and Mexico. Smart, functional polymers are materials capable of responding to diverse stimuli. These represent a strategy to fight against biofilms through the modification or synthesis of new materials. Polypropylene and poly-N-isopropyl acrylamide were used enough in the literature analysis performed. Even smart polymers serve as delivery systems for other substances, such as antibiotics, for biofilm control. Full article
(This article belongs to the Special Issue Smart Polymer in Biomedical Application)
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