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Polymers for Aesthetic Purposes

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 2415

Special Issue Editor


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Guest Editor
College of Dentistry, Yonsei University, Seoul 03722, Republic of Korea
Interests: rehabilitation medicine; aesthetics medicine; plastic reconstructive surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled "Polymers for Aesthetic Purposes", aims to focus on the latest advancements and applications of polymers, such as polydioxanone (PDO), poly-L-lactic acid (PLAs), polynucleotides, hyaluronic acid, and polycaprolactone (PCL) in aesthetic medicine. These biodegradable polymers have revolutionized the field by offering minimally invasive solutions for skin rejuvenation, wrinkle reduction, tissue regeneration, and overall facial and body contouring. This Special Issue aims to explore the multifaceted roles of these polymers, their biocompatibility, and their mechanisms of action, along with the latest clinical findings and innovative techniques. Topics are welcome to focus on, but are not limited to, polymer-based fillers, threads, regenerative therapies, and combination treatments. This Special Issue also aims to delve into emerging trends, safety profiles, patient outcomes, and future directions in the use of these polymers for aesthetic enhancement. By bringing together research articles and reviews, this Special Issue seeks to provide a comprehensive platform for sharing knowledge and advancing the field of aesthetic medicine through the innovative use of polymers.

Dr. Kyu-ho Yi
Guest Editor

Manuscript Submission Information

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Keywords

  • polydioxanone (PDO)
  • poly-L-lactic acid (PLAs)
  • polynucleotides
  • hyaluronic acid
  • polycaprolactone (PCL)
  • skin rejuvenation
  • wrinkle reduction
  • tissue regeneration
  • facial and body contouring

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Published Papers (1 paper)

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Research

21 pages, 2999 KiB  
Article
In Vitro Evaluation and Clinical Effects of a Regenerative Complex with Non-Cross-Linked Hyaluronic Acid and a High-Molecular-Weight Polynucleotide for Periorbital Treatment
by Hanadi Sami Abuyousif, Alexandre Porcello, Marco Cerrano, Cíntia Marques, Corinne Scaletta, Kelly Lourenço, Philippe Abdel-Sayed, Michèle Chemali, Wassim Raffoul, Nathalie Hirt-Burri, Lee Ann Applegate and Alexis E. Laurent
Polymers 2025, 17(5), 638; https://doi.org/10.3390/polym17050638 - 27 Feb 2025
Viewed by 2123
Abstract
Skin aging is a complex and multifactorial process influenced by both intrinsic and extrinsic factors. The periorbital area of the face is particularly susceptible to premature aging signs due to its delicate skin structure, and is a major concern for many individuals. While [...] Read more.
Skin aging is a complex and multifactorial process influenced by both intrinsic and extrinsic factors. The periorbital area of the face is particularly susceptible to premature aging signs due to its delicate skin structure, and is a major concern for many individuals. While hyaluronic acid (HA)-based dermal filler products are commonly used for periorbital rejuvenation, novel approaches to effectively locally address the visible signs of aging are available. This study aimed to investigate Innovyal Regenerative Action (IRA), an injectable polynucleotide–HA (PN-HA) regenerative complex designed for periocular prejuvenation. Firstly, PN-HA was compared to other commercially available HA-based dermbooster products (Profhilo®, Suisselle Cellbooster® Glow, and NCTF® 135 HA) in terms of rheological properties, in vitro antioxidant capacity, and total collagen production stimulation in human fibroblasts. Secondly, the clinical effects of the IRA PN-HA complex were evaluated in two case reports (monotherapy for periorbital prejuvenation). It was shown that the PN-HA complex outperformed its comparators in terms of relative rheological behavior (biophysical attributes normalized to polymer contents), intrinsic antioxidant activity (CUPRAC, FRAP, and ORAC assays), as well as total collagen level induction (72-h in vitro dermal fibroblast induction model). Generally, the results of this study provided mechanistic and preliminary clinical insights into the potential benefits of the IRA PN-HA complex for periocular cutaneous treatment. Overall, it was underscored that combining the structural support and regenerative properties of PN with the hydrating and volumizing effects of HA bares tangible potential for multifactorial skin quality enhancement and for periocular prejuvenation in particular. Full article
(This article belongs to the Special Issue Polymers for Aesthetic Purposes)
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