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Bioactive and Biomedical Hydrogel Dressings for Wound Healing

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (30 December 2024) | Viewed by 5067

Special Issue Editors


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Guest Editor
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China
Interests: biomedical materials; hydrogels; tissue engineering; polymers
College of Life Sciences, Xinyang Normal University, Xinyang 464000, China
Interests: biopolymers; hydrogels; biomass; nanoparticles; bioprinting; drug delivery; tissue engineering
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Special Issue Information

Dear Colleagues,

Wound healing is a multi-stage process of repairing damaged tissue and restoring its integrity, and the process mainly involves hemostasis, inflammation, proliferation, and remodeling. Bioactive and biomedical hydrogel dressings have emerged as the most promising candidates in wound healing applications because of their favorable mechanical properties, biocompatibility, bioactive properties, and biodegradability features. Several preparation techniques have been characterized to generate bioactive and biomedical hydrogels, and a rational design in the fabrication of bioactive and biomedical hydrogel dressings guarantees successful applications, including skin tissue engineering and drug delivery.

This collection of works on bioactive and biomedical hydrogel dressings in wound healing showcases high-quality fundamental and basic research that covers a wide range of chemical, physical, and biological aspects surrounding the design of bioactive and biomedical hydrogel dressings for wound healing applications. The goal of this Special Issue is to publish research articles, short communications, review articles, and opinions.

Areas covered by this collection include, but are not limited to, the following:

  • The design of bioactive and biomedical hydrogel dressings;
  • Fabrication methods of bioactive and biomedical hydrogel dressings;
  • Molecules and signal release in bioactive and biomedical hydrogel dressings;
  • Stimuli-responsive bioactive and biomedical hydrogel dressings;
  • Performance and characteristics of bioactive and biomedical hydrogel dressings;
  • Bioactive and biomedical hydrogel dressings for scarless wound healing;
  • Bioactive and biomedical hydrogel dressings for chronic wound healing;
  • Bioactive and biomedical hydrogel dressings with monitoring functions. 

Dr. Yingying Chu
Dr. Lei Nie
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive hydrogels
  • dressings
  • wound healing
  • scarless wound
  • chronic wound
  • biomedical hydrogels

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Published Papers (2 papers)

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Research

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17 pages, 4833 KiB  
Article
Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan
by Ling Wang, Xiaoyue Ding, Xiaorui He, Ning Tian, Peng Ding, Wei Guo, Oseweuba Valentine Okoro, Yanfang Sun, Guohua Jiang, Zhenzhong Liu, Armin Shavandi and Lei Nie
Polymers 2024, 16(20), 2876; https://doi.org/10.3390/polym16202876 - 11 Oct 2024
Cited by 2 | Viewed by 1712
Abstract
Multifunctional hydrogel dressings remain highly sought after for the promotion of skin wound regeneration. In the present study, multifunctional CHS-DA/HACC (CH) hydrogels with an interpenetrated network were constructed using hydroxypropyl trimethyl ammonium chloride modified chitosan (HACC) and dopamine-modified chondroitin sulfate (CHS-DA), using genipin [...] Read more.
Multifunctional hydrogel dressings remain highly sought after for the promotion of skin wound regeneration. In the present study, multifunctional CHS-DA/HACC (CH) hydrogels with an interpenetrated network were constructed using hydroxypropyl trimethyl ammonium chloride modified chitosan (HACC) and dopamine-modified chondroitin sulfate (CHS-DA), using genipin as crosslinker. The synthesis of HACC and CHS-DA was effectively confirmed using Fourier transform infrared (FT-IR) analysis and 1H nuclear magnetic resonance (1H NMR) spectroscopy. The prepared CH hydrogels exhibited a network of interconnected pores within the microstructure. Furthermore, rheological testing demonstrated that CH hydrogels exhibited strong mechanical properties, stability, and injectability. Further characterization investigations showed that the CH hydrogels showed favorable self-healing and self-adhesion properties. It was also shown that increasing HACC concentration ratio was positively correlated with the antibacterial activity of CH hydrogels, as evidenced by their resistance to Escherichia coli and Staphylococcus aureus. Additionally, Cell Counting Kit-8 (CCK-8) tests, fluorescent images, and a cell scratch assay demonstrated that CH hydrogels had good biocompatibility and cell migration ability. The multifunctional interpenetrated network hydrogels were shown to have good antibacterial properties, antioxidant properties, stable storage modulus and loss modulus, injectable properties, self-healing properties, and biocompatibility, highlighting their potential as wound dressings in wound healing applications. Full article
(This article belongs to the Special Issue Bioactive and Biomedical Hydrogel Dressings for Wound Healing)
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Review

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23 pages, 6798 KiB  
Review
Advanced Hybrid Strategies of GelMA Composite Hydrogels in Bone Defect Repair
by Han Yu, Xi Luo, Yanling Li, Lei Shao, Fang Yang, Qian Pang, Yabin Zhu and Ruixia Hou
Polymers 2024, 16(21), 3039; https://doi.org/10.3390/polym16213039 - 29 Oct 2024
Cited by 1 | Viewed by 2991
Abstract
To date, severe bone defects remain a significant challenge to the quality of life. All clinically used bone grafts have their limitations. Bone tissue engineering offers the promise of novel bone graft substitutes. Various biomaterial scaffolds are fabricated by mimicking the natural bone [...] Read more.
To date, severe bone defects remain a significant challenge to the quality of life. All clinically used bone grafts have their limitations. Bone tissue engineering offers the promise of novel bone graft substitutes. Various biomaterial scaffolds are fabricated by mimicking the natural bone structure, mechanical properties, and biological properties. Among them, gelatin methacryloyl (GelMA), as a modified natural biomaterial, possesses a controllable chemical network, high cellular stability and viability, good biocompatibility and degradability, and holds the prospect of a wide range of applications. However, because they are hindered by their mechanical properties, degradation rate, and lack of osteogenic activity, GelMA hydrogels need to be combined with other materials to improve the properties of the composites and endow them with the ability for osteogenesis, vascularization, and neurogenesis. In this paper, we systematically review and summarize the research progress of GelMA composite hydrogel scaffolds in the field of bone defect repair, and discuss ways to improve the properties, which will provide ideas for the design and application of bionic bone substitutes. Full article
(This article belongs to the Special Issue Bioactive and Biomedical Hydrogel Dressings for Wound Healing)
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