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Advanced Biodegradable Polymers for Drug Delivery: 2nd Edition

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 674

Special Issue Editor


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Guest Editor
Division of Industrial Pharmacy, Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland
Interests: natural polymers; polymeric materials; microparticles; controlled release; encapsulation techniques; jonotropic gelation; hydrogels; solid–solid systems
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Special Issue Information

Dear Colleagues,

Biodegradable polymers have important properties which make them very useful for the preparation of different drug delivery systems. The wide range forms of drugs, as well as their possibility to coat or enclose active substance inside polymers, make them powerful pharmaceutical tools. The encapsulation of active substances in polymeric particles, as well as the preparation of hydrogels or eye preparations, make them important excipients. Also, the modification of structure or complex (mixed) preparations plays a new role and brings novel solutions in drug delivery systems.

This Special Issue aims to publish articles concerned with the use of new compositions of biodegradable polymers in the field of pharmaceutical drug development and their current or potential applications. Authors are invited to submit both original research and reviews.

Dr. Barbara Jadach
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biopolymer
  • biodegradability
  • drug delivery
  • biomedical application
  • controlled release
  • functional polymers
  • smart polymers

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Published Papers (2 papers)

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Research

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20 pages, 2127 KB  
Article
Amorphous Lycopene–PVP K30 Dispersions Prepared by Ball Milling: Improved Solubility and Antioxidant Activity
by Anna Kulawik, Maciej Kulawik, Natalia Rosiak, Wei Lu, Judyta Cielecka-Piontek and Przemysław Zalewski
Polymers 2025, 17(21), 2916; https://doi.org/10.3390/polym17212916 - 31 Oct 2025
Cited by 1 | Viewed by 533
Abstract
Lycopene is a carotenoid with strong antioxidant properties, but its therapeutic potential is limited by its poor aqueous solubility. Developing formulations that enhance its solubility and stability may improve its bioavailability and effectiveness. This study aimed to prepare amorphous lycopene–PVP K30 systems via [...] Read more.
Lycopene is a carotenoid with strong antioxidant properties, but its therapeutic potential is limited by its poor aqueous solubility. Developing formulations that enhance its solubility and stability may improve its bioavailability and effectiveness. This study aimed to prepare amorphous lycopene–PVP K30 systems via ball milling, a solvent-free and mild technique, and to evaluate their physicochemical properties, solubility, and antioxidant activity. Formulations containing 5%, 10%, and 15% lycopene (w/w) were obtained and characterized using X-ray powder diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy. Density Functional Theory calculations were performed to gain molecular-level insights into lycopene–polymer interactions and hydrogen-bond formation. Solubility was determined by high-performance liquid chromatography, and antioxidant activity was evaluated using the DPPH radical scavenging assay. The amorphous dispersions exhibited enhanced solubility compared to crystalline lycopene, with the 10% system showing the highest initial solubility and antioxidant capacity, while the 5% formulation demonstrated superior stability over 24 h. Ball milling proved to be an efficient method for producing amorphous lycopene–PVP K30 dispersions with improved dissolution and bioactive performance. The results indicate that lycopene loadings between 5 and 10% offer the most favorable balance between solubility, stability, and antioxidant activity, supporting their potential use in pharmaceutical formulations. Full article
(This article belongs to the Special Issue Advanced Biodegradable Polymers for Drug Delivery: 2nd Edition)
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Review

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48 pages, 3055 KB  
Review
Recent Advances in Pharmaceutical and Medical Applications in the Area of Selected Porphyrinoids Connected with PLGA or PLGA-Based Modalities
by Patrycja Koza, Jakub Kubiak, Tomasz Goslinski and Tomasz Koczorowski
Polymers 2025, 17(23), 3190; https://doi.org/10.3390/polym17233190 - 29 Nov 2025
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Abstract
The challenges associated with solubility and bioavailability of porphyrinoid-type photosensitizers in photodynamic therapy require solutions that are based on modern drug carriers, including polymeric nanoparticles. With that in mind this review discusses poly(lactic-co-glycolic acid, PLGA)-based polymeric nanoparticles encapsulating selected well-known photosensitizers, [...] Read more.
The challenges associated with solubility and bioavailability of porphyrinoid-type photosensitizers in photodynamic therapy require solutions that are based on modern drug carriers, including polymeric nanoparticles. With that in mind this review discusses poly(lactic-co-glycolic acid, PLGA)-based polymeric nanoparticles encapsulating selected well-known photosensitizers, such as protoporphyrin IX, tetrahydroxyphenylporphyrin, chlorin e6, and tetracarboxyphenylporphyrin, with a view to the physicochemical and biological properties. Also discussed are their potential medical applications towards photodynamic and sonodynamic therapy. PLGA-based nanoparticles, encapsulating photosensitizers, were analysed in terms of particle size, surface charge, morphology, loading efficiency, release kinetics, and stability. Moreover, the cellular uptake and subcellular localisation of carriers were considered in correlation to polymer composition and surface functionalisation. Special attention was given to how PEGylation, lipid-hybrid coatings, or the incorporation of additional therapeutic or imaging agents has modulated both the physicochemical properties and biological activities of photosensitizers. The comparative assessment of different porphyrinoid-based photosensitizers highlighted how hydrophobicity, amphiphilicity, and molecular structure have an influence on encapsulation efficiency and therapeutic outcomes. Furthermore, issues such as the premature release of photosensitizers, along with limited bioavailability, and limited penetration through biological barriers were addressed as well as some proposed mitigation strategies. Overall, this review highlights the versatility of PLGA nanoparticles as a powerful platform for photosensitizer delivery, with promising implications for advancing polymer-based nanomedicine and improving the efficacy of photodynamic therapy. Full article
(This article belongs to the Special Issue Advanced Biodegradable Polymers for Drug Delivery: 2nd Edition)
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