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Polymers
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Molecularly Imprinted Polymers: Design, Characterization and Application, 2nd Edition
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Molecularly Imprinted Polymers: Design, Characterization and Application, 2nd Edition

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: closed (25 April 2025) | Viewed by 3003

Special Issue Editors

Dr. Vilma Ratautaite

E-Mail Website
Guest Editor
Center for Physical Sciences and Technology (FTMC), Vilnius, Lithuania
Interests: molecularly imprinted polymers; conducting polymers; electrochemical sensors; electrochemical deposition
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Arunas Ramanavicius

E-Mail Website
Guest Editor
NanoTechnas—Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania
Interests: electrochemistry; bioelectrochemistry; molecularly imprinted polymers; conducting polymers; electrochemical sensors; electrochemical deposition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to submit research articles and reviews to a Special Issue of Polymers. For this Special Issue, we aim to present the most recent developments in the design, characterization, and application of molecularly imprinted polymers (MIPs). The different methods of MIP production, the characterization of dominant features of their surfaces, and the characterization of interactions between the polymer and the target molecule are within the scope of this Special Issue. Additionally, various types of additives (gold, silver, or platinum nanoparticles; multiwalled carbon nanotubes; MXenes; quantum dots; etc.) are used in the design of MIPs. Therefore, characterizing the impact of these additives on the interaction of the MIP with the target molecule is encouraged. Subsequently, extracting the imprinted molecule from the polymer after polymerization is critical to the final performance of an MIP. Finally, various applications of MIPs in electrochemical sensors, wearable sensors, and many other fields also are within the scope of this Special Issue.

Dr. Vilma Ratautaite
Prof. Dr. Arunas Ramanavicius
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecularly imprinted polymers (MIPs)
  • molecular imprinting technology
  • conducting polymers
  • conjugated polymer
  • electrochemical deposition
  • electrochemical sensors
  • synthetic receptors

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Published Papers (1 paper)

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Research

16 pages, 3025 KiB  
Article
Electrochemical Biosensors by Means of Molecularly Imprinted Polymers (MIPs) Cortisol Recognition
by Jindapa Nampeng, Naphatsawan Vongmanee, Chuchart Pintavirooj, Wen-Tai Chiu and Sarinporn Visitsattapongse
Polymers 2025, 17(4), 545; https://doi.org/10.3390/polym17040545 - 19 Feb 2025
Viewed by 2380
Abstract
Depression and anxiety are two common mental health issues that require serious attention, as they have significant impacts on human well-being, with both being emotionally and physically reflected in the increasing number of suicide cases globally. The World Health Organization (WHO) estimated that [...] Read more.
Depression and anxiety are two common mental health issues that require serious attention, as they have significant impacts on human well-being, with both being emotionally and physically reflected in the increasing number of suicide cases globally. The World Health Organization (WHO) estimated that about 322 million people around the world experienced mental illnesses in 2017, and this number continues to increase. Cortisol is a major stress-controlled hormone that is regulated by the hypothalamic–pituitary–adrenal (HPA) axis. The HPA axis has three main components, including the hypothalamus, pituitary gland, and adrenal gland, where cortisol, the primary stress hormone, is released. It plays crucial roles in responding to stress, energy balance, and the immune system. The cortisol level in the bloodstream usually increases when stress develops. Molecularly imprinted polymers (MIPs) have been highlighted in terms of creating artificial bioreceptors by mimicking the shape of detected biomolecules, making natural bioreceptor molecules no longer required. MIPs can overcome the limitations of chemicals and physical properties reducing over time and the short-time shelf life of natural bioreceptors. MIPs’ benefits are reflected in their ease of use, high sensitivity, high specificity, reusability, durability, and the lack of requirement for complicated sample preparation before use. Moreover, MIPs incur low costs in manufacturing, giving them a favorable budget for the market with simple utilization. MIPs can be formulated by only three key steps, including formation, the polymerization of functional monomers, and the creation of three-dimensional cavities mimicking the shape and size of targeting molecules. MIPs have a high potential as biosensors, especially working as bioanalytics for protein, anti-body, antigen, or bacteria detection. Herein, this research proposes an MIP-based cortisol biosensor in which cortisol is imprinted on methyl methacrylate (MMA) and methacrylic acid (MAA) produced by UV polymerization. This MIP-based biosensor may be an alternative method with which to detect and monitor the levels of hormones in biological samples such as serum, saliva, or urine due to its rapid detection ability, which would be of benefit for diagnosing depression and anxiety and prescribing treatment. In this study, quantitative detection was performed using an electrochemical technique to measure the changes in electrical signals in different concentrations of a cortisol solution ranging from 0.1 to 1000 pg/mL. The MIP-based biosensor, as derived by calculation, achieved its best detection limit of 1.035 pg/mL with a gold electrode. Tests were also performed on molecules with a similar molecular structure, including Medroxyprogesterone acetate and drospirenone, to ensure the sensitivity and accuracy of the sensors, demonstrating a low sensitivity and low linear response. Full article
(This article belongs to the Special Issue Molecularly Imprinted Polymers: Design, Characterization and Application, 2nd Edition)
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